| 1 | Thu 23 Mar | 6 2-1 v ItalyItaly 1-2 England | European Championship Qualification Group C |
| 2 | Sun 26 Mar | 62-0 v UkraineEngland 2-0 Ukraine | European Championship Qualification Group C |
| 3 | Fri 16 Jun | 64-0 v MaltaMalta 0-4 England | European Championship Qualification Group C |
| 4 | Mon 19 Jun | 67-0 v North MacedoniaEngland 7-0 North Macedonia | European Championship Qualification Group C |
| 5 | Sun 3 Sep | 51-3 v ArsenalArsenal 3-1 Manchester United | Premier League |
| 6 | Sat 9 Sep | 6 1-1 v UkraineUkraine 1-1 England | European Championship Qualification Group C |
| 7 | Tue 12 Sep | 153-1 v ScotlandScotland 1-3 England | International Friendly |
| 8 | Tue 26 Sep | 53-0 v Crystal PalaceManchester United 3-0 Crystal Palace | Carabao Cup Third Round |
| 9 | Sat 30 Sep | 50-1 v Crystal PalaceManchester United 0-1 Crystal Palace | Premier League |
| 10 | Sat 7 Oct | 52-1 v BrentfordManchester United 2-1 Brentford | Premier League |
| 11 | Tue 17 Oct | 63-1 v ItalyEngland 3-1 Italy | European Championship Qualification Group C |
| 12 | Sat 21 Oct | 52-1 v Sheffield UnitedSheffield United 1-2 Manchester United | Premier League |
| 13 | Tue 24 Oct | 51-0 v FC CopenhagenManchester United 1-0 FC Copenhagen | UEFA Champions League Group A |
| 14 | Sun 29 Oct | 50-3 v Manchester CityManchester United 0-3 Manchester City | Premier League |
| 15 | Wed 1 Nov | 50-3 v Newcastle UnitedManchester United 0-3 Newcastle United | Carabao Cup Fourth Round |
| 16 | Sat 4 Nov | 51-0 v FulhamFulham 0-1 Manchester United | Premier League |
| 17 | Wed 8 Nov | 5 3-4 v FC CopenhagenFC Copenhagen 4-3 Manchester United | UEFA Champions League Group A |
| 18 | Sat 11 Nov | 51-0 v Luton TownManchester United 1-0 Luton Town | Premier League |
| 19 | Fri 17 Nov | 62-0 v MaltaEngland 2-0 Malta | European Championship Qualification Group C |
| 20 | Mon 20 Nov | 61-1 v North MacedoniaNorth Macedonia 1-1 England | European Championship Qualification Group C |
| 21 | Sun 26 Nov | 53-0 v EvertonEverton 0-3 Manchester United | Premier League |
| 22 | Wed 29 Nov | 53-3 v GalatasarayGalatasaray 3-3 Manchester United | UEFA Champions League Group A |
| 23 | Sat 2 Dec | 5 0-1 v Newcastle UnitedNewcastle United 1-0 Manchester United | Premier League |
| 24 | Wed 6 Dec | 52-1 v ChelseaManchester United 2-1 Chelsea | Premier League |
| 25 | Sat 9 Dec | 50-3 v AFC BournemouthManchester United 0-3 AFC Bournemouth | Premier League |
| 26 | Tue 12 Dec | 50-1 v Bayern MunichManchester United 0-1 Bayern Munich | UEFA Champions League Group A |
| 27 | Sun 28 Jan | 54-2 v Newport CountyNewport County 2-4 Manchester United | Emirates FA Cup Fourth Round |
| 28 | Thu 1 Feb | 54-3 v Wolverhampton WanderersWolverhampton Wanderers 3-4 Manchester United | Premier League |
| 29 | Sun 4 Feb | 53-0 v West Ham UnitedManchester United 3-0 West Ham United | Premier League |
| 30 | Sun 11 Feb | 52-1 v Aston VillaAston Villa 1-2 Manchester United | Premier League |
| 31 | Sun 18 Feb | 5 2-1 v Luton TownLuton Town 1-2 Manchester United | Premier League |
| 32 | Sat 24 Feb | 5 1-2 v FulhamManchester United 1-2 Fulham | Premier League |
| 33 | Sun 17 Mar | 54-3 v LiverpoolManchester United 4-3 Liverpool | Emirates FA Cup Quarter Final |
| 34 | Sat 23 Mar | 60-1 v BrazilEngland 0-1 Brazil | International Friendly |
| 35 | Sat 30 Mar | 51-1 v BrentfordBrentford 1-1 Manchester United | Premier League |
| 36 | Thu 4 Apr | 53-4 v ChelseaChelsea 4-3 Manchester United | Premier League |
| 37 | Sun 7 Apr | 52-2 v LiverpoolManchester United 2-2 Liverpool | Premier League |
| 38 | Sat 13 Apr | 52-2 v AFC BournemouthAFC Bournemouth 2-2 Manchester United | Premier League |
| 39 | Sun 21 Apr | 53-3 v Coventry CityCoventry City 3-3 Manchester United | Emirates FA Cup Semi Final |
| 40 | Wed 24 Apr | 54-2 v Sheffield UnitedManchester United 4-2 Sheffield United | Premier League |
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