| 1 | Fri 12 Nov 2021 | 280-2 v Bolton WanderersBolton Wanderers 2-0 Crewe Alexandra | Sky Bet League One |
| 2 | Sat 20 Nov 2021 | 282-0 v GillinghamCrewe Alexandra 2-0 Gillingham | Sky Bet League One |
| 3 | Tue 23 Nov 2021 | 28 2-3 v AFC WimbledonAFC Wimbledon 3-2 Crewe Alexandra | Sky Bet League One |
| 4 | Sun 28 Nov 2021 | 28 1-2 v Ipswich TownIpswich Town 2-1 Crewe Alexandra | Sky Bet League One |
| 5 | Tue 7 Dec 2021 | 282-0 v Lincoln CityCrewe Alexandra 2-0 Lincoln City | Sky Bet League One |
| 6 | Sat 11 Dec 2021 | 280-2 v Sheffield WednesdayCrewe Alexandra 0-2 Sheffield Wednesday | Sky Bet League One |
| 7 | Wed 29 Dec 2021 | 282-1 v MorecambeMorecambe 1-2 Crewe Alexandra | Sky Bet League One |
| 8 | Sat 1 Jan 2022 | 281-4 v Burton AlbionBurton Albion 4-1 Crewe Alexandra | Sky Bet League One |
| 9 | Wed 12 Jan 2022 | 282-1 v Charlton AthleticCrewe Alexandra 2-1 Charlton Athletic | Sky Bet League One |
| 10 | Sat 22 Jan 2022 | 280-1 v Cambridge UnitedCambridge United 1-0 Crewe Alexandra | Sky Bet League One |
| 11 | Tue 8 Mar 2022 | 281-3 v PortsmouthCrewe Alexandra 1-3 Portsmouth | Sky Bet League One |
| 12 | Sat 12 Mar 2022 | 28 0-2 v SunderlandSunderland 2-0 Crewe Alexandra | Sky Bet League One |
| 13 | Tue 15 Mar 2022 | 28 0-2 v Wigan AthleticCrewe Alexandra 0-2 Wigan Athletic | Sky Bet League One |
| 14 | Sat 19 Mar 2022 | 280-1 v Bolton WanderersCrewe Alexandra 0-1 Bolton Wanderers | Sky Bet League One |
| 15 | Sat 2 Apr 2022 | 281-3 v Fleetwood TownCrewe Alexandra 1-3 Fleetwood Town | Sky Bet League One |
| 16 | Tue 5 Apr 2022 | 281-2 v Milton Keynes DonsMilton Keynes Dons 2-1 Crewe Alexandra | Sky Bet League One |
| 17 | Sat 9 Apr 2022 | 280-2 v Doncaster RoversDoncaster Rovers 2-0 Crewe Alexandra | Sky Bet League One |
| 18 | Fri 15 Apr 2022 | 283-1 v AFC WimbledonCrewe Alexandra 3-1 AFC Wimbledon | Sky Bet League One |
| 19 | Tue 19 Apr 2022 | 28 0-1 v Sheffield WednesdaySheffield Wednesday 1-0 Crewe Alexandra | Sky Bet League One |
| 20 | Sat 23 Apr 2022 | 281-1 v Ipswich TownCrewe Alexandra 1-1 Ipswich Town | Sky Bet League One |
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