| 1 | Fri 24 Mar | 53-1 v PolandCzech Republic 3-1 Poland | European Championship Qualification Group E |
| 2 | Mon 27 Mar | 5 0-0 v MoldovaMoldova 0-0 Czech Republic | European Championship Qualification Group E |
| 3 | Sat 17 Jun | 53-0 v Faroe IslandsFaroe Islands 0-3 Czech Republic | European Championship Qualification Group E |
| 4 | Sat 12 Aug | 51-1 v AFC BournemouthAFC Bournemouth 1-1 West Ham United | Premier League |
| 5 | Sun 20 Aug | 53-1 v ChelseaWest Ham United 3-1 Chelsea | Premier League |
| 6 | Sat 26 Aug | 53-1 v Brighton & Hove AlbionBrighton & Hove Albion 1-3 West Ham United | Premier League |
| 7 | Fri 1 Sep | 52-1 v Luton TownLuton Town 1-2 West Ham United | Premier League |
| 8 | Thu 7 Sep | 51-1 v AlbaniaCzech Republic 1-1 Albania | European Championship Qualification Group E |
| 9 | Sat 16 Sep | 51-3 v Manchester CityWest Ham United 1-3 Manchester City | Premier League |
| 10 | Sun 24 Sep | 51-3 v LiverpoolLiverpool 3-1 West Ham United | Premier League |
| 11 | Sat 30 Sep | 52-0 v Sheffield UnitedWest Ham United 2-0 Sheffield United | Premier League |
| 12 | Thu 5 Oct | 52-1 v SC FreiburgSC Freiburg 1-2 West Ham United | UEFA Europa League Group A |
| 13 | Sun 8 Oct | 52-2 v Newcastle UnitedWest Ham United 2-2 Newcastle United | Premier League |
| 14 | Thu 12 Oct | 5 0-3 v AlbaniaAlbania 3-0 Czech Republic | European Championship Qualification Group E |
| 15 | Sun 22 Oct | 51-4 v Aston VillaAston Villa 4-1 West Ham United | Premier League |
| 16 | Sun 29 Oct | 50-1 v EvertonWest Ham United 0-1 Everton | Premier League |
| 17 | Wed 1 Nov | 53-1 v ArsenalWest Ham United 3-1 Arsenal | Carabao Cup Fourth Round |
| 18 | Sat 4 Nov | 52-3 v BrentfordBrentford 3-2 West Ham United | Premier League |
| 19 | Thu 9 Nov | 51-0 v OlympiakosWest Ham United 1-0 Olympiakos | UEFA Europa League Group A |
| 20 | Sun 12 Nov | 5 3-2 v Nottingham ForestWest Ham United 3-2 Nottingham Forest | Premier League |
| 21 | Fri 17 Nov | 51-1 v PolandPoland 1-1 Czech Republic | European Championship Qualification Group E |
| 22 | Sat 25 Nov | 5 2-1 v BurnleyBurnley 1-2 West Ham United | Premier League |
| 23 | Sun 3 Dec | 5 1-1 v Crystal PalaceWest Ham United 1-1 Crystal Palace | Premier League |
| 24 | Thu 7 Dec | 52-1 v Tottenham HotspurTottenham Hotspur 1-2 West Ham United | Premier League |
| 25 | Sun 10 Dec | 50-5 v FulhamFulham 5-0 West Ham United | Premier League |
| 26 | Thu 14 Dec | 52-0 v SC FreiburgWest Ham United 2-0 SC Freiburg | UEFA Europa League Group A |
| 27 | Sun 17 Dec | 5 3-0 v Wolverhampton WanderersWest Ham United 3-0 Wolverhampton Wanderers | Premier League |
| 28 | Wed 20 Dec | 51-5 v LiverpoolLiverpool 5-1 West Ham United | Carabao Cup Quarter Final |
| 29 | Sat 23 Dec | 52-0 v Manchester UnitedWest Ham United 2-0 Manchester United | Premier League |
| 30 | Thu 28 Dec | 52-0 v ArsenalArsenal 0-2 West Ham United | Premier League |
| 31 | Sun 7 Jan | 51-1 v Bristol CityWest Ham United 1-1 Bristol City | Emirates FA Cup Third Round |
| 32 | Tue 16 Jan | 50-1 v Bristol CityBristol City 1-0 West Ham United | Emirates FA Cup Third Round Replay |
| 33 | Sun 21 Jan | 5 2-2 v Sheffield UnitedSheffield United 2-2 West Ham United | Premier League |
| 34 | Sun 4 Feb | 50-3 v Manchester UnitedManchester United 3-0 West Ham United | Premier League |
| 35 | Sun 11 Feb | 50-6 v ArsenalWest Ham United 0-6 Arsenal | Premier League |
| 36 | Sat 17 Feb | 5 0-2 v Nottingham ForestNottingham Forest 2-0 West Ham United | Premier League |
| 37 | Mon 26 Feb | 54-2 v BrentfordWest Ham United 4-2 Brentford | Premier League |
| 38 | Sat 2 Mar | 53-1 v EvertonEverton 1-3 West Ham United | Premier League |
| 39 | Thu 7 Mar | 50-1 v SC FreiburgSC Freiburg 1-0 West Ham United | UEFA Europa League Round of 16 |
| 40 | Sun 10 Mar | 52-2 v BurnleyWest Ham United 2-2 Burnley | Premier League |
| 41 | Thu 14 Mar | 55-0 v SC FreiburgWest Ham United 5-0 SC Freiburg | UEFA Europa League Round of 16 |
| 42 | Sun 17 Mar | 51-1 v Aston VillaWest Ham United 1-1 Aston Villa | Premier League |
| 43 | Sat 30 Mar | 53-4 v Newcastle UnitedNewcastle United 4-3 West Ham United | Premier League |
| 44 | Tue 2 Apr | 51-1 v Tottenham HotspurWest Ham United 1-1 Tottenham Hotspur | Premier League |
| 45 | Sat 6 Apr | 52-1 v Wolverhampton WanderersWolverhampton Wanderers 1-2 West Ham United | Premier League |
| 46 | Thu 11 Apr | 50-2 v Bayer 04 LeverkusenBayer 04 Leverkusen 2-0 West Ham United | UEFA Europa League Quarter Final |
| 47 | Sun 14 Apr | 50-2 v FulhamWest Ham United 0-2 Fulham | Premier League |
| 48 | Thu 18 Apr | 5 1-1 v Bayer 04 LeverkusenWest Ham United 1-1 Bayer 04 Leverkusen | UEFA Europa League Quarter Final |
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