| 1 | Sat 3 Oct 2020 | 5 0-4 v RB LeipzigRB Leipzig 4-0 FC Schalke 04 | German Bundesliga |
| 2 | Sun 18 Oct 2020 | 51-1 v 1. FC Union BerlinFC Schalke 04 1-1 1. FC Union Berlin | German Bundesliga |
| 3 | Sat 24 Oct 2020 | 50-3 v Borussia DortmundBorussia Dortmund 3-0 FC Schalke 04 | German Bundesliga |
| 4 | Fri 30 Oct 2020 | 51-1 v VfB StuttgartFC Schalke 04 1-1 VfB Stuttgart | German Bundesliga |
| 5 | Sat 7 Nov 2020 | 52-2 v Mainz 05Mainz 05 2-2 FC Schalke 04 | German Bundesliga |
| 6 | Sat 21 Nov 2020 | 50-2 v VfL WolfsburgFC Schalke 04 0-2 VfL Wolfsburg | German Bundesliga |
| 7 | Sat 28 Nov 2020 | 51-4 v Borussia MönchengladbachBorussia Mönchengladbach 4-1 FC Schalke 04 | German Bundesliga |
| 8 | Sun 13 Dec 2020 | 52-2 v FC AugsburgFC Augsburg 2-2 FC Schalke 04 | German Bundesliga |
| 9 | Sat 2 Jan 2021 | 50-3 v Hertha BerlinHertha Berlin 3-0 FC Schalke 04 | German Bundesliga |
| 10 | Sat 9 Jan 2021 | 54-0 v 1899 HoffenheimFC Schalke 04 4-0 1899 Hoffenheim | German Bundesliga |
| 11 | Sun 17 Jan 2021 | 51-3 v Eintracht FrankfurtEintracht Frankfurt 3-1 FC Schalke 04 | German Bundesliga |
| 12 | Wed 20 Jan 2021 | 51-2 v 1. FC KölnFC Schalke 04 1-2 1. FC Köln | German Bundesliga |
| 13 | Sun 24 Jan 2021 | 5 0-4 v Bayern MunichFC Schalke 04 0-4 Bayern Munich | German Bundesliga |
| 14 | Sat 30 Jan 2021 | 51-1 v Werder BremenWerder Bremen 1-1 FC Schalke 04 | German Bundesliga |
| 15 | Sat 6 Feb 2021 | 50-3 v RB LeipzigFC Schalke 04 0-3 RB Leipzig | German Bundesliga |
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