| 1 | 7/8/2021 | 11-1 v Oxford UnitedCambridge United 1-1 Oxford United | Sky Bet League One |
| 2 | 10/8/2021 | 10-0 v Swindon TownCambridge United 0-0 Swindon Town | Carabao Cup First Round |
| 3 | 14/8/2021 | 11-2 v Accrington StanleyAccrington Stanley 2-1 Cambridge United | Sky Bet League One |
| 4 | 17/8/2021 | 11-1 v Plymouth ArgylePlymouth Argyle 1-1 Cambridge United | Sky Bet League One |
| 5 | 21/8/2021 | 13-0 v Burton AlbionCambridge United 3-0 Burton Albion | Sky Bet League One |
| 6 | 24/8/2021 | 11-3 v MillwallMillwall 3-1 Cambridge United | Carabao Cup Second Round |
| 7 | 28/8/2021 | 11-0 v Bolton WanderersCambridge United 1-0 Bolton Wanderers | Sky Bet League One |
| 8 | 11/9/2021 | 11-5 v Lincoln CityCambridge United 1-5 Lincoln City | Sky Bet League One |
| 9 | 18/9/2021 | 12-1 v PortsmouthPortsmouth 1-2 Cambridge United | Sky Bet League One |
| 10 | 25/9/2021 | 12-2 v Fleetwood TownCambridge United 2-2 Fleetwood Town | Sky Bet League One |
| 11 | 28/9/2021 | 10-2 v GillinghamCambridge United 0-2 Gillingham | Sky Bet League One |
| 12 | 2/10/2021 | 12-2 v Crewe AlexandraCrewe Alexandra 2-2 Cambridge United | Sky Bet League One |
| 13 | 16/10/2021 | 12-2 v Ipswich TownCambridge United 2-2 Ipswich Town | Sky Bet League One |
| 14 | 19/10/2021 | 11-1 v Sheffield WednesdayCambridge United 1-1 Sheffield Wednesday | Sky Bet League One |
| 15 | 23/10/2021 | 11-4 v Shrewsbury TownShrewsbury Town 4-1 Cambridge United | Sky Bet League One |
| 16 | 2/11/2021 | 12-0 v MorecambeMorecambe 0-2 Cambridge United | Sky Bet League One |
| 17 | 6/11/2021 | 12-2 v Northampton TownNorthampton Town 2-2 Cambridge United | Emirates FA Cup First Round |
| 18 | 13/11/2021 | 11-4 v Milton Keynes DonsMilton Keynes Dons 4-1 Cambridge United | Sky Bet League One |
| 19 | 16/11/2021 | 13-1 v Northampton TownCambridge United 3-1 Northampton Town | Emirates FA Cup |
| 20 | 20/11/2021 | 11-3 v Rotherham UnitedRotherham United 3-1 Cambridge United | Sky Bet League One |
| 21 | 23/11/2021 | 12-2 v Wigan AthleticCambridge United 2-2 Wigan Athletic | Sky Bet League One |
| 22 | 27/11/2021 | 11-2 v SunderlandCambridge United 1-2 Sunderland | Sky Bet League One |
| 23 | 4/12/2021 | 12-1 v Exeter CityCambridge United 2-1 Exeter City | Emirates FA Cup Second Round |
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