| 1 | Sat 7 Aug 2021 | 50-0 v Carlisle UnitedCarlisle United 0-0 Colchester United | Sky Bet League Two |
| 2 | Tue 10 Aug 2021 | 50-1 v Birmingham CityBirmingham City 1-0 Colchester United | Carabao Cup First Round |
| 3 | Sat 14 Aug 2021 | 50-1 v Northampton TownColchester United 0-1 Northampton Town | Sky Bet League Two |
| 4 | Sat 21 Aug 2021 | 52-1 v Oldham AthleticOldham Athletic 1-2 Colchester United | Sky Bet League Two |
| 5 | Fri 27 Aug 2021 | 51-1 v RochdaleRochdale 1-1 Colchester United | Sky Bet League Two |
| 6 | Fri 10 Sep 2021 | 53-2 v BarrowBarrow 2-3 Colchester United | Sky Bet League Two |
| 7 | Sat 18 Sep 2021 | 50-1 v Crawley TownColchester United 0-1 Crawley Town | Sky Bet League Two |
| 8 | Sat 25 Sep 2021 | 50-0 v Swindon TownSwindon Town 0-0 Colchester United | Sky Bet League Two |
| 9 | Sat 2 Oct 2021 | 50-2 v Salford CityColchester United 0-2 Salford City | Sky Bet League Two |
| 10 | Sat 16 Oct 2021 | 51-0 v Harrogate TownColchester United 1-0 Harrogate Town | Sky Bet League Two |
| 11 | Sat 23 Oct 2021 | 50-3 v Port ValePort Vale 3-0 Colchester United | Sky Bet League Two |
| 12 | Tue 26 Oct 2021 | 5 1-3 v Sutton UnitedColchester United 1-3 Sutton United | Sky Bet League Two |
| 13 | Sat 20 Nov 2021 | 50-1 v StevenageStevenage 1-0 Colchester United | Sky Bet League Two |
| 14 | Tue 23 Nov 2021 | 53-1 v Exeter CityColchester United 3-1 Exeter City | Sky Bet League Two |
| 15 | Fri 26 Nov 2021 | 51-1 v Newport CountyColchester United 1-1 Newport County | Sky Bet League Two |
| 16 | Sun 5 Dec 2021 | 51-2 v Wigan AthleticColchester United 1-2 Wigan Athletic | Emirates FA Cup Second Round |
| 17 | Wed 8 Dec 2021 | 5 0-0 v Bradford CityBradford City 0-0 Colchester United | Sky Bet League Two |
| 18 | Sat 11 Dec 2021 | 50-3 v WalsallWalsall 3-0 Colchester United | Sky Bet League Two |
| 19 | Sat 1 Jan 2022 | 51-3 v Crawley TownCrawley Town 3-1 Colchester United | Sky Bet League Two |
| 20 | Tue 4 Jan 2022 | 51-2 v Sutton UnitedSutton United 2-1 Colchester United | Papa John’s Trophy Third Round |
| 21 | Tue 11 Jan 2022 | 50-2 v Forest Green RoversForest Green Rovers 2-0 Colchester United | Sky Bet League Two |
| 22 | Tue 18 Jan 2022 | 5 2-3 v Sutton UnitedSutton United 3-2 Colchester United | Sky Bet League Two |
| 23 | Sat 5 Feb 2022 | 51-0 v Leyton OrientLeyton Orient 0-1 Colchester United | Sky Bet League Two |
| 24 | Tue 8 Feb 2022 | 51-2 v Mansfield TownMansfield Town 2-1 Colchester United | Sky Bet League Two |
| 25 | Sat 12 Feb 2022 | 52-2 v Carlisle UnitedColchester United 2-2 Carlisle United | Sky Bet League Two |
| 26 | Sat 19 Feb 2022 | 50-3 v Northampton TownNorthampton Town 3-0 Colchester United | Sky Bet League Two |
| 27 | Tue 22 Feb 2022 | 51-2 v Hartlepool UnitedColchester United 1-2 Hartlepool United | Sky Bet League Two |
| 28 | Sat 26 Feb 2022 | 51-1 v Oldham AthleticColchester United 1-1 Oldham Athletic | Sky Bet League Two |
| 29 | Sat 5 Mar 2022 | 51-0 v Port ValeColchester United 1-0 Port Vale | Sky Bet League Two |
| 30 | Sat 12 Mar 2022 | 53-1 v Scunthorpe UnitedScunthorpe United 1-3 Colchester United | Sky Bet League Two |
| 31 | Fri 15 Apr 2022 | 50-2 v Exeter CityExeter City 2-0 Colchester United | Sky Bet League Two |
| 32 | Mon 18 Apr 2022 | 53-0 v Bradford CityColchester United 3-0 Bradford City | Sky Bet League Two |
| 33 | Fri 22 Apr 2022 | 52-1 v Newport CountyNewport County 1-2 Colchester United | Sky Bet League Two |
| 34 | Sat 30 Apr 2022 | 52-2 v WalsallColchester United 2-2 Walsall | Sky Bet League Two |
| 35 | Sat 7 May 2022 | 5 2-0 v Hartlepool UnitedHartlepool United 0-2 Colchester United | Sky Bet League Two |
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