| 1 | Wed 2 Feb 2022 | 280-1 v Cardiff CityBarnsley 0-1 Cardiff City | Sky Bet Championship |
| 2 | Tue 8 Feb 2022 | 281-2 v Luton TownLuton Town 2-1 Barnsley | Sky Bet Championship |
| 3 | Sat 12 Feb 2022 | 28 1-0 v Queens Park RangersBarnsley 1-0 Queens Park Rangers | Sky Bet Championship |
| 4 | Sat 19 Feb 2022 | 28 0-1 v Coventry CityCoventry City 1-0 Barnsley | Sky Bet Championship |
| 5 | Tue 22 Feb 2022 | 282-0 v Hull CityHull City 0-2 Barnsley | Sky Bet Championship |
| 6 | Sat 26 Feb 2022 | 283-2 v MiddlesbroughBarnsley 3-2 Middlesbrough | Sky Bet Championship |
| 7 | Sat 5 Mar 2022 | 280-2 v Derby CountyDerby County 2-0 Barnsley | Sky Bet Championship |
| 8 | Tue 8 Mar 2022 | 28 1-1 v Stoke CityBarnsley 1-1 Stoke City | Sky Bet Championship |
| 9 | Sat 12 Mar 2022 | 28 1-1 v FulhamBarnsley 1-1 Fulham | Sky Bet Championship |
| 10 | Tue 15 Mar 2022 | 282-0 v Bristol CityBarnsley 2-0 Bristol City | Sky Bet Championship |
| 11 | Sat 19 Mar 2022 | 280-2 v Sheffield UnitedSheffield United 2-0 Barnsley | Sky Bet Championship |
| 12 | Sat 2 Apr 2022 | 281-1 v ReadingBarnsley 1-1 Reading | Sky Bet Championship |
| 13 | Sat 9 Apr 2022 | 281-4 v MillwallMillwall 4-1 Barnsley | Sky Bet Championship |
| 14 | Fri 15 Apr 2022 | 281-1 v Swansea CitySwansea City 1-1 Barnsley | Sky Bet Championship |
| 15 | Mon 18 Apr 2022 | 280-2 v Peterborough UnitedBarnsley 0-2 Peterborough United | Sky Bet Championship |
| 16 | Fri 22 Apr 2022 | 281-2 v Huddersfield TownHuddersfield Town 2-1 Barnsley | Sky Bet Championship |
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