| 1 | Sat 19 Sep 2020 | 3 3-2 v 1. FC Köln1. FC Köln 2-3 1899 Hoffenheim | German Bundesliga |
| 2 | Sun 27 Sep 2020 | 34-1 v Bayern Munich1899 Hoffenheim 4-1 Bayern Munich | German Bundesliga |
| 3 | Sat 3 Oct 2020 | 31-2 v Eintracht FrankfurtEintracht Frankfurt 2-1 1899 Hoffenheim | German Bundesliga |
| 4 | Sun 24 Jan 2021 | 33-0 v 1. FC Köln1899 Hoffenheim 3-0 1. FC Köln | German Bundesliga |
| 5 | Sat 30 Jan 2021 | 31-4 v Bayern MunichBayern Munich 4-1 1899 Hoffenheim | German Bundesliga |
| 6 | Sun 7 Feb 2021 | 31-3 v Eintracht Frankfurt1899 Hoffenheim 1-3 Eintracht Frankfurt | German Bundesliga |
| 7 | Sat 13 Feb 2021 | 32-2 v Borussia DortmundBorussia Dortmund 2-2 1899 Hoffenheim | German Bundesliga |
| 8 | Thu 18 Feb 2021 | 33-3 v MoldeMolde 3-3 1899 Hoffenheim | Europa League Round of 32 |
| 9 | Sun 21 Feb 2021 | 3 4-0 v Werder Bremen1899 Hoffenheim 4-0 Werder Bremen | German Bundesliga |
| 10 | Thu 25 Feb 2021 | 30-2 v Molde1899 Hoffenheim 0-2 Molde | Europa League Round of 32 |
| 11 | Sun 28 Feb 2021 | 31-1 v 1. FC Union Berlin1. FC Union Berlin 1-1 1899 Hoffenheim | German Bundesliga |
| 12 | Sat 6 Mar 2021 | 32-1 v VfL Wolfsburg1899 Hoffenheim 2-1 VfL Wolfsburg | German Bundesliga |
| 13 | Sun 14 Mar 2021 | 30-2 v VfB StuttgartVfB Stuttgart 2-0 1899 Hoffenheim | German Bundesliga |
| 14 | Sun 21 Mar 2021 | 31-2 v Mainz 051899 Hoffenheim 1-2 Mainz 05 | German Bundesliga |
| 15 | Sat 3 Apr 2021 | 31-2 v FC AugsburgFC Augsburg 2-1 1899 Hoffenheim | German Bundesliga |
| 16 | Mon 12 Apr 2021 | 30-0 v Bayer 04 Leverkusen1899 Hoffenheim 0-0 Bayer 04 Leverkusen | German Bundesliga |
| 17 | Fri 16 Apr 2021 | 30-0 v RB LeipzigRB Leipzig 0-0 1899 Hoffenheim | German Bundesliga |
| 18 | Wed 21 Apr 2021 | 3 3-2 v Borussia Mönchengladbach1899 Hoffenheim 3-2 Borussia Mönchengladbach | German Bundesliga |
| 19 | Sat 24 Apr 2021 | 31-1 v SC FreiburgSC Freiburg 1-1 1899 Hoffenheim | German Bundesliga |
| 20 | Sat 8 May 2021 | 34-2 v FC Schalke 041899 Hoffenheim 4-2 FC Schalke 04 | German Bundesliga |
| 21 | Sat 15 May 2021 | 31-1 v Arminia BielefeldArminia Bielefeld 1-1 1899 Hoffenheim | German Bundesliga |
| 22 | Sat 22 May 2021 | 32-1 v Hertha Berlin1899 Hoffenheim 2-1 Hertha Berlin | German Bundesliga |
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