| 1 | 8/8/2021 | 132-0 v StrasbourgStrasbourg 0-2 Angers | French Ligue 1 |
| 2 | 15/8/2021 | 133-0 v LyonAngers 3-0 Lyon | French Ligue 1 |
| 3 | 22/8/2021 | 131-1 v BordeauxBordeaux 1-1 Angers | French Ligue 1 |
| 4 | 29/8/2021 | 132-0 v RennesAngers 2-0 Rennes | French Ligue 1 |
| 5 | 12/9/2021 | 131-1 v BrestBrest 1-1 Angers | French Ligue 1 |
| 6 | 19/9/2021 | 71-4 v NantesAngers 1-4 Nantes | French Ligue 1 |
| 7 | 3/10/2021 | 73-2 v MetzAngers 3-2 Metz | French Ligue 1 |
| 8 | 15/10/2021 | 71-2 v Paris St GermainParis St Germain 2-1 Angers | French Ligue 1 |
| 9 | 22/10/2021 | 7 2-2 v Saint ÉtienneSaint Étienne 2-2 Angers | French Ligue 1 |
| 10 | 31/10/2021 | 71-2 v NiceAngers 1-2 Nice | French Ligue 1 |
| 11 | 6/11/2021 | 71-1 v LilleLille 1-1 Angers | French Ligue 1 |
| 12 | 21/11/2021 | 71-0 v LorientAngers 1-0 Lorient | French Ligue 1 |
| 13 | 26/11/2021 | 72-2 v LensLens 2-2 Angers | French Ligue 1 |
| 14 | 1/12/2021 | 71-3 v MonacoAngers 1-3 Monaco | French Ligue 1 |
| 15 | 5/12/2021 | 7 2-1 v ReimsReims 1-2 Angers | French Ligue 1 |
| 16 | 12/12/2021 | 70-1 v ClermontAngers 0-1 Clermont | French Ligue 1 |
| 17 | 22/12/2021 | 7 1-4 v MontpellierMontpellier 4-1 Angers | French Ligue 1 |
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