| 1 | Sat 11 Sep 2021 | 3 0-3 v PSV EindhovenAZ Alkmaar 0-3 PSV Eindhoven | Dutch Eredivisie |
| 2 | Thu 16 Sep 2021 | 32-2 v Randers FCRanders FC 2-2 AZ Alkmaar | UEFA Europa Conference League |
| 3 | Thu 23 Sep 2021 | 3 1-3 v FC TwenteFC Twente 3-1 AZ Alkmaar | Dutch Eredivisie |
| 4 | Sun 26 Sep 2021 | 35-0 v Go Ahead EaglesAZ Alkmaar 5-0 Go Ahead Eagles | Dutch Eredivisie |
| 5 | Thu 30 Sep 2021 | 3 1-0 v FK Baumit JablonecAZ Alkmaar 1-0 FK Baumit Jablonec | UEFA Europa Conference League |
| 6 | Sun 17 Oct 2021 | 35-1 v FC UtrechtAZ Alkmaar 5-1 FC Utrecht | Dutch Eredivisie |
| 7 | Thu 21 Oct 2021 | 31-0 v CFR Cluj-NapocaCFR Cluj-Napoca 0-1 AZ Alkmaar | UEFA Europa Conference League |
| 8 | Sun 24 Oct 2021 | 3 0-2 v FC GroningenFC Groningen 2-0 AZ Alkmaar | Dutch Eredivisie |
| 9 | Sat 30 Oct 2021 | 33-2 v PEC ZwolleAZ Alkmaar 3-2 PEC Zwolle | Dutch Eredivisie |
| 10 | Thu 4 Nov 2021 | 3 2-0 v CFR Cluj-NapocaAZ Alkmaar 2-0 CFR Cluj-Napoca | UEFA Europa Conference League |
| 11 | Sun 7 Nov 2021 | 30-1 v FeyenoordFeyenoord 1-0 AZ Alkmaar | Dutch Eredivisie |
| 12 | Sat 20 Nov 2021 | 31-1 v NEC NijmegenAZ Alkmaar 1-1 NEC Nijmegen | Dutch Eredivisie |
| 13 | Thu 25 Nov 2021 | 31-1 v FK Baumit JablonecFK Baumit Jablonec 1-1 AZ Alkmaar | UEFA Europa Conference League |
| 14 | Sun 28 Nov 2021 | 30-0 v VitesseVitesse 0-0 AZ Alkmaar | Dutch Eredivisie |
| 15 | Thu 2 Dec 2021 | 3 2-1 v Fortuna SittardAZ Alkmaar 2-1 Fortuna Sittard | Dutch Eredivisie |
| 16 | Sun 5 Dec 2021 | 33-1 v Sparta RotterdamAZ Alkmaar 3-1 Sparta Rotterdam | Dutch Eredivisie |
| 17 | Sun 12 Dec 2021 | 32-1 v AjaxAjax 1-2 AZ Alkmaar | Dutch Eredivisie |
| 18 | Sat 18 Dec 2021 | 34-1 v Willem IIAZ Alkmaar 4-1 Willem II | Dutch Eredivisie |
| 19 | Tue 21 Dec 2021 | 31-0 v FC GroningenAZ Alkmaar 1-0 FC Groningen | Dutch Eredivisie |
| 20 | Sun 16 Jan 2022 | 32-1 v Fortuna SittardFortuna Sittard 1-2 AZ Alkmaar | Dutch Eredivisie |
| 21 | Sat 5 Feb 2022 | 3 2-1 v PSV EindhovenPSV Eindhoven 1-2 AZ Alkmaar | Dutch Eredivisie |
| 22 | Sat 19 Feb 2022 | 32-1 v Heracles AlmeloAZ Alkmaar 2-1 Heracles Almelo | Dutch Eredivisie |
| 23 | Sun 27 Feb 2022 | 32-1 v FeyenoordAZ Alkmaar 2-1 Feyenoord | Dutch Eredivisie |
| 24 | Sun 6 Mar 2022 | 33-1 v NEC NijmegenNEC Nijmegen 1-3 AZ Alkmaar | Dutch Eredivisie |
| 25 | Sun 13 Mar 2022 | 3 0-1 v FC TwenteAZ Alkmaar 0-1 FC Twente | Dutch Eredivisie |
| 26 | Sun 20 Mar 2022 | 32-2 v Willem IIWillem II 2-2 AZ Alkmaar | Dutch Eredivisie |
| 27 | Sat 2 Apr 2022 | 33-1 v VitesseAZ Alkmaar 3-1 Vitesse | Dutch Eredivisie |
| 28 | Sun 10 Apr 2022 | 31-2 v PEC ZwollePEC Zwolle 2-1 AZ Alkmaar | Dutch Eredivisie |
| 29 | Sat 30 Apr 2022 | 31-1 v Sparta RotterdamSparta Rotterdam 1-1 AZ Alkmaar | Dutch Eredivisie |
| 30 | Sun 8 May 2022 | 32-2 v AjaxAZ Alkmaar 2-2 Ajax | Dutch Eredivisie |
| 31 | Wed 11 May 2022 | 32-2 v FC UtrechtFC Utrecht 2-2 AZ Alkmaar | Dutch Eredivisie |
| 32 | Sun 15 May 2022 | 31-3 v RKC WaalwijkAZ Alkmaar 1-3 RKC Waalwijk | Dutch Eredivisie |
| 33 | Thu 19 May 2022 | 32-3 v sc Heerenveensc Heerenveen 3-2 AZ Alkmaar | Dutch Eredivisie Play-off |
| 34 | Sun 22 May 2022 | 32-0 v sc HeerenveenAZ Alkmaar 2-0 sc Heerenveen | Dutch Eredivisie Play-off |
| 35 | Thu 26 May 2022 | 31-2 v VitesseVitesse 2-1 AZ Alkmaar | Dutch Eredivisie Play-off |
| 36 | Sun 29 May 2022 | 36-1 v VitesseAZ Alkmaar 6-1 Vitesse | Dutch Eredivisie Play-off |
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