| 1 | 7/8/2021 | 10-0 v Sheffield WednesdayCharlton Athletic 0-0 Sheffield Wednesday | Sky Bet League One |
| 2 | 10/8/2021 | 10-1 v AFC WimbledonCharlton Athletic 0-1 AFC Wimbledon | Carabao Cup First Round |
| 3 | 14/8/2021 | 11-2 v Oxford UnitedOxford United 2-1 Charlton Athletic | Sky Bet League One |
| 4 | 17/8/2021 | 11-2 v Milton Keynes DonsMilton Keynes Dons 2-1 Charlton Athletic | Sky Bet League One |
| 5 | 21/8/2021 | 10-2 v Wigan AthleticCharlton Athletic 0-2 Wigan Athletic | Sky Bet League One |
| 6 | 28/8/2021 | 12-0 v Crewe AlexandraCharlton Athletic 2-0 Crewe Alexandra | Sky Bet League One |
| 7 | 11/9/2021 | 11-2 v Cheltenham TownCharlton Athletic 1-2 Cheltenham Town | Sky Bet League One |
| 8 | 18/9/2021 | 11-2 v Wycombe WanderersWycombe Wanderers 2-1 Charlton Athletic | Sky Bet League One |
| 9 | 21/9/2021 | 11-1 v GillinghamGillingham 1-1 Charlton Athletic | Sky Bet League One |
| 10 | 25/9/2021 | 12-2 v PortsmouthCharlton Athletic 2-2 Portsmouth | Sky Bet League One |
| 11 | 28/9/2021 | 11-4 v Bolton WanderersCharlton Athletic 1-4 Bolton Wanderers | Sky Bet League One |
| 12 | 2/10/2021 | 12-1 v Fleetwood TownFleetwood Town 1-2 Charlton Athletic | Sky Bet League One |
| 13 | 16/10/2021 | 11-2 v Lincoln CityLincoln City 2-1 Charlton Athletic | Sky Bet League One |
| 14 | 19/10/2021 | 12-3 v Accrington StanleyCharlton Athletic 2-3 Accrington Stanley | Sky Bet League One |
| 15 | 23/10/2021 | 11-0 v SunderlandSunderland 0-1 Charlton Athletic | Sky Bet League One |
| 16 | 30/10/2021 | 14-0 v Doncaster RoversCharlton Athletic 4-0 Doncaster Rovers | Sky Bet League One |
| 17 | 2/11/2021 | 11-1 v Rotherham UnitedCharlton Athletic 1-1 Rotherham United | Sky Bet League One |
| 18 | 13/11/2021 | 11-0 v Burton AlbionBurton Albion 0-1 Charlton Athletic | Sky Bet League One |
| 19 | 20/11/2021 | 12-0 v Plymouth ArgyleCharlton Athletic 2-0 Plymouth Argyle | Sky Bet League One |
| 20 | 23/11/2021 | 12-2 v MorecambeMorecambe 2-2 Charlton Athletic | Sky Bet League One |
| 21 | 27/11/2021 | 10-1 v Shrewsbury TownShrewsbury Town 1-0 Charlton Athletic | Sky Bet League One |
| 22 | 7/12/2021 | 12-0 v Ipswich TownCharlton Athletic 2-0 Ipswich Town | Sky Bet League One |
| 23 | 11/12/2021 | 12-0 v Cambridge UnitedCharlton Athletic 2-0 Cambridge United | Sky Bet League One |
| 24 | 18/12/2021 | 10-1 v Plymouth ArgylePlymouth Argyle 1-0 Charlton Athletic | Sky Bet League One |
| 25 | 1/1/2022 | 10-1 v Wycombe WanderersCharlton Athletic 0-1 Wycombe Wanderers | Sky Bet League One |
| 26 | 22/1/2022 | 12-0 v Fleetwood TownCharlton Athletic 2-0 Fleetwood Town | Sky Bet League One |
| 27 | 25/1/2022 | 12-2 v Hartlepool UnitedHartlepool United 2-2 Charlton Athletic | Papa John’s Trophy Quarter Final |
| 28 | 31/1/2022 | 12-1 v PortsmouthPortsmouth 1-2 Charlton Athletic | Sky Bet League One |
| 29 | 5/2/2022 | 13-2 v AFC WimbledonCharlton Athletic 3-2 AFC Wimbledon | Sky Bet League One |
| 30 | 8/2/2022 | 11-2 v Bolton WanderersBolton Wanderers 2-1 Charlton Athletic | Sky Bet League One |
| 31 | 12/2/2022 | 11-2 v Wigan AthleticWigan Athletic 2-1 Charlton Athletic | Sky Bet League One |
| 32 | 19/2/2022 | 10-4 v Oxford UnitedCharlton Athletic 0-4 Oxford United | Sky Bet League One |
| 33 | 22/2/2022 | 10-2 v Milton Keynes DonsCharlton Athletic 0-2 Milton Keynes Dons | Sky Bet League One |
| 34 | 26/2/2022 | 10-2 v Sheffield WednesdaySheffield Wednesday 2-0 Charlton Athletic | Sky Bet League One |
| 35 | 5/3/2022 | 10-0 v SunderlandCharlton Athletic 0-0 Sunderland | Sky Bet League One |
| 36 | 12/3/2022 | 11-2 v Accrington StanleyAccrington Stanley 2-1 Charlton Athletic | Sky Bet League One |
| 37 | 15/3/2022 | 11-0 v GillinghamCharlton Athletic 1-0 Gillingham | Sky Bet League One |
| 38 | 19/3/2022 | 12-0 v Burton AlbionCharlton Athletic 2-0 Burton Albion | Sky Bet League One |
| 39 | 26/3/2022 | 11-0 v Doncaster RoversDoncaster Rovers 0-1 Charlton Athletic | Sky Bet League One |
| 40 | 2/4/2022 | 11-2 v Lincoln CityCharlton Athletic 1-2 Lincoln City | Sky Bet League One |
| 41 | 5/4/2022 | 11-1 v AFC WimbledonAFC Wimbledon 1-1 Charlton Athletic | Sky Bet League One |
| 42 | 9/4/2022 | 11-0 v Rotherham UnitedRotherham United 0-1 Charlton Athletic | Sky Bet League One |
| 43 | 15/4/2022 | 12-3 v MorecambeCharlton Athletic 2-3 Morecambe | Sky Bet League One |
| 44 | 19/4/2022 | 12-0 v Cambridge UnitedCambridge United 0-2 Charlton Athletic | Sky Bet League One |
| 45 | 23/4/2022 | 12-0 v Shrewsbury TownCharlton Athletic 2-0 Shrewsbury Town | Sky Bet League One |
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