| 1 | Sat 14 Aug 2021 | 10-2 v Warrington TownWarrington Town 2-0 FC United of Manchester | Northern Premier League - Premier Division |
| 2 | Tue 17 Aug 2021 | 13-0 v Morpeth TownFC United of Manchester 3-0 Morpeth Town | Northern Premier League - Premier Division |
| 3 | Sat 21 Aug 2021 | 11-1 v BuxtonFC United of Manchester 1-1 Buxton | Northern Premier League - Premier Division |
| 4 | Tue 24 Aug 2021 | 11-1 v South ShieldsSouth Shields 1-1 FC United of Manchester | Northern Premier League - Premier Division |
| 5 | Sat 4 Sep 2021 | 12-2 v BootleBootle 2-2 FC United of Manchester | Emirates FA Cup First Qualifying Round |
| 6 | Tue 7 Sep 2021 | 13-2 v BootleFC United of Manchester 3-2 Bootle | Emirates FA Cup First Qualifying Round Replay |
| 7 | Sat 11 Sep 2021 | 11-3 v Stafford RangersFC United of Manchester 1-3 Stafford Rangers | Northern Premier League - Premier Division |
| 8 | Tue 14 Sep 2021 | 11-0 v Bamber BridgeFC United of Manchester 1-0 Bamber Bridge | Northern Premier League - Premier Division |
| 9 | Sat 18 Sep 2021 | 11-1 v Blyth SpartansBlyth Spartans 1-1 FC United of Manchester | Emirates FA Cup Second Qualifying Round |
| 10 | Tue 21 Sep 2021 | 10-2 v Blyth SpartansFC United of Manchester 0-2 Blyth Spartans | Emirates FA Cup Second Qualifying Round Replay |
| 11 | Sat 25 Sep 2021 | 12-5 v Stalybridge CelticStalybridge Celtic 5-2 FC United of Manchester | Northern Premier League - Premier Division |
| 12 | Tue 28 Sep 2021 | 16-0 v Scarborough AthleticFC United of Manchester 6-0 Scarborough Athletic | Northern Premier League - Premier Division |
| 13 | Sat 2 Oct 2021 | 10-1 v Matlock TownMatlock Town 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 14 | Tue 5 Oct 2021 | 11-0 v Basford UnitedBasford United 0-1 FC United of Manchester | Northern Premier League - Premier Division |
| 15 | Sat 9 Oct 2021 | 10-2 v Nantwich TownFC United of Manchester 0-2 Nantwich Town | Northern Premier League - Premier Division |
| 16 | Tue 12 Oct 2021 | 10-1 v Lancaster CityLancaster City 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 17 | Sat 16 Oct 2021 | 10-1 v Grantham TownFC United of Manchester 0-1 Grantham Town | Northern Premier League - Premier Division |
| 18 | Sat 23 Oct 2021 | 13-2 v Witton AlbionWitton Albion 2-3 FC United of Manchester | Northern Premier League - Premier Division |
| 19 | Sat 30 Oct 2021 | 12-0 v Runcorn LinnetsRuncorn Linnets 0-2 FC United of Manchester | Buildbase FA Trophy Third Qualifying Round |
| 20 | Sat 6 Nov 2021 | 13-2 v Gainsborough TrinityFC United of Manchester 3-2 Gainsborough Trinity | Northern Premier League - Premier Division |
| 21 | Tue 9 Nov 2021 | 10-1 v Whitby TownWhitby Town 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 22 | Sat 13 Nov 2021 | 12-3 v Marske UnitedMarske United 3-2 FC United of Manchester | Buildbase FA Trophy First Round |
| 23 | Sat 20 Nov 2021 | 11-2 v Atherton CollieriesAtherton Collieries 2-1 FC United of Manchester | Northern Premier League - Premier Division |
| 24 | Sat 27 Nov 2021 | 1 2-0 v MickleoverFC United of Manchester 2-0 Mickleover | Northern Premier League - Premier Division |
| 25 | Sat 11 Dec 2021 | 12-0 v Stafford RangersStafford Rangers 0-2 FC United of Manchester | Northern Premier League - Premier Division |
| 26 | Sat 18 Dec 2021 | 12-1 v BuxtonBuxton 1-2 FC United of Manchester | Northern Premier League - Premier Division |
| 27 | Sat 1 Jan 2022 | 13-3 v RadcliffeRadcliffe 3-3 FC United of Manchester | Northern Premier League - Premier Division |
| 28 | Sat 15 Jan 2022 | 1 0-0 v Bamber BridgeBamber Bridge 0-0 FC United of Manchester | Northern Premier League - Premier Division |
| 29 | Sat 22 Jan 2022 | 12-1 v Stalybridge CelticFC United of Manchester 2-1 Stalybridge Celtic | Northern Premier League - Premier Division |
| 30 | Tue 25 Jan 2022 | 13-4 v Whitby TownFC United of Manchester 3-4 Whitby Town | Northern Premier League - Premier Division |
| 31 | Sat 29 Jan 2022 | 12-1 v Grantham TownGrantham Town 1-2 FC United of Manchester | Northern Premier League - Premier Division |
| 32 | Sat 5 Feb 2022 | 12-0 v Witton AlbionFC United of Manchester 2-0 Witton Albion | Northern Premier League - Premier Division |
| 33 | Tue 8 Feb 2022 | 11-0 v Lancaster CityFC United of Manchester 1-0 Lancaster City | Northern Premier League - Premier Division |
| 34 | Sat 12 Feb 2022 | 12-3 v Gainsborough TrinityGainsborough Trinity 3-2 FC United of Manchester | Northern Premier League - Premier Division |
| 35 | Tue 15 Feb 2022 | 10-1 v Warrington TownFC United of Manchester 0-1 Warrington Town | Northern Premier League - Premier Division |
| 36 | Sat 19 Feb 2022 | 12-2 v Scarborough AthleticScarborough Athletic 2-2 FC United of Manchester | Northern Premier League - Premier Division |
| 37 | Sat 26 Feb 2022 | 11-1 v Matlock TownFC United of Manchester 1-1 Matlock Town | Northern Premier League - Premier Division |
| 38 | Sat 12 Mar 2022 | 10-2 v Nantwich TownNantwich Town 2-0 FC United of Manchester | Northern Premier League - Premier Division |
| 39 | Sat 19 Mar 2022 | 13-2 v Basford UnitedFC United of Manchester 3-2 Basford United | Northern Premier League - Premier Division |
| 40 | Sat 2 Apr 2022 | 12-0 v Atherton CollieriesFC United of Manchester 2-0 Atherton Collieries | Northern Premier League - Premier Division |
| 41 | Sat 9 Apr 2022 | 10-1 v Morpeth TownMorpeth Town 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 42 | Sat 16 Apr 2022 | 10-1 v South ShieldsFC United of Manchester 0-1 South Shields | Northern Premier League - Premier Division |
| 43 | Mon 18 Apr 2022 | 13-0 v Ashton UnitedAshton United 0-3 FC United of Manchester | Northern Premier League - Premier Division |
| 44 | Sat 23 Apr 2022 | 10-2 v Hyde UnitedFC United of Manchester 0-2 Hyde United | Northern Premier League - Premier Division |
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