| 1 | Fri 4 Aug | 172-1 v Sheffield WednesdaySheffield Wednesday 1-2 Southampton |
| 2 | Sat 12 Aug | 174-4 v Norwich CitySouthampton 4-4 Norwich City |
| 3 | Sat 19 Aug | 17 2-1 v Plymouth ArgylePlymouth Argyle 1-2 Southampton |
| 4 | Sat 26 Aug | 17 2-1 v Queens Park RangersSouthampton 2-1 Queens Park Rangers |
| 5 | Sat 2 Sep | 170-5 v SunderlandSunderland 5-0 Southampton |
| 6 | Fri 15 Sep | 171-4 v Leicester CitySouthampton 1-4 Leicester City |
| 7 | Tue 19 Sep | 170-1 v Ipswich TownSouthampton 0-1 Ipswich Town |
| 8 | Sat 23 Sep | 171-2 v MiddlesbroughMiddlesbrough 2-1 Southampton |
| 9 | Sat 30 Sep | 173-1 v Leeds UnitedSouthampton 3-1 Leeds United |
| 10 | Tue 3 Oct | 171-0 v Stoke CityStoke City 0-1 Southampton |
| 11 | Sat 7 Oct | 171-1 v Rotherham UnitedSouthampton 1-1 Rotherham United |
| 12 | Sat 21 Oct | 172-1 v Hull CityHull City 1-2 Southampton |
| 13 | Wed 25 Oct | 172-2 v Preston North EndPreston North End 2-2 Southampton |
| 14 | Sat 28 Oct | 173-1 v Birmingham CitySouthampton 3-1 Birmingham City |
| 15 | Sat 4 Nov | 171-0 v MillwallMillwall 0-1 Southampton |
| 16 | Sat 11 Nov | 172-1 v West Bromwich AlbionSouthampton 2-1 West Bromwich Albion |
| 17 | Sat 25 Nov | 171-1 v Huddersfield TownHuddersfield Town 1-1 Southampton |
| 18 | Wed 29 Nov | 171-0 v Bristol CitySouthampton 1-0 Bristol City |
| 19 | Sat 2 Dec | 172-0 v Cardiff CitySouthampton 2-0 Cardiff City |
| 20 | Sat 9 Dec | 17 1-1 v WatfordWatford 1-1 Southampton |
| 21 | Wed 13 Dec | 171-1 v Coventry CityCoventry City 1-1 Southampton |
| 22 | Sat 16 Dec | 174-0 v Blackburn RoversSouthampton 4-0 Blackburn Rovers |
| 23 | Sat 23 Dec | 171-0 v Queens Park RangersQueens Park Rangers 0-1 Southampton |
| 24 | Tue 26 Dec | 175-0 v Swansea CitySouthampton 5-0 Swansea City |
| 25 | Fri 29 Dec | 172-1 v Plymouth ArgyleSouthampton 2-1 Plymouth Argyle |
| 26 | Mon 1 Jan | 171-1 v Norwich CityNorwich City 1-1 Southampton |
| 27 | Sat 13 Jan | 174-0 v Sheffield WednesdaySouthampton 4-0 Sheffield Wednesday |
| 28 | Sat 20 Jan | 173-1 v Swansea CitySwansea City 1-3 Southampton |
| 29 | Sat 3 Feb | 17 2-0 v Rotherham UnitedRotherham United 0-2 Southampton |
| 30 | Sat 10 Feb | 175-3 v Huddersfield TownSouthampton 5-3 Huddersfield Town |
| 31 | Tue 13 Feb | 171-3 v Bristol CityBristol City 3-1 Southampton |
| 32 | Fri 16 Feb | 172-0 v West Bromwich AlbionWest Bromwich Albion 0-2 Southampton |
| 33 | Tue 20 Feb | 171-2 v Hull CitySouthampton 1-2 Hull City |
| 34 | Sat 24 Feb | 171-2 v MillwallSouthampton 1-2 Millwall |
| 35 | Sat 2 Mar | 174-3 v Birmingham CityBirmingham City 3-4 Southampton |
| 36 | Sat 9 Mar | 174-2 v SunderlandSouthampton 4-2 Sunderland |
| 37 | Fri 29 Mar | 17 1-1 v MiddlesbroughSouthampton 1-1 Middlesbrough |
| 38 | Mon 1 Apr | 172-3 v Ipswich TownIpswich Town 3-2 Southampton |
| 39 | Tue 9 Apr | 172-1 v Coventry CitySouthampton 2-1 Coventry City |
| 40 | Sat 13 Apr | 173-2 v WatfordSouthampton 3-2 Watford |
| 41 | Tue 16 Apr | 173-0 v Preston North EndSouthampton 3-0 Preston North End |
| 42 | Sat 20 Apr | 17 1-2 v Cardiff CityCardiff City 2-1 Southampton |
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