| 1 | Fri 13 Aug 2021 | 30-1 v sc HeerenveenGo Ahead Eagles 0-1 sc Heerenveen | Dutch Eredivisie |
| 2 | Sun 22 Aug 2021 | 30-2 v FeyenoordFeyenoord 2-0 Go Ahead Eagles | Dutch Eredivisie |
| 3 | Sat 28 Aug 2021 | 32-0 v Sparta RotterdamGo Ahead Eagles 2-0 Sparta Rotterdam | Dutch Eredivisie |
| 4 | Sun 19 Sep 2021 | 31-0 v PEC ZwolleGo Ahead Eagles 1-0 PEC Zwolle | Dutch Eredivisie |
| 5 | Wed 22 Sep 2021 | 31-2 v PSV EindhovenGo Ahead Eagles 1-2 PSV Eindhoven | Dutch Eredivisie |
| 6 | Sun 26 Sep 2021 | 3 0-5 v AZ AlkmaarAZ Alkmaar 5-0 Go Ahead Eagles | Dutch Eredivisie |
| 7 | Sun 24 Oct 2021 | 32-1 v VitesseVitesse 1-2 Go Ahead Eagles | Dutch Eredivisie |
| 8 | Sun 31 Oct 2021 | 34-3 v Fortuna SittardGo Ahead Eagles 4-3 Fortuna Sittard | Dutch Eredivisie |
| 9 | Sun 7 Nov 2021 | 30-0 v AjaxAjax 0-0 Go Ahead Eagles | Dutch Eredivisie |
| 10 | Sun 21 Nov 2021 | 30-1 v FC GroningenGo Ahead Eagles 0-1 FC Groningen | Dutch Eredivisie |
| 11 | Sat 27 Nov 2021 | 31-0 v Willem IIWillem II 0-1 Go Ahead Eagles | Dutch Eredivisie |
| 12 | Sun 5 Dec 2021 | 31-2 v FC TwenteGo Ahead Eagles 1-2 FC Twente | Dutch Eredivisie |
| 13 | Sun 19 Dec 2021 | 30-2 v NEC NijmegenGo Ahead Eagles 0-2 NEC Nijmegen | Dutch Eredivisie |
| 14 | Thu 23 Dec 2021 | 30-2 v PSV EindhovenPSV Eindhoven 2-0 Go Ahead Eagles | Dutch Eredivisie |
| 15 | Sat 15 Jan 2022 | 30-2 v RKC WaalwijkGo Ahead Eagles 0-2 RKC Waalwijk | Dutch Eredivisie |
| 16 | Sun 20 Feb 2022 | 32-2 v FC TwenteFC Twente 2-2 Go Ahead Eagles | Dutch Eredivisie |
| 17 | Sun 27 Feb 2022 | 32-1 v AjaxGo Ahead Eagles 2-1 Ajax | Dutch Eredivisie |
| 18 | Sat 5 Mar 2022 | 31-1 v FC UtrechtGo Ahead Eagles 1-1 FC Utrecht | Dutch Eredivisie |
| 19 | Sat 12 Mar 2022 | 30-1 v Sparta RotterdamSparta Rotterdam 1-0 Go Ahead Eagles | Dutch Eredivisie |
| 20 | Sun 3 Apr 2022 | 31-0 v PEC ZwollePEC Zwolle 0-1 Go Ahead Eagles | Dutch Eredivisie |
| 21 | Fri 8 Apr 2022 | 34-0 v Willem IIGo Ahead Eagles 4-0 Willem II | Dutch Eredivisie |
| 22 | Sun 24 Apr 2022 | 30-1 v Fortuna SittardFortuna Sittard 1-0 Go Ahead Eagles | Dutch Eredivisie |
| 23 | Sun 1 May 2022 | 31-2 v VitesseGo Ahead Eagles 1-2 Vitesse | Dutch Eredivisie |
| 24 | Sun 8 May 2022 | 30-1 v NEC NijmegenNEC Nijmegen 1-0 Go Ahead Eagles | Dutch Eredivisie |
| 25 | Wed 11 May 2022 | 30-1 v FeyenoordGo Ahead Eagles 0-1 Feyenoord | Dutch Eredivisie |
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