| 1 | Sun 27 Sep 2020 | 384-1 v Bayern Munich1899 Hoffenheim 4-1 Bayern Munich | German Bundesliga |
| 2 | Sat 3 Oct 2020 | 38 1-2 v Eintracht FrankfurtEintracht Frankfurt 2-1 1899 Hoffenheim | German Bundesliga |
| 3 | Sat 17 Oct 2020 | 38 0-1 v Borussia Dortmund1899 Hoffenheim 0-1 Borussia Dortmund | German Bundesliga |
| 4 | Thu 22 Oct 2020 | 382-0 v Red Star Belgrade1899 Hoffenheim 2-0 Red Star Belgrade | Europa League Group L |
| 5 | Sun 25 Oct 2020 | 38 1-1 v Werder BremenWerder Bremen 1-1 1899 Hoffenheim | German Bundesliga |
| 6 | Thu 29 Oct 2020 | 384-1 v KAA GentKAA Gent 1-4 1899 Hoffenheim | Europa League Group L |
| 7 | Mon 2 Nov 2020 | 381-3 v 1. FC Union Berlin1899 Hoffenheim 1-3 1. FC Union Berlin | German Bundesliga |
| 8 | Sat 21 Nov 2020 | 38 3-3 v VfB Stuttgart1899 Hoffenheim 3-3 VfB Stuttgart | German Bundesliga |
| 9 | Sun 29 Nov 2020 | 381-1 v Mainz 05Mainz 05 1-1 1899 Hoffenheim | German Bundesliga |
| 10 | Mon 7 Dec 2020 | 383-1 v FC Augsburg1899 Hoffenheim 3-1 FC Augsburg | German Bundesliga |
| 11 | Thu 10 Dec 2020 | 384-1 v KAA Gent1899 Hoffenheim 4-1 KAA Gent | Europa League Group L |
| 12 | Sun 13 Dec 2020 | 38 1-4 v Bayer 04 LeverkusenBayer 04 Leverkusen 4-1 1899 Hoffenheim | German Bundesliga |
| 13 | Sat 19 Dec 2020 | 38 2-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-2 1899 Hoffenheim | German Bundesliga |
| 14 | Sat 9 Jan 2021 | 380-4 v FC Schalke 04FC Schalke 04 4-0 1899 Hoffenheim | German Bundesliga |
| 15 | Sat 16 Jan 2021 | 380-0 v Arminia Bielefeld1899 Hoffenheim 0-0 Arminia Bielefeld | German Bundesliga |
| 16 | Tue 19 Jan 2021 | 383-0 v Hertha BerlinHertha Berlin 0-3 1899 Hoffenheim | German Bundesliga |
| 17 | Sun 24 Jan 2021 | 38 3-0 v 1. FC Köln1899 Hoffenheim 3-0 1. FC Köln | German Bundesliga |
| 18 | Sat 30 Jan 2021 | 381-4 v Bayern MunichBayern Munich 4-1 1899 Hoffenheim | German Bundesliga |
| 19 | Sun 7 Feb 2021 | 381-3 v Eintracht Frankfurt1899 Hoffenheim 1-3 Eintracht Frankfurt | German Bundesliga |
| 20 | Sat 13 Feb 2021 | 38 2-2 v Borussia DortmundBorussia Dortmund 2-2 1899 Hoffenheim | German Bundesliga |
| 21 | Sun 21 Mar 2021 | 381-2 v Mainz 051899 Hoffenheim 1-2 Mainz 05 | German Bundesliga |
| 22 | Sat 3 Apr 2021 | 381-2 v FC AugsburgFC Augsburg 2-1 1899 Hoffenheim | German Bundesliga |
| 23 | Mon 12 Apr 2021 | 380-0 v Bayer 04 Leverkusen1899 Hoffenheim 0-0 Bayer 04 Leverkusen | German Bundesliga |
| 24 | Fri 16 Apr 2021 | 38 0-0 v RB LeipzigRB Leipzig 0-0 1899 Hoffenheim | German Bundesliga |
| 25 | Wed 21 Apr 2021 | 38 3-2 v Borussia Mönchengladbach1899 Hoffenheim 3-2 Borussia Mönchengladbach | German Bundesliga |
| 26 | Sat 24 Apr 2021 | 381-1 v SC FreiburgSC Freiburg 1-1 1899 Hoffenheim | German Bundesliga |
| 27 | Sat 8 May 2021 | 384-2 v FC Schalke 041899 Hoffenheim 4-2 FC Schalke 04 | German Bundesliga |
| 28 | Sat 15 May 2021 | 381-1 v Arminia BielefeldArminia Bielefeld 1-1 1899 Hoffenheim | German Bundesliga |
| 29 | Sat 22 May 2021 | 382-1 v Hertha Berlin1899 Hoffenheim 2-1 Hertha Berlin | German Bundesliga |
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