| 1 | 14/8/2021 | 23 0-2 v PSV EindhovenHeracles Almelo 0-2 PSV Eindhoven | Dutch Eredivisie |
| 2 | 21/8/2021 | 23 1-1 v Sparta RotterdamSparta Rotterdam 1-1 Heracles Almelo | Dutch Eredivisie |
| 3 | 29/8/2021 | 23 0-1 v NEC NijmegenHeracles Almelo 0-1 NEC Nijmegen | Dutch Eredivisie |
| 4 | 19/9/2021 | 233-2 v AZ AlkmaarHeracles Almelo 3-2 AZ Alkmaar | Dutch Eredivisie |
| 5 | 26/9/2021 | 231-0 v RKC WaalwijkHeracles Almelo 1-0 RKC Waalwijk | Dutch Eredivisie |
| 6 | 2/10/2021 | 233-2 v Willem IIHeracles Almelo 3-2 Willem II | Dutch Eredivisie |
| 7 | 16/10/2021 | 23 2-4 v Go Ahead EaglesGo Ahead Eagles 4-2 Heracles Almelo | Dutch Eredivisie |
| 8 | 30/10/2021 | 230-0 v AjaxHeracles Almelo 0-0 Ajax | Dutch Eredivisie |
| 9 | 5/11/2021 | 230-1 v FC TwenteFC Twente 1-0 Heracles Almelo | Dutch Eredivisie |
| 10 | 20/11/2021 | 233-1 v Fortuna SittardHeracles Almelo 3-1 Fortuna Sittard | Dutch Eredivisie |
| 11 | 28/11/2021 | 230-1 v FC UtrechtFC Utrecht 1-0 Heracles Almelo | Dutch Eredivisie |
| 12 | 1/12/2021 | 231-2 v FeyenoordFeyenoord 2-1 Heracles Almelo | Dutch Eredivisie |
| 13 | 4/12/2021 | 230-1 v sc HeerenveenHeracles Almelo 0-1 sc Heerenveen | Dutch Eredivisie |
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