| 1 | 14/8/2021 | 70-1 v Northampton TownColchester United 0-1 Northampton Town | Sky Bet League Two |
| 2 | 17/8/2021 | 71-1 v Mansfield TownColchester United 1-1 Mansfield Town | Sky Bet League Two |
| 3 | 21/8/2021 | 72-1 v Oldham AthleticOldham Athletic 1-2 Colchester United | Sky Bet League Two |
| 4 | 27/8/2021 | 71-1 v RochdaleRochdale 1-1 Colchester United | Sky Bet League Two |
| 5 | 7/9/2021 | 70-1 v GillinghamColchester United 0-1 Gillingham | Papa John’s Trophy |
| 6 | 10/9/2021 | 7 3-2 v BarrowBarrow 2-3 Colchester United | Sky Bet League Two |
| 7 | 18/9/2021 | 70-1 v Crawley TownColchester United 0-1 Crawley Town | Sky Bet League Two |
| 8 | 25/9/2021 | 70-0 v Swindon TownSwindon Town 0-0 Colchester United | Sky Bet League Two |
| 9 | 8/10/2021 | 70-2 v Tranmere RoversTranmere Rovers 2-0 Colchester United | Sky Bet League Two |
| 10 | 16/10/2021 | 71-0 v Harrogate TownColchester United 1-0 Harrogate Town | Sky Bet League Two |
| 11 | 19/10/2021 | 71-1 v Bristol RoversColchester United 1-1 Bristol Rovers | Sky Bet League Two |
| 12 | 23/10/2021 | 70-3 v Port ValePort Vale 3-0 Colchester United | Sky Bet League Two |
| 13 | 26/10/2021 | 7 1-3 v Sutton UnitedColchester United 1-3 Sutton United | Sky Bet League Two |
| 14 | 30/10/2021 | 72-1 v Scunthorpe UnitedColchester United 2-1 Scunthorpe United | Sky Bet League Two |
| 15 | 9/11/2021 | 70-0 v Ipswich TownIpswich Town 0-0 Colchester United | Papa John’s Trophy |
| 16 | 23/11/2021 | 73-1 v Exeter CityColchester United 3-1 Exeter City | Sky Bet League Two |
| 17 | 26/11/2021 | 71-1 v Newport CountyColchester United 1-1 Newport County | Sky Bet League Two |
| 18 | 8/12/2021 | 70-0 v Bradford CityBradford City 0-0 Colchester United | Sky Bet League Two |
| 19 | 11/12/2021 | 70-3 v WalsallWalsall 3-0 Colchester United | Sky Bet League Two |
| 20 | 1/1/2022 | 71-3 v Crawley TownCrawley Town 3-1 Colchester United | Sky Bet League Two |
| 21 | 4/1/2022 | 71-2 v Sutton UnitedSutton United 2-1 Colchester United | Papa John’s Trophy Third Round |
| 22 | 11/1/2022 | 70-2 v Forest Green RoversForest Green Rovers 2-0 Colchester United | Sky Bet League Two |
| 23 | 15/1/2022 | 70-2 v BarrowColchester United 0-2 Barrow | Sky Bet League Two |
| 24 | 18/1/2022 | 72-3 v Sutton UnitedSutton United 3-2 Colchester United | Sky Bet League Two |
| 25 | 22/1/2022 | 73-0 v Salford CitySalford City 0-3 Colchester United | Sky Bet League Two |
| 26 | 29/1/2022 | 7 1-1 v Swindon TownColchester United 1-1 Swindon Town | Sky Bet League Two |
| 27 | 5/2/2022 | 71-0 v Leyton OrientLeyton Orient 0-1 Colchester United | Sky Bet League Two |
| 28 | 8/2/2022 | 71-2 v Mansfield TownMansfield Town 2-1 Colchester United | Sky Bet League Two |
| 29 | 26/2/2022 | 71-1 v Oldham AthleticColchester United 1-1 Oldham Athletic | Sky Bet League Two |
| 30 | 1/3/2022 | 72-2 v Leyton OrientColchester United 2-2 Leyton Orient | Sky Bet League Two |
| 31 | 5/3/2022 | 71-0 v Port ValeColchester United 1-0 Port Vale | Sky Bet League Two |
| 32 | 12/3/2022 | 73-1 v Scunthorpe UnitedScunthorpe United 1-3 Colchester United | Sky Bet League Two |
| 33 | 15/3/2022 | 7 0-1 v Bristol RoversBristol Rovers 1-0 Colchester United | Sky Bet League Two |
| 34 | 26/3/2022 | 7 1-0 v Tranmere RoversColchester United 1-0 Tranmere Rovers | Sky Bet League Two |
| 35 | 2/4/2022 | 72-1 v Harrogate TownHarrogate Town 1-2 Colchester United | Sky Bet League Two |
| 36 | 15/4/2022 | 70-2 v Exeter CityExeter City 2-0 Colchester United | Sky Bet League Two |
| 37 | 18/4/2022 | 73-0 v Bradford CityColchester United 3-0 Bradford City | Sky Bet League Two |
| 38 | 22/4/2022 | 72-1 v Newport CountyNewport County 1-2 Colchester United | Sky Bet League Two |
| 39 | 30/4/2022 | 72-2 v WalsallColchester United 2-2 Walsall | Sky Bet League Two |
| 40 | 7/5/2022 | 72-0 v Hartlepool UnitedHartlepool United 0-2 Colchester United | Sky Bet League Two |
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