| 1 | 7/8/2021 | 13-0 v WidnesGlossop North End 3-0 Widnes | Emirates FA Cup Extra Preliminary Round |
| 2 | 14/8/2021 | 10-0 v Kendal TownKendal Town 0-0 Glossop North End | Northern Premier League - West Division |
| 3 | 17/8/2021 | 13-1 v Runcorn LinnetsGlossop North End 3-1 Runcorn Linnets | Northern Premier League - West Division |
| 4 | 21/8/2021 | 10-1 v Kendal TownGlossop North End 0-1 Kendal Town | Emirates FA Cup Preliminary Round |
| 5 | 24/8/2021 | 11-1 v City of LiverpoolCity of Liverpool 1-1 Glossop North End | Northern Premier League - West Division |
| 6 | 28/8/2021 | 10-2 v ClitheroeGlossop North End 0-2 Clitheroe | Northern Premier League - West Division |
| 7 | 30/8/2021 | 10-1 v TraffordTrafford 1-0 Glossop North End | Northern Premier League - West Division |
| 8 | 4/9/2021 | 10-2 v Newcastle TownGlossop North End 0-2 Newcastle Town | Northern Premier League - West Division |
| 9 | 7/9/2021 | 11-2 v MarineMarine 2-1 Glossop North End | Northern Premier League - West Division |
| 10 | 11/9/2021 | 10-0 v WidnesGlossop North End 0-0 Widnes | Northern Premier League - West Division |
| 11 | 14/9/2021 | 11-2 v Leek TownGlossop North End 1-2 Leek Town | Northern Premier League - West Division |
| 12 | 18/9/2021 | 10-0 v Ramsbottom UnitedRamsbottom United 0-0 Glossop North End | Northern Premier League - West Division |
| 13 | 25/9/2021 | 10-2 v ColneColne 2-0 Glossop North End | Northern Premier League - West Division |
| 14 | 2/10/2021 | 11-3 v Workington AFCGlossop North End 1-3 Workington AFC | Northern Premier League - West Division |
| 15 | 9/10/2021 | 10-3 v Marske UnitedMarske United 3-0 Glossop North End | Buildbase FA Trophy Second Qualifying Round |
| 16 | 16/10/2021 | 10-0 v Market Drayton TownMarket Drayton Town 0-0 Glossop North End | Northern Premier League - West Division |
| 17 | 19/10/2021 | 11-2 v Hyde UnitedGlossop North End 1-2 Hyde United | Manchester Premier Cup First Round |
| 18 | 23/10/2021 | 1 1-1 v Warrington RylandsGlossop North End 1-1 Warrington Rylands | Northern Premier League - West Division |
| 19 | 6/11/2021 | 12-1 v BootleBootle 1-2 Glossop North End | Northern Premier League - West Division |
| 20 | 13/11/2021 | 11-1 v 1874 NorthwichGlossop North End 1-1 1874 Northwich | Northern Premier League - West Division |
| 21 | 20/11/2021 | 12-0 v Prescot CablesPrescot Cables 0-2 Glossop North End | Northern Premier League - West Division |
| 22 | 4/12/2021 | 1 2-2 v Kidsgrove AthleticGlossop North End 2-2 Kidsgrove Athletic | Northern Premier League - West Division |
| 23 | 11/12/2021 | 11-1 v Runcorn LinnetsRuncorn Linnets 1-1 Glossop North End | Northern Premier League - West Division |
| 24 | 18/12/2021 | 12-0 v Kendal TownGlossop North End 2-0 Kendal Town | Northern Premier League - West Division |
| 25 | 27/12/2021 | 10-0 v MossleyMossley 0-0 Glossop North End | Northern Premier League - West Division |
| 26 | 1/1/2022 | 11-1 v TraffordGlossop North End 1-1 Trafford | Northern Premier League - West Division |
| 27 | 8/1/2022 | 11-5 v Workington AFCWorkington AFC 5-1 Glossop North End | Northern Premier League - West Division |
| 28 | 15/1/2022 | 13-2 v ColneGlossop North End 3-2 Colne | Northern Premier League - West Division |
| 29 | 22/1/2022 | 13-2 v Market Drayton TownGlossop North End 3-2 Market Drayton Town | Northern Premier League - West Division |
| 30 | 29/1/2022 | 10-4 v Warrington RylandsWarrington Rylands 4-0 Glossop North End | Northern Premier League - West Division |
| 31 | 8/2/2022 | 11-0 v 1874 Northwich1874 Northwich 0-1 Glossop North End | Northern Premier League - West Division |
| 32 | 11/2/2022 | 10-2 v Curzon AshtonGlossop North End 0-2 Curzon Ashton | Friendly |
| 33 | 19/2/2022 | 11-2 v Leek TownLeek Town 2-1 Glossop North End | Northern Premier League - West Division |
| 34 | 26/2/2022 | 13-0 v Ramsbottom UnitedGlossop North End 3-0 Ramsbottom United | Northern Premier League - West Division |
| 35 | 1/3/2022 | 13-2 v BootleGlossop North End 3-2 Bootle | Northern Premier League - West Division |
| 36 | 12/3/2022 | 10-2 v WidnesWidnes 2-0 Glossop North End | Northern Premier League - West Division |
| 37 | 19/3/2022 | 10-2 v MarineGlossop North End 0-2 Marine | Northern Premier League - West Division |
| 38 | 26/3/2022 | 10-0 v Newcastle TownNewcastle Town 0-0 Glossop North End | Northern Premier League - West Division |
| 39 | 2/4/2022 | 10-2 v Prescot CablesGlossop North End 0-2 Prescot Cables | Northern Premier League - West Division |
| 40 | 9/4/2022 | 12-2 v City of LiverpoolGlossop North End 2-2 City of Liverpool | Northern Premier League - West Division |
| 41 | 16/4/2022 | 10-2 v ClitheroeClitheroe 2-0 Glossop North End | Northern Premier League - West Division |
| 42 | 18/4/2022 | 10-2 v MossleyGlossop North End 0-2 Mossley | Northern Premier League - West Division |
| 43 | 23/4/2022 | 1 0-3 v Kidsgrove AthleticKidsgrove Athletic 3-0 Glossop North End | Northern Premier League - West Division |
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