| 1 | 7/9/2021 | 220-1 v GillinghamColchester United 0-1 Gillingham | Papa John’s Trophy |
| 2 | 10/9/2021 | 223-2 v BarrowBarrow 2-3 Colchester United | Sky Bet League Two |
| 3 | 16/10/2021 | 221-0 v Harrogate TownColchester United 1-0 Harrogate Town | Sky Bet League Two |
| 4 | 19/10/2021 | 22 1-1 v Bristol RoversColchester United 1-1 Bristol Rovers | Sky Bet League Two |
| 5 | 9/11/2021 | 220-0 v Ipswich TownIpswich Town 0-0 Colchester United | Papa John’s Trophy |
| 6 | 20/11/2021 | 22 0-1 v StevenageStevenage 1-0 Colchester United | Sky Bet League Two |
| 7 | 23/11/2021 | 22 3-1 v Exeter CityColchester United 3-1 Exeter City | Sky Bet League Two |
| 8 | 5/12/2021 | 221-2 v Wigan AthleticColchester United 1-2 Wigan Athletic | Emirates FA Cup Second Round |
| 9 | 8/12/2021 | 220-0 v Bradford CityBradford City 0-0 Colchester United | Sky Bet League Two |
| 10 | 11/12/2021 | 220-3 v WalsallWalsall 3-0 Colchester United | Sky Bet League Two |
| 11 | 1/1/2022 | 221-3 v Crawley TownCrawley Town 3-1 Colchester United | Sky Bet League Two |
| 12 | 4/1/2022 | 221-2 v Sutton UnitedSutton United 2-1 Colchester United | Papa John’s Trophy Third Round |
| 13 | 11/1/2022 | 220-2 v Forest Green RoversForest Green Rovers 2-0 Colchester United | Sky Bet League Two |
| 14 | 15/1/2022 | 220-2 v BarrowColchester United 0-2 Barrow | Sky Bet League Two |
| 15 | 22/1/2022 | 223-0 v Salford CitySalford City 0-3 Colchester United | Sky Bet League Two |
| 16 | 29/1/2022 | 22 1-1 v Swindon TownColchester United 1-1 Swindon Town | Sky Bet League Two |
| 17 | 1/2/2022 | 221-1 v RochdaleColchester United 1-1 Rochdale | Sky Bet League Two |
| 18 | 5/2/2022 | 221-0 v Leyton OrientLeyton Orient 0-1 Colchester United | Sky Bet League Two |
| 19 | 8/2/2022 | 221-2 v Mansfield TownMansfield Town 2-1 Colchester United | Sky Bet League Two |
| 20 | 12/2/2022 | 222-2 v Carlisle UnitedColchester United 2-2 Carlisle United | Sky Bet League Two |
| 21 | 19/2/2022 | 220-3 v Northampton TownNorthampton Town 3-0 Colchester United | Sky Bet League Two |
| 22 | 1/3/2022 | 222-2 v Leyton OrientColchester United 2-2 Leyton Orient | Sky Bet League Two |
| 23 | 5/3/2022 | 221-0 v Port ValeColchester United 1-0 Port Vale | Sky Bet League Two |
| 24 | 21/3/2022 | 220-1 v Forest Green RoversColchester United 0-1 Forest Green Rovers | Sky Bet League Two |
| 25 | 26/3/2022 | 221-0 v Tranmere RoversColchester United 1-0 Tranmere Rovers | Sky Bet League Two |
| 26 | 2/4/2022 | 22 2-1 v Harrogate TownHarrogate Town 1-2 Colchester United | Sky Bet League Two |
| 27 | 18/4/2022 | 223-0 v Bradford CityColchester United 3-0 Bradford City | Sky Bet League Two |
| 28 | 22/4/2022 | 222-1 v Newport CountyNewport County 1-2 Colchester United | Sky Bet League Two |
| 29 | 30/4/2022 | 222-2 v WalsallColchester United 2-2 Walsall | Sky Bet League Two |
| 30 | 7/5/2022 | 222-0 v Hartlepool UnitedHartlepool United 0-2 Colchester United | Sky Bet League Two |
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