| 1 | Sat 14 Aug 2021 | 22-3 v BarrowBarrow 3-2 Hartlepool United | Sky Bet League Two |
| 2 | Sat 21 Aug 2021 | 22-0 v WalsallHartlepool United 2-0 Walsall | Sky Bet League Two |
| 3 | Sat 28 Aug 2021 | 22-1 v Carlisle UnitedHartlepool United 2-1 Carlisle United | Sky Bet League Two |
| 4 | Sat 4 Sep 2021 | 2 0-1 v Tranmere RoversTranmere Rovers 1-0 Hartlepool United | Sky Bet League Two |
| 5 | Sat 11 Sep 2021 | 2 1-0 v Bristol RoversHartlepool United 1-0 Bristol Rovers | Sky Bet League Two |
| 6 | Tue 14 Sep 2021 | 20-1 v Sutton UnitedSutton United 1-0 Hartlepool United | Sky Bet League Two |
| 7 | Sat 18 Sep 2021 | 2 0-0 v Oldham AthleticOldham Athletic 0-0 Hartlepool United | Sky Bet League Two |
| 8 | Sat 25 Sep 2021 | 21-1 v Exeter CityHartlepool United 1-1 Exeter City | Sky Bet League Two |
| 9 | Sat 2 Oct 2021 | 20-2 v StevenageStevenage 2-0 Hartlepool United | Sky Bet League Two |
| 10 | Sat 9 Oct 2021 | 22-1 v Northampton TownHartlepool United 2-1 Northampton Town | Sky Bet League Two |
| 11 | Sat 16 Oct 2021 | 2 0-2 v Salford CitySalford City 2-0 Hartlepool United | Sky Bet League Two |
| 12 | Tue 19 Oct 2021 | 23-1 v Bradford CityBradford City 1-3 Hartlepool United | Sky Bet League Two |
| 13 | Sat 23 Oct 2021 | 23-2 v Harrogate TownHartlepool United 3-2 Harrogate Town | Sky Bet League Two |
| 14 | Tue 16 Nov 2021 | 21-0 v Wycombe WanderersWycombe Wanderers 0-1 Hartlepool United | Emirates FA Cup First Round Replay |
| 15 | Sat 20 Nov 2021 | 2 1-3 v Forest Green RoversHartlepool United 1-3 Forest Green Rovers | Sky Bet League Two |
| 16 | Wed 8 Dec 2021 | 22-1 v RochdaleHartlepool United 2-1 Rochdale | Sky Bet League Two |
| 17 | Sat 11 Dec 2021 | 20-0 v Scunthorpe UnitedHartlepool United 0-0 Scunthorpe United | Sky Bet League Two |
| 18 | Sun 26 Dec 2021 | 22-3 v Mansfield TownMansfield Town 3-2 Hartlepool United | Sky Bet League Two |
| 19 | Sat 1 Jan 2022 | 20-0 v Oldham AthleticHartlepool United 0-0 Oldham Athletic | Sky Bet League Two |
| 20 | Sat 8 Jan 2022 | 22-1 v BlackpoolHartlepool United 2-1 Blackpool | Emirates FA Cup Third Round |
| 21 | Sat 15 Jan 2022 | 2 0-2 v Bristol RoversBristol Rovers 2-0 Hartlepool United | Sky Bet League Two |
| 22 | Tue 25 Jan 2022 | 22-2 v Charlton AthleticHartlepool United 2-2 Charlton Athletic | Papa John’s Trophy Quarter Final |
| 23 | Sat 29 Jan 2022 | 20-0 v Exeter CityExeter City 0-0 Hartlepool United | Sky Bet League Two |
| 24 | Sat 5 Feb 2022 | 20-2 v Crystal PalaceCrystal Palace 2-0 Hartlepool United | Emirates FA Cup Fourth Round |
| 25 | Tue 8 Feb 2022 | 23-1 v BarrowHartlepool United 3-1 Barrow | Sky Bet League Two |
| 26 | Sat 12 Feb 2022 | 21-0 v Crawley TownCrawley Town 0-1 Hartlepool United | Sky Bet League Two |
| 27 | Tue 15 Feb 2022 | 21-0 v Tranmere RoversHartlepool United 1-0 Tranmere Rovers | Sky Bet League Two |
| 28 | Sat 26 Feb 2022 | 21-3 v WalsallWalsall 3-1 Hartlepool United | Sky Bet League Two |
| 29 | Sat 5 Mar 2022 | 22-1 v Harrogate TownHarrogate Town 1-2 Hartlepool United | Sky Bet League Two |
| 30 | Wed 9 Mar 2022 | 22-2 v Rotherham UnitedHartlepool United 2-2 Rotherham United | Papa John’s Trophy Semi Final |
| 31 | Sat 12 Mar 2022 | 20-0 v Leyton OrientHartlepool United 0-0 Leyton Orient | Sky Bet League Two |
| 32 | Tue 15 Mar 2022 | 20-2 v Bradford CityHartlepool United 0-2 Bradford City | Sky Bet League Two |
| 33 | Fri 18 Mar 2022 | 2 3-2 v Newport CountyNewport County 2-3 Hartlepool United | Sky Bet League Two |
| 34 | Sat 26 Mar 2022 | 20-2 v Northampton TownNorthampton Town 2-0 Hartlepool United | Sky Bet League Two |
| 35 | Tue 29 Mar 2022 | 22-2 v Mansfield TownHartlepool United 2-2 Mansfield Town | Sky Bet League Two |
| 36 | Sat 2 Apr 2022 | 20-2 v Salford CityHartlepool United 0-2 Salford City | Sky Bet League Two |
| 37 | Sat 9 Apr 2022 | 21-1 v Forest Green RoversForest Green Rovers 1-1 Hartlepool United | Sky Bet League Two |
| 38 | Fri 15 Apr 2022 | 20-1 v Port ValeHartlepool United 0-1 Port Vale | Sky Bet League Two |
| 39 | Sat 23 Apr 2022 | 20-3 v Swindon TownHartlepool United 0-3 Swindon Town | Sky Bet League Two |
| 40 | Sat 30 Apr 2022 | 21-1 v Scunthorpe UnitedScunthorpe United 1-1 Hartlepool United | Sky Bet League Two |
| 41 | Sat 7 May 2022 | 20-2 v Colchester UnitedHartlepool United 0-2 Colchester United | Sky Bet League Two |
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