| 1 | Sat 23 Oct 2021 | 252-2 v ElcheElche 2-2 Espanyol | Spanish La Liga |
| 2 | Tue 26 Oct 2021 | 25 1-1 v Athletic BilbaoEspanyol 1-1 Athletic Bilbao | Spanish La Liga |
| 3 | Sun 31 Oct 2021 | 251-2 v GetafeGetafe 2-1 Espanyol | Spanish La Liga |
| 4 | Sat 6 Nov 2021 | 252-0 v GranadaEspanyol 2-0 Granada | Spanish La Liga |
| 5 | Sat 20 Nov 2021 | 250-1 v BarcelonaBarcelona 1-0 Espanyol | Spanish La Liga |
| 6 | Sun 28 Nov 2021 | 251-0 v Real SociedadEspanyol 1-0 Real Sociedad | Spanish La Liga |
| 7 | Sun 5 Dec 2021 | 250-1 v Rayo VallecanoRayo Vallecano 1-0 Espanyol | Spanish La Liga |
| 8 | Sat 11 Dec 2021 | 25 4-3 v LevanteEspanyol 4-3 Levante | Spanish La Liga |
| 9 | Fri 17 Dec 2021 | 251-3 v Celta VigoCelta Vigo 3-1 Espanyol | Spanish La Liga |
| 10 | Mon 7 Feb 2022 | 251-2 v Athletic BilbaoAthletic Bilbao 2-1 Espanyol | Spanish La Liga |
| 11 | Sun 13 Feb 2022 | 252-2 v BarcelonaEspanyol 2-2 Barcelona | Spanish La Liga |
| 12 | Sun 20 Feb 2022 | 251-1 v SevillaEspanyol 1-1 Sevilla | Spanish La Liga |
| 13 | Sun 27 Feb 2022 | 251-5 v VillarrealVillarreal 5-1 Espanyol | Spanish La Liga |
| 14 | Sat 5 Mar 2022 | 25 2-0 v GetafeEspanyol 2-0 Getafe | Spanish La Liga |
| 15 | Sat 12 Mar 2022 | 251-1 v LevanteLevante 1-1 Espanyol | Spanish La Liga |
| 16 | Sun 20 Mar 2022 | 251-0 v MallorcaEspanyol 1-0 Mallorca | Spanish La Liga |
| 17 | Mon 4 Apr 2022 | 25 0-1 v Real SociedadReal Sociedad 1-0 Espanyol | Spanish La Liga |
| 18 | Sun 10 Apr 2022 | 25 1-0 v Celta VigoEspanyol 1-0 Celta Vigo | Spanish La Liga |
| 19 | Thu 21 Apr 2022 | 250-1 v Rayo VallecanoEspanyol 0-1 Rayo Vallecano | Spanish La Liga |
| 20 | Sat 30 Apr 2022 | 250-4 v Real MadridReal Madrid 4-0 Espanyol | Spanish La Liga |
| 21 | Sun 8 May 2022 | 251-1 v OsasunaEspanyol 1-1 Osasuna | Spanish La Liga |
| 22 | Wed 11 May 2022 | 25 1-2 v AlavésAlavés 2-1 Espanyol | Spanish La Liga |
| 23 | Sun 22 May 2022 | 250-0 v GranadaGranada 0-0 Espanyol | Spanish La Liga |
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