| 1 | Sat 7 Aug 2021 | 290-0 v Carlisle UnitedCarlisle United 0-0 Colchester United | Sky Bet League Two |
| 2 | Tue 10 Aug 2021 | 290-1 v Birmingham CityBirmingham City 1-0 Colchester United | Carabao Cup First Round |
| 3 | Sat 14 Aug 2021 | 290-1 v Northampton TownColchester United 0-1 Northampton Town | Sky Bet League Two |
| 4 | Tue 17 Aug 2021 | 291-1 v Mansfield TownColchester United 1-1 Mansfield Town | Sky Bet League Two |
| 5 | Sat 21 Aug 2021 | 292-1 v Oldham AthleticOldham Athletic 1-2 Colchester United | Sky Bet League Two |
| 6 | Fri 27 Aug 2021 | 291-1 v RochdaleRochdale 1-1 Colchester United | Sky Bet League Two |
| 7 | Fri 10 Sep 2021 | 293-2 v BarrowBarrow 2-3 Colchester United | Sky Bet League Two |
| 8 | Sat 18 Sep 2021 | 290-1 v Crawley TownColchester United 0-1 Crawley Town | Sky Bet League Two |
| 9 | Sat 25 Sep 2021 | 290-0 v Swindon TownSwindon Town 0-0 Colchester United | Sky Bet League Two |
| 10 | Sat 2 Oct 2021 | 290-2 v Salford CityColchester United 0-2 Salford City | Sky Bet League Two |
| 11 | Fri 8 Oct 2021 | 290-2 v Tranmere RoversTranmere Rovers 2-0 Colchester United | Sky Bet League Two |
| 12 | Sat 16 Oct 2021 | 291-0 v Harrogate TownColchester United 1-0 Harrogate Town | Sky Bet League Two |
| 13 | Tue 19 Oct 2021 | 291-1 v Bristol RoversColchester United 1-1 Bristol Rovers | Sky Bet League Two |
| 14 | Sat 23 Oct 2021 | 290-3 v Port ValePort Vale 3-0 Colchester United | Sky Bet League Two |
| 15 | Tue 26 Oct 2021 | 291-3 v Sutton UnitedColchester United 1-3 Sutton United | Sky Bet League Two |
| 16 | Sat 30 Oct 2021 | 292-1 v Scunthorpe UnitedColchester United 2-1 Scunthorpe United | Sky Bet League Two |
| 17 | Sat 20 Nov 2021 | 29 0-1 v StevenageStevenage 1-0 Colchester United | Sky Bet League Two |
| 18 | Sat 22 Jan 2022 | 293-0 v Salford CitySalford City 0-3 Colchester United | Sky Bet League Two |
| 19 | Sat 29 Jan 2022 | 29 1-1 v Swindon TownColchester United 1-1 Swindon Town | Sky Bet League Two |
| 20 | Sat 26 Feb 2022 | 291-1 v Oldham AthleticColchester United 1-1 Oldham Athletic | Sky Bet League Two |
| 21 | Tue 1 Mar 2022 | 292-2 v Leyton OrientColchester United 2-2 Leyton Orient | Sky Bet League Two |
| 22 | Sat 5 Mar 2022 | 291-0 v Port ValeColchester United 1-0 Port Vale | Sky Bet League Two |
| 23 | Sat 12 Mar 2022 | 293-1 v Scunthorpe UnitedScunthorpe United 1-3 Colchester United | Sky Bet League Two |
| 24 | Tue 15 Mar 2022 | 290-1 v Bristol RoversBristol Rovers 1-0 Colchester United | Sky Bet League Two |
| 25 | Mon 21 Mar 2022 | 290-1 v Forest Green RoversColchester United 0-1 Forest Green Rovers | Sky Bet League Two |
| 26 | Sat 26 Mar 2022 | 291-0 v Tranmere RoversColchester United 1-0 Tranmere Rovers | Sky Bet League Two |
| 27 | Sat 2 Apr 2022 | 292-1 v Harrogate TownHarrogate Town 1-2 Colchester United | Sky Bet League Two |
| 28 | Sat 9 Apr 2022 | 290-2 v StevenageColchester United 0-2 Stevenage | Sky Bet League Two |
| 29 | Fri 15 Apr 2022 | 290-2 v Exeter CityExeter City 2-0 Colchester United | Sky Bet League Two |
| 30 | Mon 18 Apr 2022 | 293-0 v Bradford CityColchester United 3-0 Bradford City | Sky Bet League Two |
| 31 | Fri 22 Apr 2022 | 29 2-1 v Newport CountyNewport County 1-2 Colchester United | Sky Bet League Two |
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