| 1 | Sat 14 Aug 2021 | 42-3 v BarrowBarrow 3-2 Hartlepool United | Sky Bet League Two |
| 2 | Sat 21 Aug 2021 | 4 2-0 v WalsallHartlepool United 2-0 Walsall | Sky Bet League Two |
| 3 | Sat 28 Aug 2021 | 4 2-1 v Carlisle UnitedHartlepool United 2-1 Carlisle United | Sky Bet League Two |
| 4 | Sat 4 Sep 2021 | 40-1 v Tranmere RoversTranmere Rovers 1-0 Hartlepool United | Sky Bet League Two |
| 5 | Sat 11 Sep 2021 | 41-0 v Bristol RoversHartlepool United 1-0 Bristol Rovers | Sky Bet League Two |
| 6 | Tue 14 Sep 2021 | 40-1 v Sutton UnitedSutton United 1-0 Hartlepool United | Sky Bet League Two |
| 7 | Sat 18 Sep 2021 | 4 0-0 v Oldham AthleticOldham Athletic 0-0 Hartlepool United | Sky Bet League Two |
| 8 | Sat 23 Oct 2021 | 43-2 v Harrogate TownHartlepool United 3-2 Harrogate Town | Sky Bet League Two |
| 9 | Sat 30 Oct 2021 | 40-5 v Leyton OrientLeyton Orient 5-0 Hartlepool United | Sky Bet League Two |
| 10 | Sat 6 Nov 2021 | 4 2-2 v Wycombe WanderersHartlepool United 2-2 Wycombe Wanderers | Emirates FA Cup First Round |
| 11 | Fri 12 Nov 2021 | 41-2 v Newport CountyHartlepool United 1-2 Newport County | Sky Bet League Two |
| 12 | Tue 16 Nov 2021 | 4 1-0 v Wycombe WanderersWycombe Wanderers 0-1 Hartlepool United | Emirates FA Cup First Round Replay |
| 13 | Sat 20 Nov 2021 | 4 1-3 v Forest Green RoversHartlepool United 1-3 Forest Green Rovers | Sky Bet League Two |
| 14 | Tue 23 Nov 2021 | 41-3 v Swindon TownSwindon Town 3-1 Hartlepool United | Sky Bet League Two |
| 15 | Sat 27 Nov 2021 | 40-2 v Port ValePort Vale 2-0 Hartlepool United | Sky Bet League Two |
| 16 | Sat 4 Dec 2021 | 41-0 v Lincoln CityLincoln City 0-1 Hartlepool United | Emirates FA Cup Second Round |
| 17 | Wed 8 Dec 2021 | 42-1 v RochdaleHartlepool United 2-1 Rochdale | Sky Bet League Two |
| 18 | Sat 11 Dec 2021 | 40-0 v Scunthorpe UnitedHartlepool United 0-0 Scunthorpe United | Sky Bet League Two |
| 19 | Sun 26 Dec 2021 | 42-3 v Mansfield TownMansfield Town 3-2 Hartlepool United | Sky Bet League Two |
| 20 | Sat 1 Jan 2022 | 40-0 v Oldham AthleticHartlepool United 0-0 Oldham Athletic | Sky Bet League Two |
| 21 | Sat 8 Jan 2022 | 42-1 v BlackpoolHartlepool United 2-1 Blackpool | Emirates FA Cup Third Round |
| 22 | Sat 15 Jan 2022 | 4 0-2 v Bristol RoversBristol Rovers 2-0 Hartlepool United | Sky Bet League Two |
| 23 | Tue 18 Jan 2022 | 40-0 v Carlisle UnitedCarlisle United 0-0 Hartlepool United | Sky Bet League Two |
| 24 | Sat 22 Jan 2022 | 41-1 v StevenageHartlepool United 1-1 Stevenage | Sky Bet League Two |
| 25 | Sat 29 Jan 2022 | 40-0 v Exeter CityExeter City 0-0 Hartlepool United | Sky Bet League Two |
| 26 | Sat 5 Feb 2022 | 40-2 v Crystal PalaceCrystal Palace 2-0 Hartlepool United | Emirates FA Cup Fourth Round |
| 27 | Sat 12 Feb 2022 | 41-0 v Crawley TownCrawley Town 0-1 Hartlepool United | Sky Bet League Two |
| 28 | Tue 15 Feb 2022 | 41-0 v Tranmere RoversHartlepool United 1-0 Tranmere Rovers | Sky Bet League Two |
| 29 | Sat 26 Feb 2022 | 41-3 v WalsallWalsall 3-1 Hartlepool United | Sky Bet League Two |
| 30 | Sat 5 Mar 2022 | 42-1 v Harrogate TownHarrogate Town 1-2 Hartlepool United | Sky Bet League Two |
| 31 | Fri 18 Mar 2022 | 4 3-2 v Newport CountyNewport County 2-3 Hartlepool United | Sky Bet League Two |
| 32 | Sat 26 Mar 2022 | 4 0-2 v Northampton TownNorthampton Town 2-0 Hartlepool United | Sky Bet League Two |
| 33 | Sat 9 Apr 2022 | 41-1 v Forest Green RoversForest Green Rovers 1-1 Hartlepool United | Sky Bet League Two |
| 34 | Fri 15 Apr 2022 | 40-1 v Port ValeHartlepool United 0-1 Port Vale | Sky Bet League Two |
| 35 | Mon 18 Apr 2022 | 41-2 v RochdaleRochdale 2-1 Hartlepool United | Sky Bet League Two |
| 36 | Sat 7 May 2022 | 40-2 v Colchester UnitedHartlepool United 0-2 Colchester United | Sky Bet League Two |
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