| 1 | Sat 7 Aug 2021 | 21-1 v Oxford UnitedCambridge United 1-1 Oxford United | Sky Bet League One |
| 2 | Tue 10 Aug 2021 | 20-0 v Swindon TownCambridge United 0-0 Swindon Town | Carabao Cup First Round |
| 3 | Sat 14 Aug 2021 | 21-2 v Accrington StanleyAccrington Stanley 2-1 Cambridge United | Sky Bet League One |
| 4 | Tue 17 Aug 2021 | 2 1-1 v Plymouth ArgylePlymouth Argyle 1-1 Cambridge United | Sky Bet League One |
| 5 | Sat 21 Aug 2021 | 23-0 v Burton AlbionCambridge United 3-0 Burton Albion | Sky Bet League One |
| 6 | Tue 24 Aug 2021 | 21-3 v MillwallMillwall 3-1 Cambridge United | Carabao Cup Second Round |
| 7 | Sat 28 Aug 2021 | 21-0 v Bolton WanderersCambridge United 1-0 Bolton Wanderers | Sky Bet League One |
| 8 | Sat 11 Sep 2021 | 2 1-5 v Lincoln CityCambridge United 1-5 Lincoln City | Sky Bet League One |
| 9 | Sat 18 Sep 2021 | 2 2-1 v PortsmouthPortsmouth 1-2 Cambridge United | Sky Bet League One |
| 10 | Sat 25 Sep 2021 | 22-2 v Fleetwood TownCambridge United 2-2 Fleetwood Town | Sky Bet League One |
| 11 | Tue 28 Sep 2021 | 20-2 v GillinghamCambridge United 0-2 Gillingham | Sky Bet League One |
| 12 | Sat 2 Oct 2021 | 22-2 v Crewe AlexandraCrewe Alexandra 2-2 Cambridge United | Sky Bet League One |
| 13 | Sat 16 Oct 2021 | 22-2 v Ipswich TownCambridge United 2-2 Ipswich Town | Sky Bet League One |
| 14 | Tue 19 Oct 2021 | 21-1 v Sheffield WednesdayCambridge United 1-1 Sheffield Wednesday | Sky Bet League One |
| 15 | Sat 23 Oct 2021 | 21-4 v Shrewsbury TownShrewsbury Town 4-1 Cambridge United | Sky Bet League One |
| 16 | Tue 26 Oct 2021 | 21-1 v Doncaster RoversDoncaster Rovers 1-1 Cambridge United | Sky Bet League One |
| 17 | Sat 30 Oct 2021 | 2 1-0 v AFC WimbledonCambridge United 1-0 AFC Wimbledon | Sky Bet League One |
| 18 | Sat 6 Nov 2021 | 22-2 v Northampton TownNorthampton Town 2-2 Cambridge United | Emirates FA Cup First Round |
| 19 | Sat 13 Nov 2021 | 2 1-4 v Milton Keynes DonsMilton Keynes Dons 4-1 Cambridge United | Sky Bet League One |
| 20 | Tue 16 Nov 2021 | 23-1 v Northampton TownCambridge United 3-1 Northampton Town | Emirates FA Cup First Round Replay |
| 21 | Sat 20 Nov 2021 | 21-3 v Rotherham UnitedRotherham United 3-1 Cambridge United | Sky Bet League One |
| 22 | Tue 23 Nov 2021 | 22-2 v Wigan AthleticCambridge United 2-2 Wigan Athletic | Sky Bet League One |
| 23 | Sat 27 Nov 2021 | 21-2 v SunderlandCambridge United 1-2 Sunderland | Sky Bet League One |
| 24 | Sat 4 Dec 2021 | 22-1 v Exeter CityCambridge United 2-1 Exeter City | Emirates FA Cup Second Round |
| 25 | Tue 7 Dec 2021 | 25-0 v Cheltenham TownCheltenham Town 0-5 Cambridge United | Sky Bet League One |
| 26 | Sat 11 Dec 2021 | 20-2 v Charlton AthleticCharlton Athletic 2-0 Cambridge United | Sky Bet League One |
| 27 | Sat 18 Dec 2021 | 20-1 v Rotherham UnitedCambridge United 0-1 Rotherham United | Sky Bet League One |
| 28 | Mon 3 Jan 2022 | 20-0 v PortsmouthCambridge United 0-0 Portsmouth | Sky Bet League One |
| 29 | Sat 8 Jan 2022 | 21-0 v Newcastle UnitedNewcastle United 0-1 Cambridge United | Emirates FA Cup Third Round |
| 30 | Sat 22 Jan 2022 | 21-0 v Crewe AlexandraCambridge United 1-0 Crewe Alexandra | Sky Bet League One |
| 31 | Tue 25 Jan 2022 | 21-1 v Rotherham UnitedRotherham United 1-1 Cambridge United | Papa John’s Trophy Quarter Final |
| 32 | Sat 29 Jan 2022 | 21-1 v Fleetwood TownFleetwood Town 1-1 Cambridge United | Sky Bet League One |
| 33 | Tue 1 Feb 2022 | 20-2 v Bolton WanderersBolton Wanderers 2-0 Cambridge United | Sky Bet League One |
| 34 | Sat 5 Feb 2022 | 20-3 v Luton TownCambridge United 0-3 Luton Town | Emirates FA Cup Fourth Round |
| 35 | Tue 8 Feb 2022 | 20-1 v GillinghamGillingham 1-0 Cambridge United | Sky Bet League One |
| 36 | Sat 12 Feb 2022 | 22-2 v Burton AlbionBurton Albion 2-2 Cambridge United | Sky Bet League One |
| 37 | Sat 19 Feb 2022 | 22-0 v Accrington StanleyCambridge United 2-0 Accrington Stanley | Sky Bet League One |
| 38 | Tue 22 Feb 2022 | 2 2-0 v Plymouth ArgyleCambridge United 2-0 Plymouth Argyle | Sky Bet League One |
| 39 | Sat 26 Feb 2022 | 22-4 v Oxford UnitedOxford United 4-2 Cambridge United | Sky Bet League One |
| 40 | Tue 1 Mar 2022 | 20-3 v Wycombe WanderersWycombe Wanderers 3-0 Cambridge United | Sky Bet League One |
| 41 | Sat 5 Mar 2022 | 20-0 v Shrewsbury TownCambridge United 0-0 Shrewsbury Town | Sky Bet League One |
| 42 | Sat 12 Mar 2022 | 20-6 v Sheffield WednesdaySheffield Wednesday 6-0 Cambridge United | Sky Bet League One |
| 43 | Sat 19 Mar 2022 | 20-1 v Milton Keynes DonsCambridge United 0-1 Milton Keynes Dons | Sky Bet League One |
| 44 | Sat 26 Mar 2022 | 21-0 v AFC WimbledonAFC Wimbledon 0-1 Cambridge United | Sky Bet League One |
| 45 | Sat 2 Apr 2022 | 21-0 v Ipswich TownIpswich Town 0-1 Cambridge United | Sky Bet League One |
| 46 | Tue 5 Apr 2022 | 21-4 v Wycombe WanderersCambridge United 1-4 Wycombe Wanderers | Sky Bet League One |
| 47 | Sat 16 Apr 2022 | 2 2-1 v Wigan AthleticWigan Athletic 1-2 Cambridge United | Sky Bet League One |
| 48 | Sat 23 Apr 2022 | 21-5 v SunderlandSunderland 5-1 Cambridge United | Sky Bet League One |
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