| 1 | 11/8/2018 | 10-1 v Carshalton AthleticLewes 0-1 Carshalton Athletic | Bostik League Premier Division |
| 2 | 14/8/2018 | 10-0 v Tonbridge AngelsTonbridge Angels 0-0 Lewes | Bostik League Premier Division |
| 3 | 18/8/2018 | 12-1 v Dorking WanderersDorking Wanderers 1-2 Lewes | Bostik League Premier Division |
| 4 | 25/8/2018 | 10-0 v MoleseyMolesey 0-0 Lewes | Emirates FA Cup Preliminary Round |
| 5 | 27/8/2018 | 13-3 v Bognor Regis TownLewes 3-3 Bognor Regis Town | Bostik League Premier Division |
| 6 | 1/9/2018 | 11-0 v MargateMargate 0-1 Lewes | Bostik League Premier Division |
| 7 | 5/9/2018 | 18-1 v MoleseyLewes 8-1 Molesey | Emirates FA Cup Preliminary Round |
| 8 | 8/9/2018 | 12-2 v FarnboroughFarnborough 2-2 Lewes | Emirates FA Cup First Qualifying Round |
| 9 | 12/9/2018 | 11-1 v FarnboroughLewes 1-1 Farnborough | Emirates FA Cup First Qualifying Round |
| 10 | 15/9/2018 | 12-2 v Enfield TownLewes 2-2 Enfield Town | Bostik League Premier Division |
| 11 | 22/9/2018 | 11-1 v Kings LangleyKings Langley 1-1 Lewes | Emirates FA Cup Second Qualifying Round |
| 12 | 26/9/2018 | 12-1 v Kings LangleyLewes 2-1 Kings Langley | Emirates FA Cup Second Qualifying Round |
| 13 | 29/9/2018 | 11-0 v Wingate & FinchleyWingate & Finchley 0-1 Lewes | Bostik League Premier Division |
| 14 | 3/10/2018 | 13-4 v WorthingLewes 3-4 Worthing | Bostik League Premier Division |
| 15 | 6/10/2018 | 10-3 v Bath CityBath City 3-0 Lewes | Emirates FA Cup Third Qualifying Round |
| 16 | 13/10/2018 | 10-1 v Potters Bar TownPotters Bar Town 1-0 Lewes | Bostik League Premier Division |
| 17 | 16/10/2018 | 15-1 v AFC HornchurchAFC Hornchurch 1-5 Lewes | Bostik League Premier Division |
| 18 | 20/10/2018 | 12-0 v Folkestone InvictaLewes 2-0 Folkestone Invicta | Bostik League Premier Division |
| 19 | 23/10/2018 | 11-0 v WhitehawkWhitehawk 0-1 Lewes | Bostik League Premier Division |
| 20 | 27/10/2018 | 12-1 v Ashford Town (Middx)Ashford Town (Middx) 1-2 Lewes | Buildbase FA Trophy First Qualifying Round |
| 21 | 31/10/2018 | 12-1 v Harlow TownLewes 2-1 Harlow Town | Bostik League Premier Division |
| 22 | 3/11/2018 | 11-2 v KingstonianKingstonian 2-1 Lewes | Bostik League Premier Division |
| 23 | 10/11/2018 | 12-0 v Merthyr TownLewes 2-0 Merthyr Town | Buildbase FA Trophy Second Qualifying Round |
| 24 | 17/11/2018 | 10-1 v Haringey BoroughLewes 0-1 Haringey Borough | Bostik League Premier Division |
| 25 | 24/11/2018 | 12-2 v Hemel Hempstead TownLewes 2-2 Hemel Hempstead Town | Buildbase FA Trophy Third Qualifying Round |
| 26 | 27/11/2018 | 12-3 v Hemel Hempstead TownHemel Hempstead Town 3-2 Lewes | Buildbase FA Trophy Third Qualifying Round |
| 27 | 1/12/2018 | 11-0 v LeatherheadLewes 1-0 Leatherhead | Bostik League Premier Division |
| 28 | 5/12/2018 | 13-0 v Corinthian-CasualsLewes 3-0 Corinthian-Casuals | Bostik League Premier Division |
| 29 | 8/12/2018 | 12-1 v Bishop's StortfordBishop's Stortford 1-2 Lewes | Bostik League Premier Division |
| 30 | 12/12/2018 | 15-0 v Brightlingsea RegentLewes 5-0 Brightlingsea Regent | Bostik League Premier Division |
| 31 | 19/12/2018 | 12-3 v MersthamMerstham 3-2 Lewes | Bostik League Premier Division |
| 32 | 26/12/2018 | 12-2 v Bognor Regis TownBognor Regis Town 2-2 Lewes | Bostik League Premier Division |
| 33 | 1/1/2019 | 10-3 v Burgess Hill TownLewes 0-3 Burgess Hill Town | Bostik League Premier Division |
| 34 | 5/1/2019 | 11-1 v Enfield TownEnfield Town 1-1 Lewes | Bostik League Premier Division |
| 35 | 12/1/2019 | 14-3 v WorthingWorthing 3-4 Lewes | Bostik League Premier Division |
| 36 | 19/1/2019 | 14-2 v Wingate & FinchleyLewes 4-2 Wingate & Finchley | Bostik League Premier Division |
| 37 | 23/1/2019 | 10-0 v MargateLewes 0-0 Margate | Bostik League Premier Division |
| 38 | 26/1/2019 | 11-2 v Harlow TownHarlow Town 2-1 Lewes | Bostik League Premier Division |
| 39 | 2/2/2019 | 10-0 v Potters Bar TownLewes 0-0 Potters Bar Town | Bostik League Premier Division |
| 40 | 16/2/2019 | 10-2 v Dorking WanderersLewes 0-2 Dorking Wanderers | Bostik League Premier Division |
| 41 | 23/2/2019 | 11-2 v Carshalton AthleticCarshalton Athletic 2-1 Lewes | Bostik League Premier Division |
| 42 | 27/2/2019 | 10-0 v Tonbridge AngelsLewes 0-0 Tonbridge Angels | Bostik League Premier Division |
| 43 | 2/3/2019 | 11-3 v WhitehawkLewes 1-3 Whitehawk | Bostik League Premier Division |
| 44 | 5/3/2019 | 12-0 v Corinthian-CasualsCorinthian-Casuals 0-2 Lewes | Bostik League Premier Division |
| 45 | 9/3/2019 | 10-4 v Folkestone InvictaFolkestone Invicta 4-0 Lewes | Bostik League Premier Division |
| 46 | 16/3/2019 | 10-0 v Brightlingsea RegentBrightlingsea Regent 0-0 Lewes | Bostik League Premier Division |
| 47 | 23/3/2019 | 13-0 v KingstonianLewes 3-0 Kingstonian | Bostik League Premier Division |
| 48 | 30/3/2019 | 11-2 v Haringey BoroughHaringey Borough 2-1 Lewes | Bostik League Premier Division |
| 49 | 6/4/2019 | 12-1 v MersthamLewes 2-1 Merstham | Bostik League Premier Division |
| 50 | 13/4/2019 | 11-1 v LeatherheadLeatherhead 1-1 Lewes | Bostik League Premier Division |
| 51 | 20/4/2019 | 11-3 v Bishop's StortfordLewes 1-3 Bishop's Stortford | Bostik League Premier Division |