| 1 | 7/8/2021 | 143-1 v Leek TownBuxton 3-1 Leek Town | Friendly |
| 2 | 14/8/2021 | 163-0 v Bamber BridgeBuxton 3-0 Bamber Bridge | Northern Premier League - Premier Division |
| 3 | 17/8/2021 | 173-0 v Grantham TownGrantham Town 0-3 Buxton | Northern Premier League - Premier Division |
| 4 | 24/8/2021 | 163-1 v MickleoverBuxton 3-1 Mickleover | Northern Premier League - Premier Division |
| 5 | 28/8/2021 | 162-0 v Stalybridge CelticBuxton 2-0 Stalybridge Celtic | Northern Premier League - Premier Division |
| 6 | 30/8/2021 | 161-0 v Stafford RangersStafford Rangers 0-1 Buxton | Northern Premier League - Premier Division |
| 7 | 4/9/2021 | 162-2 v Sherwood CollierySherwood Colliery 2-2 Buxton | Emirates FA Cup First Qualifying Round |
| 8 | 7/9/2021 | 165-1 v Sherwood CollieryBuxton 5-1 Sherwood Colliery | Emirates FA Cup First Qualifying Round Replay |
| 9 | 14/9/2021 | 162-2 v Warrington TownWarrington Town 2-2 Buxton | Northern Premier League - Premier Division |
| 10 | 18/9/2021 | 164-0 v Rushall OlympicBuxton 4-0 Rushall Olympic | Emirates FA Cup Second Qualifying Round |
| 11 | 25/9/2021 | 172-2 v Morpeth TownBuxton 2-2 Morpeth Town | Northern Premier League - Premier Division |
| 12 | 28/9/2021 | 170-0 v Gainsborough TrinityGainsborough Trinity 0-0 Buxton | Northern Premier League - Premier Division |
| 13 | 2/10/2021 | 176-1 v City of LiverpoolCity of Liverpool 1-6 Buxton | Emirates FA Cup Third Qualifying Round |
| 14 | 5/10/2021 | 164-1 v Whitby TownBuxton 4-1 Whitby Town | Northern Premier League - Premier Division |
| 15 | 9/10/2021 | 153-2 v RadcliffeRadcliffe 2-3 Buxton | Northern Premier League - Premier Division |
| 16 | 16/10/2021 | 172-2 v Kettering TownKettering Town 2-2 Buxton | Emirates FA Cup Fourth Qualifying Round |
| 17 | 19/10/2021 | 173-1 v Kettering TownBuxton 3-1 Kettering Town | Emirates FA Cup Fourth Qualifying Round Replay |
| 18 | 23/10/2021 | 171-0 v South ShieldsSouth Shields 0-1 Buxton | Northern Premier League - Premier Division |
| 19 | 30/10/2021 | 161-2 v ColneBuxton 1-2 Colne | Buildbase FA Trophy Third Qualifying Round |
| 20 | 6/11/2021 | 151-0 v York CityYork City 0-1 Buxton | Emirates FA Cup First Round |
| 21 | 9/11/2021 | 152-0 v Atherton CollieriesBuxton 2-0 Atherton Collieries | Northern Premier League - Premier Division |
| 22 | 13/11/2021 | 163-0 v Hyde UnitedBuxton 3-0 Hyde United | Northern Premier League - Premier Division |
| 23 | 20/11/2021 | 170-1 v Lancaster CityLancaster City 1-0 Buxton | Northern Premier League - Premier Division |
| 24 | 23/11/2021 | 171-1 v Nantwich TownBuxton 1-1 Nantwich Town | Northern Premier League - Premier Division |
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