| 1 | Sat 7 Aug 2021 | 8 1-1 v Oxford UnitedCambridge United 1-1 Oxford United | Sky Bet League One |
| 2 | Sat 14 Aug 2021 | 81-2 v Accrington StanleyAccrington Stanley 2-1 Cambridge United | Sky Bet League One |
| 3 | Tue 17 Aug 2021 | 8 1-1 v Plymouth ArgylePlymouth Argyle 1-1 Cambridge United | Sky Bet League One |
| 4 | Sat 21 Aug 2021 | 83-0 v Burton AlbionCambridge United 3-0 Burton Albion | Sky Bet League One |
| 5 | Sat 28 Aug 2021 | 8 1-0 v Bolton WanderersCambridge United 1-0 Bolton Wanderers | Sky Bet League One |
| 6 | Sat 11 Sep 2021 | 81-5 v Lincoln CityCambridge United 1-5 Lincoln City | Sky Bet League One |
| 7 | Sat 18 Sep 2021 | 82-1 v PortsmouthPortsmouth 1-2 Cambridge United | Sky Bet League One |
| 8 | Sat 25 Sep 2021 | 82-2 v Fleetwood TownCambridge United 2-2 Fleetwood Town | Sky Bet League One |
| 9 | Tue 28 Sep 2021 | 80-2 v GillinghamCambridge United 0-2 Gillingham | Sky Bet League One |
| 10 | Sat 2 Oct 2021 | 82-2 v Crewe AlexandraCrewe Alexandra 2-2 Cambridge United | Sky Bet League One |
| 11 | Sat 8 Jan 2022 | 81-0 v Newcastle UnitedNewcastle United 0-1 Cambridge United | Emirates FA Cup Third Round |
| 12 | Tue 11 Jan 2022 | 82-1 v PortsmouthCambridge United 2-1 Portsmouth | Papa John’s Trophy Third Round |
| 13 | Tue 18 Jan 2022 | 83-1 v Doncaster RoversCambridge United 3-1 Doncaster Rovers | Sky Bet League One |
| 14 | Tue 8 Feb 2022 | 80-1 v GillinghamGillingham 1-0 Cambridge United | Sky Bet League One |
| 15 | Sat 19 Feb 2022 | 82-0 v Accrington StanleyCambridge United 2-0 Accrington Stanley | Sky Bet League One |
| 16 | Tue 22 Feb 2022 | 82-0 v Plymouth ArgyleCambridge United 2-0 Plymouth Argyle | Sky Bet League One |
| 17 | Sat 26 Feb 2022 | 8 2-4 v Oxford UnitedOxford United 4-2 Cambridge United | Sky Bet League One |
| 18 | Sat 12 Mar 2022 | 80-6 v Sheffield WednesdaySheffield Wednesday 6-0 Cambridge United | Sky Bet League One |
| 19 | Sat 19 Mar 2022 | 80-1 v Milton Keynes DonsCambridge United 0-1 Milton Keynes Dons | Sky Bet League One |
| 20 | Sat 16 Apr 2022 | 82-1 v Wigan AthleticWigan Athletic 1-2 Cambridge United | Sky Bet League One |
| 21 | Tue 19 Apr 2022 | 80-2 v Charlton AthleticCambridge United 0-2 Charlton Athletic | Sky Bet League One |
| 22 | Sat 23 Apr 2022 | 81-5 v SunderlandSunderland 5-1 Cambridge United | Sky Bet League One |
| 23 | Sat 30 Apr 2022 | 8 2-2 v Cheltenham TownCambridge United 2-2 Cheltenham Town | Sky Bet League One |
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