| 1 | Sat 22 Jan 2022 | 21-4 v Bishop's StortfordBishop's Stortford 4-1 East Thurrock United | Isthmian League - Premier Division |
| 2 | Sat 29 Jan 2022 | 21-3 v Haringey BoroughEast Thurrock United 1-3 Haringey Borough | Isthmian League - Premier Division |
| 3 | Sat 5 Feb 2022 | 22-3 v LewesLewes 3-2 East Thurrock United | Isthmian League - Premier Division |
| 4 | Sat 12 Feb 2022 | 20-0 v MargateEast Thurrock United 0-0 Margate | Isthmian League - Premier Division |
| 5 | Sat 19 Feb 2022 | 20-6 v HornchurchHornchurch 6-0 East Thurrock United | Isthmian League - Premier Division |
| 6 | Sat 26 Feb 2022 | 21-0 v Carshalton AthleticEast Thurrock United 1-0 Carshalton Athletic | Isthmian League - Premier Division |
| 7 | Tue 1 Mar 2022 | 21-3 v Folkestone InvictaFolkestone Invicta 3-1 East Thurrock United | Isthmian League - Premier Division |
| 8 | Sat 5 Mar 2022 | 20-3 v Enfield TownEnfield Town 3-0 East Thurrock United | Isthmian League - Premier Division |
| 9 | Tue 8 Mar 2022 | 20-1 v WorthingEast Thurrock United 0-1 Worthing | Isthmian League - Premier Division |
| 10 | Sat 12 Mar 2022 | 52-1 v KingstonianEast Thurrock United 2-1 Kingstonian | Isthmian League - Premier Division |
| 11 | Sat 19 Mar 2022 | 5 1-3 v LeatherheadLeatherhead 3-1 East Thurrock United | Isthmian League - Premier Division |
| 12 | Tue 22 Mar 2022 | 50-2 v CheshuntEast Thurrock United 0-2 Cheshunt | Isthmian League - Premier Division |
| 13 | Sat 26 Mar 2022 | 62-1 v Corinthian-CasualsCorinthian-Casuals 1-2 East Thurrock United | Isthmian League - Premier Division |
| 14 | Tue 29 Mar 2022 | 5 1-0 v Potters Bar TownEast Thurrock United 1-0 Potters Bar Town | Isthmian League - Premier Division |
| 15 | Sat 2 Apr 2022 | 52-0 v MersthamEast Thurrock United 2-0 Merstham | Isthmian League - Premier Division |
| 16 | Sat 9 Apr 2022 | 51-1 v Bognor Regis TownBognor Regis Town 1-1 East Thurrock United | Isthmian League - Premier Division |
| 17 | Sat 16 Apr 2022 | 52-2 v Wingate & FinchleyEast Thurrock United 2-2 Wingate & Finchley | Isthmian League - Premier Division |
| 18 | Wed 20 Apr 2022 | 51-4 v Cray WanderersCray Wanderers 4-1 East Thurrock United | Isthmian League - Premier Division |
| 19 | Sat 23 Apr 2022 | 52-3 v HorshamEast Thurrock United 2-3 Horsham | Isthmian League - Premier Division |
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