| 1 | Sat 14 Aug 2021 | 11-1 v LevanteCádiz 1-1 Levante | Spanish La Liga |
| 2 | Fri 20 Aug 2021 | 11-1 v Real BetisReal Betis 1-1 Cádiz | Spanish La Liga |
| 3 | Sun 29 Aug 2021 | 12-3 v OsasunaCádiz 2-3 Osasuna | Spanish La Liga |
| 4 | Sun 12 Sep 2021 | 10-2 v Real SociedadCádiz 0-2 Real Sociedad | Spanish La Liga |
| 5 | Fri 17 Sep 2021 | 12-1 v Celta VigoCelta Vigo 1-2 Cádiz | Spanish La Liga |
| 6 | Thu 23 Sep 2021 | 10-0 v BarcelonaCádiz 0-0 Barcelona | Spanish La Liga |
| 7 | Sun 26 Sep 2021 | 11-3 v Rayo VallecanoRayo Vallecano 3-1 Cádiz | Spanish La Liga |
| 8 | Sat 2 Oct 2021 | 10-0 v ValenciaCádiz 0-0 Valencia | Spanish La Liga |
| 9 | Mon 18 Oct 2021 | 10-2 v EspanyolEspanyol 2-0 Cádiz | Spanish La Liga |
| 10 | Sat 23 Oct 2021 | 10-2 v AlavésCádiz 0-2 Alavés | Spanish La Liga |
| 11 | Tue 26 Oct 2021 | 13-3 v VillarrealVillarreal 3-3 Cádiz | Spanish La Liga |
| 12 | Sun 31 Oct 2021 | 11-1 v MallorcaCádiz 1-1 Mallorca | Spanish La Liga |
| 13 | Fri 5 Nov 2021 | 11-0 v Athletic BilbaoAthletic Bilbao 0-1 Cádiz | Spanish La Liga |
| 14 | Sun 21 Nov 2021 | 10-4 v GetafeGetafe 4-0 Cádiz | Spanish La Liga |
| 15 | Sun 28 Nov 2021 | 11-4 v Atlético MadridCádiz 1-4 Atlético Madrid | Spanish La Liga |
| 16 | Sun 5 Dec 2021 | 11-3 v ElcheElche 3-1 Cádiz | Spanish La Liga |
| 17 | Mon 13 Dec 2021 | 11-1 v GranadaCádiz 1-1 Granada | Spanish La Liga |
| 18 | Sun 19 Dec 2021 | 10-0 v Real MadridReal Madrid 0-0 Cádiz | Spanish La Liga |
| 19 | Mon 3 Jan 2022 | 10-1 v SevillaCádiz 0-1 Sevilla | Spanish La Liga |
| 20 | Sun 9 Jan 2022 | 10-2 v OsasunaOsasuna 2-0 Cádiz | Spanish La Liga |
| 21 | Tue 18 Jan 2022 | 1 2-2 v EspanyolCádiz 2-2 Espanyol | Spanish La Liga |
| 22 | Sat 22 Jan 2022 | 1 2-0 v LevanteLevante 0-2 Cádiz | Spanish La Liga |
| 23 | Sat 5 Feb 2022 | 1 1-2 v MallorcaMallorca 2-1 Cádiz | Spanish La Liga |
| 24 | Sat 12 Feb 2022 | 1 0-0 v Celta VigoCádiz 0-0 Celta Vigo | Spanish La Liga |
| 25 | Sat 19 Feb 2022 | 11-1 v GetafeCádiz 1-1 Getafe | Spanish La Liga |
| 26 | Mon 28 Feb 2022 | 10-0 v GranadaGranada 0-0 Cádiz | Spanish La Liga |
| 27 | Sun 6 Mar 2022 | 12-0 v Rayo VallecanoCádiz 2-0 Rayo Vallecano | Spanish La Liga |
| 28 | Fri 11 Mar 2022 | 11-2 v Atlético MadridAtlético Madrid 2-1 Cádiz | Spanish La Liga |
| 29 | Sun 20 Mar 2022 | 11-0 v VillarrealCádiz 1-0 Villarreal | Spanish La Liga |
| 30 | Sun 3 Apr 2022 | 10-0 v ValenciaValencia 0-0 Cádiz | Spanish La Liga |
| 31 | Sat 9 Apr 2022 | 11-2 v Real BetisCádiz 1-2 Real Betis | Spanish La Liga |
| 32 | Mon 18 Apr 2022 | 11-0 v BarcelonaBarcelona 0-1 Cádiz | Spanish La Liga |
| 33 | Thu 21 Apr 2022 | 12-3 v Athletic BilbaoCádiz 2-3 Athletic Bilbao | Spanish La Liga |
| 34 | Fri 29 Apr 2022 | 11-1 v SevillaSevilla 1-1 Cádiz | Spanish La Liga |
| 35 | Sat 7 May 2022 | 13-0 v ElcheCádiz 3-0 Elche | Spanish La Liga |
| 36 | Thu 12 May 2022 | 10-3 v Real SociedadReal Sociedad 3-0 Cádiz | Spanish La Liga |
| 37 | Sun 15 May 2022 | 11-1 v Real MadridCádiz 1-1 Real Madrid | Spanish La Liga |
| 38 | Sun 22 May 2022 | 11-0 v AlavésAlavés 0-1 Cádiz | Spanish La Liga |
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