| 1 | Sat 14 Aug 2021 | 70-3 v CheshuntCheshunt 3-0 East Thurrock United | Isthmian League - Premier Division |
| 2 | Sat 21 Aug 2021 | 72-2 v Bognor Regis TownEast Thurrock United 2-2 Bognor Regis Town | Isthmian League - Premier Division |
| 3 | Sat 4 Sep 2021 | 73-1 v Cambridge CityCambridge City 1-3 East Thurrock United | Emirates FA Cup First Qualifying Round |
| 4 | Sat 11 Sep 2021 | 72-3 v WorthingWorthing 3-2 East Thurrock United | Isthmian League - Premier Division |
| 5 | Tue 14 Sep 2021 | 71-1 v Folkestone InvictaEast Thurrock United 1-1 Folkestone Invicta | Isthmian League - Premier Division |
| 6 | Sat 18 Sep 2021 | 72-2 v Needham MarketEast Thurrock United 2-2 Needham Market | Emirates FA Cup Second Qualifying Round |
| 7 | Tue 21 Sep 2021 | 73-2 v Needham MarketNeedham Market 2-3 East Thurrock United | Emirates FA Cup Second Qualifying Round Replay |
| 8 | Sat 25 Sep 2021 | 71-5 v Haringey BoroughHaringey Borough 5-1 East Thurrock United | Isthmian League - Premier Division |
| 9 | Sat 2 Oct 2021 | 70-4 v Boston UnitedBoston United 4-0 East Thurrock United | Emirates FA Cup Third Qualifying Round |
| 10 | Tue 12 Oct 2021 | 70-3 v Potters Bar TownPotters Bar Town 3-0 East Thurrock United | Isthmian League - Premier Division |
| 11 | Sat 16 Oct 2021 | 71-4 v Carshalton AthleticCarshalton Athletic 4-1 East Thurrock United | Isthmian League - Premier Division |
| 12 | Tue 19 Oct 2021 | 71-2 v Bishop's StortfordEast Thurrock United 1-2 Bishop's Stortford | Isthmian League - Premier Division |
| 13 | Sat 23 Oct 2021 | 70-8 v Enfield TownEast Thurrock United 0-8 Enfield Town | Isthmian League - Premier Division |
| 14 | Tue 26 Oct 2021 | 70-2 v MargateMargate 2-0 East Thurrock United | Isthmian League - Premier Division |
| 15 | Sat 30 Oct 2021 | 70-6 v KingstonianEast Thurrock United 0-6 Kingstonian | Buildbase FA Trophy Third Qualifying Round |
| 16 | Sat 6 Nov 2021 | 70-2 v LeatherheadEast Thurrock United 0-2 Leatherhead | Isthmian League - Premier Division |
| 17 | Tue 9 Nov 2021 | 72-0 v LewesEast Thurrock United 2-0 Lewes | Isthmian League - Premier Division |
| 18 | Sat 20 Nov 2021 | 71-1 v Corinthian-CasualsEast Thurrock United 1-1 Corinthian-Casuals | Isthmian League - Premier Division |
| 19 | Sat 27 Nov 2021 | 7 2-2 v MersthamMerstham 2-2 East Thurrock United | Isthmian League - Premier Division |
| 20 | Sat 4 Dec 2021 | 70-2 v Bowers & PitseaEast Thurrock United 0-2 Bowers & Pitsea | Isthmian League - Premier Division |
| 21 | Tue 7 Dec 2021 | 72-1 v Brightlingsea RegentBrightlingsea Regent 1-2 East Thurrock United | Essex County Cup Third Round |
| 22 | Sat 11 Dec 2021 | 71-3 v HorshamHorsham 3-1 East Thurrock United | Isthmian League - Premier Division |
| 23 | Wed 15 Dec 2021 | 71-0 v KingstonianKingstonian 0-1 East Thurrock United | Isthmian League - Premier Division |
| 24 | Mon 27 Dec 2021 | 71-2 v Brightlingsea RegentBrightlingsea Regent 2-1 East Thurrock United | Isthmian League - Premier Division |
| 25 | Sat 1 Jan 2022 | 71-3 v Cray WanderersEast Thurrock United 1-3 Cray Wanderers | Isthmian League - Premier Division |
| 26 | Mon 3 Jan 2022 | 70-5 v Wingate & FinchleyWingate & Finchley 5-0 East Thurrock United | Isthmian League - Premier Division |
| 27 | Sat 22 Jan 2022 | 81-4 v Bishop's StortfordBishop's Stortford 4-1 East Thurrock United | Isthmian League - Premier Division |
| 28 | Wed 26 Jan 2022 | 77-0 v RomfordRomford 0-7 East Thurrock United | Velocity Trophy Third Round |
| 29 | Sat 29 Jan 2022 | 101-3 v Haringey BoroughEast Thurrock United 1-3 Haringey Borough | Isthmian League - Premier Division |
| 30 | Sat 5 Feb 2022 | 72-3 v LewesLewes 3-2 East Thurrock United | Isthmian League - Premier Division |
| 31 | Sat 12 Feb 2022 | 70-0 v MargateEast Thurrock United 0-0 Margate | Isthmian League - Premier Division |
| 32 | Sat 19 Feb 2022 | 70-6 v HornchurchHornchurch 6-0 East Thurrock United | Isthmian League - Premier Division |
| 33 | Tue 22 Feb 2022 | 71-1 v BarkingBarking 1-1 East Thurrock United | Velocity Trophy Fourth Round |
| 34 | Sat 26 Feb 2022 | 71-0 v Carshalton AthleticEast Thurrock United 1-0 Carshalton Athletic | Isthmian League - Premier Division |
| 35 | Tue 1 Mar 2022 | 71-3 v Folkestone InvictaFolkestone Invicta 3-1 East Thurrock United | Isthmian League - Premier Division |
| 36 | Sat 5 Mar 2022 | 70-3 v Enfield TownEnfield Town 3-0 East Thurrock United | Isthmian League - Premier Division |
| 37 | Tue 8 Mar 2022 | 70-1 v WorthingEast Thurrock United 0-1 Worthing | Isthmian League - Premier Division |
| 38 | Sat 12 Mar 2022 | 72-1 v KingstonianEast Thurrock United 2-1 Kingstonian | Isthmian League - Premier Division |
| 39 | Sat 19 Mar 2022 | 71-3 v LeatherheadLeatherhead 3-1 East Thurrock United | Isthmian League - Premier Division |
| 40 | Sat 26 Mar 2022 | 72-1 v Corinthian-CasualsCorinthian-Casuals 1-2 East Thurrock United | Isthmian League - Premier Division |
| 41 | Tue 29 Mar 2022 | 7 1-0 v Potters Bar TownEast Thurrock United 1-0 Potters Bar Town | Isthmian League - Premier Division |
| 42 | Sat 2 Apr 2022 | 72-0 v MersthamEast Thurrock United 2-0 Merstham | Isthmian League - Premier Division |
| 43 | Sat 9 Apr 2022 | 71-1 v Bognor Regis TownBognor Regis Town 1-1 East Thurrock United | Isthmian League - Premier Division |
| 44 | Sat 16 Apr 2022 | 72-2 v Wingate & FinchleyEast Thurrock United 2-2 Wingate & Finchley | Isthmian League - Premier Division |
| 45 | Wed 20 Apr 2022 | 71-4 v Cray WanderersCray Wanderers 4-1 East Thurrock United | Isthmian League - Premier Division |
| 46 | Sat 23 Apr 2022 | 72-3 v HorshamEast Thurrock United 2-3 Horsham | Isthmian League - Premier Division |
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