| 1 | 7/8/2021 | 311-1 v Cheltenham TownCrewe Alexandra 1-1 Cheltenham Town | Sky Bet League One |
| 2 | 14/8/2021 | 310-2 v PortsmouthPortsmouth 2-0 Crewe Alexandra | Sky Bet League One |
| 3 | 17/8/2021 | 310-1 v Oxford UnitedOxford United 1-0 Crewe Alexandra | Sky Bet League One |
| 4 | 21/8/2021 | 310-1 v Accrington StanleyCrewe Alexandra 0-1 Accrington Stanley | Sky Bet League One |
| 5 | 24/8/2021 | 310-3 v Leeds UnitedLeeds United 3-0 Crewe Alexandra | Carabao Cup Second Round |
| 6 | 28/8/2021 | 310-2 v Charlton AthleticCharlton Athletic 2-0 Crewe Alexandra | Sky Bet League One |
| 7 | 31/8/2021 | 311-0 v Shrewsbury TownShrewsbury Town 0-1 Crewe Alexandra | Checkatrade Trophy |
| 8 | 11/9/2021 | 311-1 v Shrewsbury TownShrewsbury Town 1-1 Crewe Alexandra | Sky Bet League One |
| 9 | 18/9/2021 | 312-0 v Burton AlbionCrewe Alexandra 2-0 Burton Albion | Sky Bet League One |
| 10 | 21/9/2021 | 311-3 v MorecambeCrewe Alexandra 1-3 Morecambe | Sky Bet League One |
| 11 | 25/9/2021 | 311-1 v Rotherham UnitedRotherham United 1-1 Crewe Alexandra | Sky Bet League One |
| 12 | 28/9/2021 | 311-1 v Plymouth ArgylePlymouth Argyle 1-1 Crewe Alexandra | Sky Bet League One |
| 13 | 2/10/2021 | 312-2 v Cambridge UnitedCrewe Alexandra 2-2 Cambridge United | Sky Bet League One |
| 14 | 5/10/2021 | 312-0 v Wigan AthleticCrewe Alexandra 2-0 Wigan Athletic | Checkatrade Trophy |
| 15 | 16/10/2021 | 310-3 v Fleetwood TownFleetwood Town 3-0 Crewe Alexandra | Sky Bet League One |
| 16 | 19/10/2021 | 310-4 v SunderlandCrewe Alexandra 0-4 Sunderland | Sky Bet League One |
| 17 | 23/10/2021 | 311-2 v Wycombe WanderersWycombe Wanderers 2-1 Crewe Alexandra | Sky Bet League One |
| 18 | 30/10/2021 | 311-4 v Milton Keynes DonsCrewe Alexandra 1-4 Milton Keynes Dons | Sky Bet League One |
| 19 | 2/11/2021 | 311-1 v Doncaster RoversCrewe Alexandra 1-1 Doncaster Rovers | Sky Bet League One |
| 20 | 6/11/2021 | 310-3 v Swindon TownCrewe Alexandra 0-3 Swindon Town | Emirates FA Cup First Round |
| 21 | 12/11/2021 | 310-2 v Bolton WanderersBolton Wanderers 2-0 Crewe Alexandra | Sky Bet League One |
| 22 | 20/11/2021 | 312-0 v GillinghamCrewe Alexandra 2-0 Gillingham | Sky Bet League One |
| 23 | 23/11/2021 | 312-3 v AFC WimbledonAFC Wimbledon 3-2 Crewe Alexandra | Sky Bet League One |
| 24 | 28/11/2021 | 311-2 v Ipswich TownIpswich Town 2-1 Crewe Alexandra | Sky Bet League One |
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