| 1 | 7/8/2021 | 13-0 v WidnesGlossop North End 3-0 Widnes | Emirates FA Cup Extra Preliminary Round |
| 2 | 14/8/2021 | 10-0 v Kendal TownKendal Town 0-0 Glossop North End | Northern Premier League - West Division |
| 3 | 17/8/2021 | 13-1 v Runcorn LinnetsGlossop North End 3-1 Runcorn Linnets | Northern Premier League - West Division |
| 4 | 21/8/2021 | 10-1 v Kendal TownGlossop North End 0-1 Kendal Town | Emirates FA Cup Preliminary Round |
| 5 | 24/8/2021 | 11-1 v City of LiverpoolCity of Liverpool 1-1 Glossop North End | Northern Premier League - West Division |
| 6 | 28/8/2021 | 10-2 v ClitheroeGlossop North End 0-2 Clitheroe | Northern Premier League - West Division |
| 7 | 30/8/2021 | 10-1 v TraffordTrafford 1-0 Glossop North End | Northern Premier League - West Division |
| 8 | 4/9/2021 | 10-2 v Newcastle TownGlossop North End 0-2 Newcastle Town | Northern Premier League - West Division |
| 9 | 7/9/2021 | 11-2 v MarineMarine 2-1 Glossop North End | Northern Premier League - West Division |
| 10 | 11/9/2021 | 10-0 v WidnesGlossop North End 0-0 Widnes | Northern Premier League - West Division |
| 11 | 14/9/2021 | 11-2 v Leek TownGlossop North End 1-2 Leek Town | Northern Premier League - West Division |
| 12 | 18/9/2021 | 10-0 v Ramsbottom UnitedRamsbottom United 0-0 Glossop North End | Northern Premier League - West Division |
| 13 | 25/9/2021 | 10-2 v ColneColne 2-0 Glossop North End | Northern Premier League - West Division |
| 14 | 2/10/2021 | 11-3 v Workington AFCGlossop North End 1-3 Workington AFC | Northern Premier League - West Division |
| 15 | 9/10/2021 | 10-3 v Marske UnitedMarske United 3-0 Glossop North End | Buildbase FA Trophy Second Qualifying Round |
| 16 | 16/10/2021 | 10-0 v Market Drayton TownMarket Drayton Town 0-0 Glossop North End | Northern Premier League - West Division |
| 17 | 19/10/2021 | 11-2 v Hyde UnitedGlossop North End 1-2 Hyde United | Manchester Premier Cup First Round |
| 18 | 23/10/2021 | 1 1-1 v Warrington RylandsGlossop North End 1-1 Warrington Rylands | Northern Premier League - West Division |
| 19 | 6/11/2021 | 12-1 v BootleBootle 1-2 Glossop North End | Northern Premier League - West Division |
| 20 | 13/11/2021 | 11-1 v 1874 NorthwichGlossop North End 1-1 1874 Northwich | Northern Premier League - West Division |
| 21 | 20/11/2021 | 12-0 v Prescot CablesPrescot Cables 0-2 Glossop North End | Northern Premier League - West Division |
| 22 | 4/12/2021 | 1 2-2 v Kidsgrove AthleticGlossop North End 2-2 Kidsgrove Athletic | Northern Premier League - West Division |
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