| 1 | 7/8/2021 | 11-1 v Cardiff CityCardiff City 1-1 Barnsley | Sky Bet Championship |
| 2 | 14/8/2021 | 11-0 v Coventry CityBarnsley 1-0 Coventry City | Sky Bet Championship |
| 3 | 17/8/2021 | 10-1 v Luton TownBarnsley 0-1 Luton Town | Sky Bet Championship |
| 4 | 21/8/2021 | 12-2 v Queens Park RangersQueens Park Rangers 2-2 Barnsley | Sky Bet Championship |
| 5 | 28/8/2021 | 11-1 v Birmingham CityBarnsley 1-1 Birmingham City | Sky Bet Championship |
| 6 | 11/9/2021 | 10-3 v AFC BournemouthAFC Bournemouth 3-0 Barnsley | Sky Bet Championship |
| 7 | 15/9/2021 | 11-1 v Stoke CityStoke City 1-1 Barnsley | Sky Bet Championship |
| 8 | 18/9/2021 | 10-0 v Blackburn RoversBarnsley 0-0 Blackburn Rovers | Sky Bet Championship |
| 9 | 25/9/2021 | 10-1 v BlackpoolBlackpool 1-0 Barnsley | Sky Bet Championship |
| 10 | 29/9/2021 | 11-3 v Nottingham ForestBarnsley 1-3 Nottingham Forest | Sky Bet Championship |
| 11 | 2/10/2021 | 10-1 v MillwallBarnsley 0-1 Millwall | Sky Bet Championship |
| 12 | 16/10/2021 | 10-1 v ReadingReading 1-0 Barnsley | Sky Bet Championship |
| 13 | 20/10/2021 | 10-2 v MiddlesbroughMiddlesbrough 2-0 Barnsley | Sky Bet Championship |
| 14 | 24/10/2021 | 12-3 v Sheffield UnitedBarnsley 2-3 Sheffield United | Sky Bet Championship |
| 15 | 30/10/2021 | 11-2 v Bristol CityBristol City 2-1 Barnsley | Sky Bet Championship |
| 16 | 3/11/2021 | 12-1 v Derby CountyBarnsley 2-1 Derby County | Sky Bet Championship |
| 17 | 6/11/2021 | 10-2 v Hull CityBarnsley 0-2 Hull City | Sky Bet Championship |
| 18 | 20/11/2021 | 11-4 v FulhamFulham 4-1 Barnsley | Sky Bet Championship |
| 19 | 24/11/2021 | 10-2 v Swansea CityBarnsley 0-2 Swansea City | Sky Bet Championship |
| 20 | 27/11/2021 | 10-0 v Peterborough UnitedPeterborough United 0-0 Barnsley | Sky Bet Championship |
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