| 1 | Sat 14 Aug 2021 | 20-0 v SC FreiburgArminia Bielefeld 0-0 SC Freiburg | German Bundesliga |
| 2 | Sat 21 Aug 2021 | 21-1 v Greuther FürthGreuther Fürth 1-1 Arminia Bielefeld | German Bundesliga |
| 3 | Sat 28 Aug 2021 | 21-1 v Eintracht FrankfurtArminia Bielefeld 1-1 Eintracht Frankfurt | German Bundesliga |
| 4 | Sat 18 Sep 2021 | 20-0 v 1899 HoffenheimArminia Bielefeld 0-0 1899 Hoffenheim | German Bundesliga |
| 5 | Sat 25 Sep 2021 | 20-1 v 1. FC Union Berlin1. FC Union Berlin 1-0 Arminia Bielefeld | German Bundesliga |
| 6 | Sun 3 Oct 2021 | 20-4 v Bayer 04 LeverkusenArminia Bielefeld 0-4 Bayer 04 Leverkusen | German Bundesliga |
| 7 | Sun 17 Oct 2021 | 21-1 v FC AugsburgFC Augsburg 1-1 Arminia Bielefeld | German Bundesliga |
| 8 | Sat 23 Oct 2021 | 21-3 v Borussia DortmundArminia Bielefeld 1-3 Borussia Dortmund | German Bundesliga |
| 9 | Sat 30 Oct 2021 | 21-2 v Mainz 05Arminia Bielefeld 1-2 Mainz 05 | German Bundesliga |
| 10 | Sat 6 Nov 2021 | 21-0 v VfB StuttgartVfB Stuttgart 0-1 Arminia Bielefeld | German Bundesliga |
| 11 | Sat 20 Nov 2021 | 2 2-2 v VfL WolfsburgArminia Bielefeld 2-2 VfL Wolfsburg | German Bundesliga |
| 12 | Sat 27 Nov 2021 | 20-1 v Bayern MunichBayern Munich 1-0 Arminia Bielefeld | German Bundesliga |
| 13 | Sat 4 Dec 2021 | 21-1 v 1. FC KölnArminia Bielefeld 1-1 1. FC Köln | German Bundesliga |
| 14 | Sat 11 Dec 2021 | 20-2 v Hertha BerlinHertha Berlin 2-0 Arminia Bielefeld | German Bundesliga |
| 15 | Tue 14 Dec 2021 | 22-0 v VfL BochumArminia Bielefeld 2-0 VfL Bochum | German Bundesliga |
| 16 | Sat 18 Dec 2021 | 22-0 v RB LeipzigRB Leipzig 0-2 Arminia Bielefeld | German Bundesliga |
| 17 | Sat 8 Jan 2022 | 22-2 v SC FreiburgSC Freiburg 2-2 Arminia Bielefeld | German Bundesliga |
| 18 | Sun 16 Jan 2022 | 22-2 v Greuther FürthArminia Bielefeld 2-2 Greuther Fürth | German Bundesliga |
| 19 | Fri 21 Jan 2022 | 22-0 v Eintracht FrankfurtEintracht Frankfurt 0-2 Arminia Bielefeld | German Bundesliga |
| 20 | Sun 13 Feb 2022 | 20-2 v 1899 Hoffenheim1899 Hoffenheim 2-0 Arminia Bielefeld | German Bundesliga |
| 21 | Sun 13 Mar 2022 | 20-1 v Borussia DortmundBorussia Dortmund 1-0 Arminia Bielefeld | German Bundesliga |
| 22 | Sat 19 Mar 2022 | 20-4 v Mainz 05Mainz 05 4-0 Arminia Bielefeld | German Bundesliga |
| 23 | Sat 2 Apr 2022 | 21-1 v VfB StuttgartArminia Bielefeld 1-1 VfB Stuttgart | German Bundesliga |
| 24 | Sat 9 Apr 2022 | 20-4 v VfL WolfsburgVfL Wolfsburg 4-0 Arminia Bielefeld | German Bundesliga |
| 25 | Sun 17 Apr 2022 | 20-3 v Bayern MunichArminia Bielefeld 0-3 Bayern Munich | German Bundesliga |
| 26 | Sat 23 Apr 2022 | 2 1-3 v 1. FC Köln1. FC Köln 3-1 Arminia Bielefeld | German Bundesliga |
| 27 | Sat 30 Apr 2022 | 21-1 v Hertha BerlinArminia Bielefeld 1-1 Hertha Berlin | German Bundesliga |
| 28 | Sat 14 May 2022 | 21-1 v RB LeipzigArminia Bielefeld 1-1 RB Leipzig | German Bundesliga |
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