| 1 | Tue 10 Aug 2021 | 16 0-0 v Swindon TownCambridge United 0-0 Swindon Town | Carabao Cup First Round |
| 2 | Sat 14 Aug 2021 | 161-2 v Accrington StanleyAccrington Stanley 2-1 Cambridge United | Sky Bet League One |
| 3 | Tue 17 Aug 2021 | 161-1 v Plymouth ArgylePlymouth Argyle 1-1 Cambridge United | Sky Bet League One |
| 4 | Tue 24 Aug 2021 | 161-3 v MillwallMillwall 3-1 Cambridge United | Carabao Cup Second Round |
| 5 | Tue 31 Aug 2021 | 164-1 v Oxford UnitedCambridge United 4-1 Oxford United | Papa John’s Trophy |
| 6 | Sat 11 Sep 2021 | 161-5 v Lincoln CityCambridge United 1-5 Lincoln City | Sky Bet League One |
| 7 | Tue 28 Sep 2021 | 160-2 v GillinghamCambridge United 0-2 Gillingham | Sky Bet League One |
| 8 | Tue 19 Oct 2021 | 161-1 v Sheffield WednesdayCambridge United 1-1 Sheffield Wednesday | Sky Bet League One |
| 9 | Sat 23 Oct 2021 | 161-4 v Shrewsbury TownShrewsbury Town 4-1 Cambridge United | Sky Bet League One |
| 10 | Tue 26 Oct 2021 | 161-1 v Doncaster RoversDoncaster Rovers 1-1 Cambridge United | Sky Bet League One |
| 11 | Sat 30 Oct 2021 | 161-0 v AFC WimbledonCambridge United 1-0 AFC Wimbledon | Sky Bet League One |
| 12 | Tue 2 Nov 2021 | 162-0 v MorecambeMorecambe 0-2 Cambridge United | Sky Bet League One |
| 13 | Sat 6 Nov 2021 | 162-2 v Northampton TownNorthampton Town 2-2 Cambridge United | Emirates FA Cup First Round |
| 14 | Tue 9 Nov 2021 | 16 0-1 v StevenageStevenage 1-0 Cambridge United | Papa John’s Trophy |
| 15 | Sat 13 Nov 2021 | 161-4 v Milton Keynes DonsMilton Keynes Dons 4-1 Cambridge United | Sky Bet League One |
| 16 | Tue 16 Nov 2021 | 163-1 v Northampton TownCambridge United 3-1 Northampton Town | Emirates FA Cup First Round Replay |
| 17 | Sat 20 Nov 2021 | 161-3 v Rotherham UnitedRotherham United 3-1 Cambridge United | Sky Bet League One |
| 18 | Tue 23 Nov 2021 | 16 2-2 v Wigan AthleticCambridge United 2-2 Wigan Athletic | Sky Bet League One |
| 19 | Sat 4 Dec 2021 | 162-1 v Exeter CityCambridge United 2-1 Exeter City | Emirates FA Cup Second Round |
| 20 | Tue 7 Dec 2021 | 165-0 v Cheltenham TownCheltenham Town 0-5 Cambridge United | Sky Bet League One |
| 21 | Sat 11 Dec 2021 | 160-2 v Charlton AthleticCharlton Athletic 2-0 Cambridge United | Sky Bet League One |
| 22 | Sat 18 Dec 2021 | 160-1 v Rotherham UnitedCambridge United 0-1 Rotherham United | Sky Bet League One |
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