| 1 | 7/8/2021 | 30-0 v Colchester UnitedCarlisle United 0-0 Colchester United | Sky Bet League Two |
| 2 | 14/8/2021 | 32-1 v Swindon TownSwindon Town 1-2 Carlisle United | Sky Bet League Two |
| 3 | 17/8/2021 | 30-0 v Port ValePort Vale 0-0 Carlisle United | Sky Bet League Two |
| 4 | 21/8/2021 | 31-1 v Leyton OrientCarlisle United 1-1 Leyton Orient | Sky Bet League Two |
| 5 | 28/8/2021 | 31-2 v Hartlepool UnitedHartlepool United 2-1 Carlisle United | Sky Bet League Two |
| 6 | 31/8/2021 | 33-3 v Hartlepool UnitedCarlisle United 3-3 Hartlepool United | Checkatrade Trophy |
| 7 | 4/9/2021 | 32-1 v Salford CityCarlisle United 2-1 Salford City | Sky Bet League Two |
| 8 | 11/9/2021 | 3 1-2 v Crawley TownCrawley Town 2-1 Carlisle United | Sky Bet League Two |
| 9 | 18/9/2021 | 32-2 v Scunthorpe UnitedCarlisle United 2-2 Scunthorpe United | Sky Bet League Two |
| 10 | 25/9/2021 | 30-4 v Sutton UnitedSutton United 4-0 Carlisle United | Sky Bet League Two |
| 11 | 2/10/2021 | 30-2 v Forest Green RoversCarlisle United 0-2 Forest Green Rovers | Sky Bet League Two |
| 12 | 9/10/2021 | 3 0-3 v Bristol RoversBristol Rovers 3-0 Carlisle United | Sky Bet League Two |
| 13 | 16/10/2021 | 30-1 v Tranmere RoversCarlisle United 0-1 Tranmere Rovers | Sky Bet League Two |
| 14 | 19/10/2021 | 32-2 v Newport CountyNewport County 2-2 Carlisle United | Sky Bet League Two |
| 15 | 23/10/2021 | 30-0 v Oldham AthleticCarlisle United 0-0 Oldham Athletic | Sky Bet League Two |
| 16 | 30/10/2021 | 3 0-3 v Northampton TownNorthampton Town 3-0 Carlisle United | Sky Bet League Two |
| 17 | 9/11/2021 | 32-0 v MorecambeMorecambe 0-2 Carlisle United | Checkatrade Trophy |
| 18 | 13/11/2021 | 30-0 v BarrowCarlisle United 0-0 Barrow | Sky Bet League Two |
| 19 | 20/11/2021 | 31-2 v Exeter CityExeter City 2-1 Carlisle United | Sky Bet League Two |
| 20 | 27/11/2021 | 3 1-0 v WalsallCarlisle United 1-0 Walsall | Sky Bet League Two |
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