| 1 | 7/8/2021 | 220-0 v Carlisle UnitedCarlisle United 0-0 Colchester United | Sky Bet League Two |
| 2 | 10/8/2021 | 220-1 v Birmingham CityBirmingham City 1-0 Colchester United | Carabao Cup First Round |
| 3 | 14/8/2021 | 220-1 v Northampton TownColchester United 0-1 Northampton Town | Sky Bet League Two |
| 4 | 21/8/2021 | 222-1 v Oldham AthleticOldham Athletic 1-2 Colchester United | Sky Bet League Two |
| 5 | 7/9/2021 | 220-1 v GillinghamColchester United 0-1 Gillingham | Checkatrade Trophy |
| 6 | 10/9/2021 | 223-2 v BarrowBarrow 2-3 Colchester United | Sky Bet League Two |
| 7 | 18/9/2021 | 220-1 v Crawley TownColchester United 0-1 Crawley Town | Sky Bet League Two |
| 8 | 8/10/2021 | 220-2 v Tranmere RoversTranmere Rovers 2-0 Colchester United | Sky Bet League Two |
| 9 | 16/10/2021 | 221-0 v Harrogate TownColchester United 1-0 Harrogate Town | Sky Bet League Two |
| 10 | 19/10/2021 | 22 1-1 v Bristol RoversColchester United 1-1 Bristol Rovers | Sky Bet League Two |
| 11 | 9/11/2021 | 220-0 v Ipswich TownIpswich Town 0-0 Colchester United | Checkatrade Trophy |
| 12 | 20/11/2021 | 22 0-1 v StevenageStevenage 1-0 Colchester United | Sky Bet League Two |
| 13 | 23/11/2021 | 22 3-1 v Exeter CityColchester United 3-1 Exeter City | Sky Bet League Two |
| 14 | 26/11/2021 | 221-1 v Newport CountyColchester United 1-1 Newport County | Sky Bet League Two |
| 15 | 5/12/2021 | 221-2 v Wigan AthleticColchester United 1-2 Wigan Athletic | Emirates FA Cup Second Round |
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