| 1 | 14/8/2021 | 70-2 v Warrington TownWarrington Town 2-0 FC United of Manchester | Northern Premier League - Premier Division |
| 2 | 17/8/2021 | 73-0 v Morpeth TownFC United of Manchester 3-0 Morpeth Town | Northern Premier League - Premier Division |
| 3 | 21/8/2021 | 161-1 v BuxtonFC United of Manchester 1-1 Buxton | Northern Premier League - Premier Division |
| 4 | 24/8/2021 | 121-1 v South ShieldsSouth Shields 1-1 FC United of Manchester | Northern Premier League - Premier Division |
| 5 | 28/8/2021 | 9 1-2 v Hyde UnitedHyde United 2-1 FC United of Manchester | Northern Premier League - Premier Division |
| 6 | 30/8/2021 | 43-0 v RadcliffeFC United of Manchester 3-0 Radcliffe | Northern Premier League - Premier Division |
| 7 | 14/9/2021 | 111-0 v Bamber BridgeFC United of Manchester 1-0 Bamber Bridge | Northern Premier League - Premier Division |
| 8 | 18/9/2021 | 141-1 v Blyth SpartansBlyth Spartans 1-1 FC United of Manchester | Emirates FA Cup Second Qualifying Round |
| 9 | 21/9/2021 | 110-2 v Blyth SpartansFC United of Manchester 0-2 Blyth Spartans | Emirates FA Cup Second Qualifying Round Replay |
| 10 | 25/9/2021 | 122-5 v Stalybridge CelticStalybridge Celtic 5-2 FC United of Manchester | Northern Premier League - Premier Division |
| 11 | 28/9/2021 | 76-0 v Scarborough AthleticFC United of Manchester 6-0 Scarborough Athletic | Northern Premier League - Premier Division |
| 12 | 2/10/2021 | 70-1 v Matlock TownMatlock Town 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 13 | 5/10/2021 | 71-0 v Basford UnitedBasford United 0-1 FC United of Manchester | Northern Premier League - Premier Division |
| 14 | 9/10/2021 | 70-2 v Nantwich TownFC United of Manchester 0-2 Nantwich Town | Northern Premier League - Premier Division |
| 15 | 12/10/2021 | 70-1 v Lancaster CityLancaster City 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 16 | 16/10/2021 | 70-1 v Grantham TownFC United of Manchester 0-1 Grantham Town | Northern Premier League - Premier Division |
| 17 | 23/10/2021 | 123-2 v Witton AlbionWitton Albion 2-3 FC United of Manchester | Northern Premier League - Premier Division |
| 18 | 30/10/2021 | 122-0 v Runcorn LinnetsRuncorn Linnets 0-2 FC United of Manchester | Buildbase FA Trophy Third Qualifying Round |
| 19 | 6/11/2021 | 143-2 v Gainsborough TrinityFC United of Manchester 3-2 Gainsborough Trinity | Northern Premier League - Premier Division |
| 20 | 9/11/2021 | 140-1 v Whitby TownWhitby Town 1-0 FC United of Manchester | Northern Premier League - Premier Division |
| 21 | 13/11/2021 | 112-3 v Marske UnitedMarske United 3-2 FC United of Manchester | Buildbase FA Trophy First Round |
| 22 | 20/11/2021 | 101-2 v Atherton CollieriesAtherton Collieries 2-1 FC United of Manchester | Northern Premier League - Premier Division |
| 23 | 27/11/2021 | 82-0 v MickleoverFC United of Manchester 2-0 Mickleover | Northern Premier League - Premier Division |
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