| 1 | Sat 14 Aug 2021 | 42-3 v WatfordWatford 3-2 Aston Villa | Premier League |
| 2 | Sat 21 Aug 2021 | 42-0 v Newcastle UnitedAston Villa 2-0 Newcastle United | Premier League |
| 3 | Sat 28 Aug 2021 | 41-1 v BrentfordAston Villa 1-1 Brentford | Premier League |
| 4 | Sat 11 Sep 2021 | 40-3 v ChelseaChelsea 3-0 Aston Villa | Premier League |
| 5 | Sat 18 Sep 2021 | 43-0 v EvertonAston Villa 3-0 Everton | Premier League |
| 6 | Wed 22 Sep 2021 | 41-1 v ChelseaChelsea 1-1 Aston Villa | Carabao Cup Third Round |
| 7 | Sat 25 Sep 2021 | 41-0 v Manchester UnitedManchester United 0-1 Aston Villa | Premier League |
| 8 | Sun 3 Oct 2021 | 41-2 v Tottenham HotspurTottenham Hotspur 2-1 Aston Villa | Premier League |
| 9 | Sat 16 Oct 2021 | 42-3 v Wolverhampton WanderersAston Villa 2-3 Wolverhampton Wanderers | Premier League |
| 10 | Fri 22 Oct 2021 | 41-3 v ArsenalArsenal 3-1 Aston Villa | Premier League |
| 11 | Sun 31 Oct 2021 | 4 1-4 v West Ham UnitedAston Villa 1-4 West Ham United | Premier League |
| 12 | Sat 20 Nov 2021 | 4 2-0 v Brighton & Hove AlbionAston Villa 2-0 Brighton & Hove Albion | Premier League |
| 13 | Sat 27 Nov 2021 | 42-1 v Crystal PalaceCrystal Palace 1-2 Aston Villa | Premier League |
| 14 | Wed 1 Dec 2021 | 41-2 v Manchester CityAston Villa 1-2 Manchester City | Premier League |
| 15 | Sun 5 Dec 2021 | 42-1 v Leicester CityAston Villa 2-1 Leicester City | Premier League |
| 16 | Sat 11 Dec 2021 | 40-1 v LiverpoolLiverpool 1-0 Aston Villa | Premier League |
| 17 | Tue 14 Dec 2021 | 4 2-0 v Norwich CityNorwich City 0-2 Aston Villa | Premier League |
| 18 | Sun 26 Dec 2021 | 4 1-3 v ChelseaAston Villa 1-3 Chelsea | Premier League |
| 19 | Sun 2 Jan 2022 | 41-2 v BrentfordBrentford 2-1 Aston Villa | Premier League |
| 20 | Mon 10 Jan 2022 | 40-1 v Manchester UnitedManchester United 1-0 Aston Villa | Emirates FA Cup Third Round |
| 21 | Sat 15 Jan 2022 | 42-2 v Manchester UnitedAston Villa 2-2 Manchester United | Premier League |
| 22 | Sat 22 Jan 2022 | 41-0 v EvertonEverton 0-1 Aston Villa | Premier League |
| 23 | Wed 9 Feb 2022 | 4 3-3 v Leeds UnitedAston Villa 3-3 Leeds United | Premier League |
| 24 | Sat 26 Feb 2022 | 42-0 v Brighton & Hove AlbionBrighton & Hove Albion 0-2 Aston Villa | Premier League |
| 25 | Sat 19 Mar 2022 | 40-1 v ArsenalAston Villa 0-1 Arsenal | Premier League |
| 26 | Sat 2 Apr 2022 | 4 1-2 v Wolverhampton WanderersWolverhampton Wanderers 2-1 Aston Villa | Premier League |
| 27 | Sat 9 Apr 2022 | 40-4 v Tottenham HotspurAston Villa 0-4 Tottenham Hotspur | Premier League |
| 28 | Sat 23 Apr 2022 | 40-0 v Leicester CityLeicester City 0-0 Aston Villa | Premier League |
| 29 | Sat 7 May 2022 | 43-1 v BurnleyBurnley 1-3 Aston Villa | Premier League |
| 30 | Tue 10 May 2022 | 41-2 v LiverpoolAston Villa 1-2 Liverpool | Premier League |
| 31 | Sun 15 May 2022 | 41-1 v Crystal PalaceAston Villa 1-1 Crystal Palace | Premier League |
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