| 1 | Sat 14 Aug 2021 | 23-0 v Crystal PalaceChelsea 3-0 Crystal Palace | Premier League |
| 2 | Sun 22 Aug 2021 | 22-0 v ArsenalArsenal 0-2 Chelsea | Premier League |
| 3 | Sat 28 Aug 2021 | 2 1-1 v LiverpoolLiverpool 1-1 Chelsea | Premier League |
| 4 | Sat 11 Sep 2021 | 23-0 v Aston VillaChelsea 3-0 Aston Villa | Premier League |
| 5 | Tue 14 Sep 2021 | 21-0 v Zenit St PetersburgChelsea 1-0 Zenit St Petersburg | UEFA Champions League Group H |
| 6 | Sun 19 Sep 2021 | 23-0 v Tottenham HotspurTottenham Hotspur 0-3 Chelsea | Premier League |
| 7 | Sat 25 Sep 2021 | 2 0-1 v Manchester CityChelsea 0-1 Manchester City | Premier League |
| 8 | Wed 29 Sep 2021 | 2 0-1 v JuventusJuventus 1-0 Chelsea | UEFA Champions League Group H |
| 9 | Sat 2 Oct 2021 | 23-1 v SouthamptonChelsea 3-1 Southampton | Premier League |
| 10 | Wed 20 Oct 2021 | 24-0 v Malmö FFChelsea 4-0 Malmö FF | UEFA Champions League Group H |
| 11 | Sat 23 Oct 2021 | 27-0 v Norwich CityChelsea 7-0 Norwich City | Premier League |
| 12 | Sat 30 Oct 2021 | 23-0 v Newcastle UnitedNewcastle United 0-3 Chelsea | Premier League |
| 13 | Tue 2 Nov 2021 | 21-0 v Malmö FFMalmö FF 0-1 Chelsea | UEFA Champions League Group H |
| 14 | Sat 6 Nov 2021 | 21-1 v BurnleyChelsea 1-1 Burnley | Premier League |
| 15 | Sat 20 Nov 2021 | 23-0 v Leicester CityLeicester City 0-3 Chelsea | Premier League |
| 16 | Tue 23 Nov 2021 | 24-0 v JuventusChelsea 4-0 Juventus | UEFA Champions League Group H |
| 17 | Sun 28 Nov 2021 | 21-1 v Manchester UnitedChelsea 1-1 Manchester United | Premier League |
| 18 | Wed 1 Dec 2021 | 22-1 v WatfordWatford 1-2 Chelsea | Premier League |
| 19 | Sat 4 Dec 2021 | 22-3 v West Ham UnitedWest Ham United 3-2 Chelsea | Premier League |
| 20 | Sat 11 Dec 2021 | 23-2 v Leeds UnitedChelsea 3-2 Leeds United | Premier League |
| 21 | Thu 16 Dec 2021 | 21-1 v EvertonChelsea 1-1 Everton | Premier League |
| 22 | Sun 19 Dec 2021 | 2 0-0 v Wolverhampton WanderersWolverhampton Wanderers 0-0 Chelsea | Premier League |
| 23 | Sun 26 Dec 2021 | 23-1 v Aston VillaAston Villa 1-3 Chelsea | Premier League |
| 24 | Wed 29 Dec 2021 | 2 1-1 v Brighton & Hove AlbionChelsea 1-1 Brighton & Hove Albion | Premier League |
| 25 | Sun 2 Jan 2022 | 22-2 v LiverpoolChelsea 2-2 Liverpool | Premier League |
| 26 | Wed 5 Jan 2022 | 22-0 v Tottenham HotspurChelsea 2-0 Tottenham Hotspur | Carabao Cup Semi Final |
| 27 | Wed 12 Jan 2022 | 21-0 v Tottenham HotspurTottenham Hotspur 0-1 Chelsea | Carabao Cup Semi Final |
| 28 | Sat 15 Jan 2022 | 20-1 v Manchester CityManchester City 1-0 Chelsea | Premier League |
| 29 | Tue 18 Jan 2022 | 2 1-1 v Brighton & Hove AlbionBrighton & Hove Albion 1-1 Chelsea | Premier League |
| 30 | Sun 23 Jan 2022 | 22-0 v Tottenham HotspurChelsea 2-0 Tottenham Hotspur | Premier League |
| 31 | Sat 5 Feb 2022 | 22-1 v Plymouth ArgyleChelsea 2-1 Plymouth Argyle | Emirates FA Cup Fourth Round |
| 32 | Sat 19 Feb 2022 | 21-0 v Crystal PalaceCrystal Palace 0-1 Chelsea | Premier League |
| 33 | Tue 22 Feb 2022 | 22-0 v LilleChelsea 2-0 Lille | UEFA Champions League Round of 16 |
| 34 | Sun 27 Feb 2022 | 20-0 v LiverpoolChelsea 0-0 Liverpool | Carabao Cup Final |
| 35 | Wed 2 Mar 2022 | 23-2 v Luton TownLuton Town 2-3 Chelsea | Emirates FA Cup Fifth Round |
| 36 | Sat 5 Mar 2022 | 24-0 v BurnleyBurnley 0-4 Chelsea | Premier League |
| 37 | Sun 13 Mar 2022 | 2 1-0 v Newcastle UnitedChelsea 1-0 Newcastle United | Premier League |
| 38 | Wed 16 Mar 2022 | 22-1 v LilleLille 1-2 Chelsea | UEFA Champions League Round of 16 |
| 39 | Sat 19 Mar 2022 | 22-0 v MiddlesbroughMiddlesbrough 0-2 Chelsea | Emirates FA Cup Sixth Round |
| 40 | Sat 2 Apr 2022 | 21-4 v BrentfordChelsea 1-4 Brentford | Premier League |
| 41 | Wed 6 Apr 2022 | 2 1-3 v Real MadridChelsea 1-3 Real Madrid | UEFA Champions League Quarter Final |
| 42 | Sat 9 Apr 2022 | 26-0 v SouthamptonSouthampton 0-6 Chelsea | Premier League |
| 43 | Tue 12 Apr 2022 | 23-2 v Real MadridReal Madrid 2-3 Chelsea | UEFA Champions League Quarter Final |
| 44 | Sun 17 Apr 2022 | 22-0 v Crystal PalaceChelsea 2-0 Crystal Palace | Emirates FA Cup Semi Final |
| 45 | Thu 28 Apr 2022 | 2 1-1 v Manchester UnitedManchester United 1-1 Chelsea | Premier League |
| 46 | Sun 1 May 2022 | 2 0-1 v EvertonEverton 1-0 Chelsea | Premier League |
| 47 | Sat 7 May 2022 | 22-2 v Wolverhampton WanderersChelsea 2-2 Wolverhampton Wanderers | Premier League |
| 48 | Wed 11 May 2022 | 23-0 v Leeds UnitedLeeds United 0-3 Chelsea | Premier League |
| 49 | Sat 14 May 2022 | 20-0 v LiverpoolChelsea 0-0 Liverpool | Emirates FA Cup Final |
| 50 | Thu 19 May 2022 | 2 1-1 v Leicester CityChelsea 1-1 Leicester City | Premier League |
| 51 | Sun 22 May 2022 | 22-1 v WatfordChelsea 2-1 Watford | Premier League |
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