| 1 | Fri 18 Sep 2020 | 250-8 v Bayern MunichBayern Munich 8-0 FC Schalke 04 | German Bundesliga |
| 2 | Sun 18 Oct 2020 | 25 1-1 v 1. FC Union BerlinFC Schalke 04 1-1 1. FC Union Berlin | German Bundesliga |
| 3 | Sat 24 Oct 2020 | 250-3 v Borussia DortmundBorussia Dortmund 3-0 FC Schalke 04 | German Bundesliga |
| 4 | Fri 30 Oct 2020 | 251-1 v VfB StuttgartFC Schalke 04 1-1 VfB Stuttgart | German Bundesliga |
| 5 | Sat 7 Nov 2020 | 252-2 v Mainz 05Mainz 05 2-2 FC Schalke 04 | German Bundesliga |
| 6 | Sat 21 Nov 2020 | 250-2 v VfL WolfsburgFC Schalke 04 0-2 VfL Wolfsburg | German Bundesliga |
| 7 | Wed 16 Dec 2020 | 250-2 v SC FreiburgFC Schalke 04 0-2 SC Freiburg | German Bundesliga |
| 8 | Sat 19 Dec 2020 | 25 0-1 v Arminia BielefeldFC Schalke 04 0-1 Arminia Bielefeld | German Bundesliga |
| 9 | Sat 2 Jan 2021 | 250-3 v Hertha BerlinHertha Berlin 3-0 FC Schalke 04 | German Bundesliga |
| 10 | Sat 9 Jan 2021 | 254-0 v 1899 HoffenheimFC Schalke 04 4-0 1899 Hoffenheim | German Bundesliga |
| 11 | Sun 17 Jan 2021 | 251-3 v Eintracht FrankfurtEintracht Frankfurt 3-1 FC Schalke 04 | German Bundesliga |
| 12 | Wed 20 Jan 2021 | 251-2 v 1. FC KölnFC Schalke 04 1-2 1. FC Köln | German Bundesliga |
| 13 | Sun 24 Jan 2021 | 250-4 v Bayern MunichFC Schalke 04 0-4 Bayern Munich | German Bundesliga |
| 14 | Sat 30 Jan 2021 | 251-1 v Werder BremenWerder Bremen 1-1 FC Schalke 04 | German Bundesliga |
| 15 | Sat 6 Feb 2021 | 250-3 v RB LeipzigFC Schalke 04 0-3 RB Leipzig | German Bundesliga |
| 16 | Sat 13 Feb 2021 | 25 0-0 v 1. FC Union Berlin1. FC Union Berlin 0-0 FC Schalke 04 | German Bundesliga |
| 17 | Sat 20 Feb 2021 | 250-4 v Borussia DortmundFC Schalke 04 0-4 Borussia Dortmund | German Bundesliga |
| 18 | Sat 27 Feb 2021 | 251-5 v VfB StuttgartVfB Stuttgart 5-1 FC Schalke 04 | German Bundesliga |
| 19 | Fri 5 Mar 2021 | 250-0 v Mainz 05FC Schalke 04 0-0 Mainz 05 | German Bundesliga |
| 20 | Sat 13 Mar 2021 | 250-5 v VfL WolfsburgVfL Wolfsburg 5-0 FC Schalke 04 | German Bundesliga |
| 21 | Sat 20 Mar 2021 | 250-3 v Borussia MönchengladbachFC Schalke 04 0-3 Borussia Mönchengladbach | German Bundesliga |
| 22 | Sat 3 Apr 2021 | 251-2 v Bayer 04 LeverkusenBayer 04 Leverkusen 2-1 FC Schalke 04 | German Bundesliga |
| 23 | Sun 11 Apr 2021 | 251-0 v FC AugsburgFC Schalke 04 1-0 FC Augsburg | German Bundesliga |
| 24 | Sat 17 Apr 2021 | 250-4 v SC FreiburgSC Freiburg 4-0 FC Schalke 04 | German Bundesliga |
| 25 | Tue 20 Apr 2021 | 250-1 v Arminia BielefeldArminia Bielefeld 1-0 FC Schalke 04 | German Bundesliga |
| 26 | Sat 8 May 2021 | 252-4 v 1899 Hoffenheim1899 Hoffenheim 4-2 FC Schalke 04 | German Bundesliga |
| 27 | Wed 12 May 2021 | 25 1-2 v Hertha BerlinFC Schalke 04 1-2 Hertha Berlin | German Bundesliga |
| 28 | Sat 15 May 2021 | 254-3 v Eintracht FrankfurtFC Schalke 04 4-3 Eintracht Frankfurt | German Bundesliga |
| 29 | Sat 22 May 2021 | 250-1 v 1. FC Köln1. FC Köln 1-0 FC Schalke 04 | German Bundesliga |
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