| 1 | Sun 29 Aug 2021 | 12-1 v GetafeBarcelona 2-1 Getafe | Spanish La Liga |
| 2 | Tue 14 Sep 2021 | 10-3 v Bayern MunichBarcelona 0-3 Bayern Munich | UEFA Champions League Group E |
| 3 | Mon 20 Sep 2021 | 11-1 v GranadaBarcelona 1-1 Granada | Spanish La Liga |
| 4 | Thu 23 Sep 2021 | 10-0 v CádizCádiz 0-0 Barcelona | Spanish La Liga |
| 5 | Sun 26 Sep 2021 | 13-0 v LevanteBarcelona 3-0 Levante | Spanish La Liga |
| 6 | Wed 29 Sep 2021 | 10-3 v BenficaBenfica 3-0 Barcelona | UEFA Champions League Group E |
| 7 | Sat 2 Oct 2021 | 10-2 v Atlético MadridAtlético Madrid 2-0 Barcelona | Spanish La Liga |
| 8 | Sun 17 Oct 2021 | 13-1 v ValenciaBarcelona 3-1 Valencia | Spanish La Liga |
| 9 | Wed 20 Oct 2021 | 11-0 v Dynamo KievBarcelona 1-0 Dynamo Kiev | UEFA Champions League Group E |
| 10 | Sun 24 Oct 2021 | 11-2 v Real MadridBarcelona 1-2 Real Madrid | Spanish La Liga |
| 11 | Wed 27 Oct 2021 | 10-1 v Rayo VallecanoRayo Vallecano 1-0 Barcelona | Spanish La Liga |
| 12 | Sat 30 Oct 2021 | 11-1 v AlavésBarcelona 1-1 Alavés | Spanish La Liga |
| 13 | Tue 2 Nov 2021 | 11-0 v Dynamo KievDynamo Kiev 0-1 Barcelona | UEFA Champions League Group E |
| 14 | Sat 6 Nov 2021 | 1 3-3 v Celta VigoCelta Vigo 3-3 Barcelona | Spanish La Liga |
| 15 | Sat 20 Nov 2021 | 1 1-0 v EspanyolBarcelona 1-0 Espanyol | Spanish La Liga |
| 16 | Tue 23 Nov 2021 | 10-0 v BenficaBarcelona 0-0 Benfica | UEFA Champions League Group E |
| 17 | Sat 27 Nov 2021 | 13-1 v VillarrealVillarreal 1-3 Barcelona | Spanish La Liga |
| 18 | Sat 4 Dec 2021 | 10-1 v Real BetisBarcelona 0-1 Real Betis | Spanish La Liga |
| 19 | Wed 8 Dec 2021 | 10-3 v Bayern MunichBayern Munich 3-0 Barcelona | UEFA Champions League Group E |
| 20 | Sun 12 Dec 2021 | 1 2-2 v OsasunaOsasuna 2-2 Barcelona | Spanish La Liga |
| 21 | Sat 18 Dec 2021 | 13-2 v ElcheBarcelona 3-2 Elche | Spanish La Liga |
| 22 | Tue 21 Dec 2021 | 11-1 v SevillaSevilla 1-1 Barcelona | Spanish La Liga |
| 23 | Sun 2 Jan 2022 | 11-0 v MallorcaMallorca 0-1 Barcelona | Spanish La Liga |
| 24 | Sat 8 Jan 2022 | 11-1 v GranadaGranada 1-1 Barcelona | Spanish La Liga |
| 25 | Sun 23 Jan 2022 | 11-0 v AlavésAlavés 0-1 Barcelona | Spanish La Liga |
| 26 | Sun 6 Feb 2022 | 14-2 v Atlético MadridBarcelona 4-2 Atlético Madrid | Spanish La Liga |
| 27 | Sun 13 Feb 2022 | 12-2 v EspanyolEspanyol 2-2 Barcelona | Spanish La Liga |
| 28 | Thu 17 Feb 2022 | 11-1 v NapoliBarcelona 1-1 Napoli | UEFA Europa League Round of 32 |
| 29 | Sun 20 Feb 2022 | 14-1 v ValenciaValencia 1-4 Barcelona | Spanish La Liga |
| 30 | Thu 24 Feb 2022 | 14-2 v NapoliNapoli 2-4 Barcelona | UEFA Europa League Round of 32 |
| 31 | Sun 27 Feb 2022 | 14-0 v Athletic BilbaoBarcelona 4-0 Athletic Bilbao | Spanish La Liga |
| 32 | Sun 6 Mar 2022 | 12-1 v ElcheElche 1-2 Barcelona | Spanish La Liga |
| 33 | Thu 10 Mar 2022 | 10-0 v GalatasarayBarcelona 0-0 Galatasaray | UEFA Europa League Round of 16 |
| 34 | Sun 13 Mar 2022 | 14-0 v OsasunaBarcelona 4-0 Osasuna | Spanish La Liga |
| 35 | Thu 17 Mar 2022 | 12-1 v GalatasarayGalatasaray 1-2 Barcelona | UEFA Europa League Round of 16 |
| 36 | Sun 20 Mar 2022 | 14-0 v Real MadridReal Madrid 0-4 Barcelona | Spanish La Liga |
| 37 | Sun 3 Apr 2022 | 11-0 v SevillaBarcelona 1-0 Sevilla | Spanish La Liga |
| 38 | Thu 7 Apr 2022 | 11-1 v Eintracht FrankfurtEintracht Frankfurt 1-1 Barcelona | UEFA Europa League Quarter Final |
| 39 | Sun 10 Apr 2022 | 13-2 v LevanteLevante 2-3 Barcelona | Spanish La Liga |
| 40 | Thu 14 Apr 2022 | 12-3 v Eintracht FrankfurtBarcelona 2-3 Eintracht Frankfurt | UEFA Europa League Quarter Final |
| 41 | Mon 18 Apr 2022 | 10-1 v CádizBarcelona 0-1 Cádiz | Spanish La Liga |
| 42 | Thu 21 Apr 2022 | 11-0 v Real SociedadReal Sociedad 0-1 Barcelona | Spanish La Liga |
| 43 | Sun 24 Apr 2022 | 10-1 v Rayo VallecanoBarcelona 0-1 Rayo Vallecano | Spanish La Liga |
| 44 | Sun 1 May 2022 | 12-1 v MallorcaBarcelona 2-1 Mallorca | Spanish La Liga |
| 45 | Tue 10 May 2022 | 13-1 v Celta VigoBarcelona 3-1 Celta Vigo | Spanish La Liga |
| 46 | Sun 15 May 2022 | 10-0 v GetafeGetafe 0-0 Barcelona | Spanish La Liga |
| 47 | Sun 22 May 2022 | 10-2 v VillarrealBarcelona 0-2 Villarreal | Spanish La Liga |
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