| 1 | Sun 20 Sep 2020 | 20 0-0 v VfL WolfsburgVfL Wolfsburg 0-0 Bayer 04 Leverkusen | German Bundesliga |
| 2 | Sat 26 Sep 2020 | 201-1 v RB LeipzigBayer 04 Leverkusen 1-1 RB Leipzig | German Bundesliga |
| 3 | Sat 3 Oct 2020 | 20 1-1 v VfB StuttgartVfB Stuttgart 1-1 Bayer 04 Leverkusen | German Bundesliga |
| 4 | Sat 17 Oct 2020 | 201-0 v Mainz 05Mainz 05 0-1 Bayer 04 Leverkusen | German Bundesliga |
| 5 | Fri 15 Jan 2021 | 200-1 v 1. FC Union Berlin1. FC Union Berlin 1-0 Bayer 04 Leverkusen | German Bundesliga |
| 6 | Tue 19 Jan 2021 | 202-1 v Borussia DortmundBayer 04 Leverkusen 2-1 Borussia Dortmund | German Bundesliga |
| 7 | Sat 23 Jan 2021 | 200-1 v VfL WolfsburgBayer 04 Leverkusen 0-1 VfL Wolfsburg | German Bundesliga |
| 8 | Sat 30 Jan 2021 | 200-1 v RB LeipzigRB Leipzig 1-0 Bayer 04 Leverkusen | German Bundesliga |
| 9 | Sat 6 Feb 2021 | 205-2 v VfB StuttgartBayer 04 Leverkusen 5-2 VfB Stuttgart | German Bundesliga |
| 10 | Sat 13 Feb 2021 | 202-2 v Mainz 05Bayer 04 Leverkusen 2-2 Mainz 05 | German Bundesliga |
| 11 | Thu 18 Feb 2021 | 203-4 v Young BoysYoung Boys 4-3 Bayer 04 Leverkusen | Europa League Round of 32 |
| 12 | Sun 21 Feb 2021 | 20 1-1 v FC AugsburgFC Augsburg 1-1 Bayer 04 Leverkusen | German Bundesliga |
| 13 | Thu 25 Feb 2021 | 200-2 v Young BoysBayer 04 Leverkusen 0-2 Young Boys | Europa League Round of 32 |
| 14 | Sun 28 Feb 2021 | 20 1-2 v SC FreiburgBayer 04 Leverkusen 1-2 SC Freiburg | German Bundesliga |
| 15 | Sat 6 Mar 2021 | 201-0 v Borussia MönchengladbachBorussia Mönchengladbach 0-1 Bayer 04 Leverkusen | German Bundesliga |
| 16 | Sun 14 Mar 2021 | 201-2 v Arminia BielefeldBayer 04 Leverkusen 1-2 Arminia Bielefeld | German Bundesliga |
| 17 | Sun 21 Mar 2021 | 200-3 v Hertha BerlinHertha Berlin 3-0 Bayer 04 Leverkusen | German Bundesliga |
| 18 | Sat 3 Apr 2021 | 202-1 v FC Schalke 04Bayer 04 Leverkusen 2-1 FC Schalke 04 | German Bundesliga |
| 19 | Mon 12 Apr 2021 | 200-0 v 1899 Hoffenheim1899 Hoffenheim 0-0 Bayer 04 Leverkusen | German Bundesliga |
| 20 | Sat 17 Apr 2021 | 203-0 v 1. FC KölnBayer 04 Leverkusen 3-0 1. FC Köln | German Bundesliga |
| 21 | Tue 20 Apr 2021 | 200-2 v Bayern MunichBayern Munich 2-0 Bayer 04 Leverkusen | German Bundesliga |
| 22 | Sat 15 May 2021 | 201-1 v 1. FC Union BerlinBayer 04 Leverkusen 1-1 1. FC Union Berlin | German Bundesliga |
| 23 | Sat 22 May 2021 | 201-3 v Borussia DortmundBorussia Dortmund 3-1 Bayer 04 Leverkusen | German Bundesliga |
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