| 1 | Sat 5 Aug 2017 | 0-2 v Sutton UnitedSutton United 2-0 Leyton Orient | National League |
| 2 | Tue 8 Aug 2017 | 7 3-1 v Solihull MoorsLeyton Orient 3-1 Solihull Moors | National League |
| 3 | Sat 12 Aug 2017 | 72-0 v Maidstone UnitedLeyton Orient 2-0 Maidstone United | National League |
| 4 | Tue 15 Aug 2017 | 71-6 v BromleyBromley 6-1 Leyton Orient | National League |
| 5 | Sat 19 Aug 2017 | 7 2-0 v WokingWoking 0-2 Leyton Orient | National League |
| 6 | Sat 26 Aug 2017 | 71-1 v EastleighLeyton Orient 1-1 Eastleigh | National League |
| 7 | Mon 28 Aug 2017 | 71-0 v Maidenhead UnitedMaidenhead United 0-1 Leyton Orient | National League |
| 8 | Sat 2 Sep 2017 | 74-1 v GuiseleyLeyton Orient 4-1 Guiseley | National League |
| 9 | Sat 9 Sep 2017 | 7 0-2 v Boreham WoodBoreham Wood 2-0 Leyton Orient | National League |
| 10 | Tue 12 Sep 2017 | 70-3 v FC Halifax TownLeyton Orient 0-3 FC Halifax Town | National League |
| 11 | Sat 16 Sep 2017 | 71-2 v Hartlepool UnitedLeyton Orient 1-2 Hartlepool United | National League |
| 12 | Sat 23 Sep 2017 | 7 2-2 v Aldershot TownAldershot Town 2-2 Leyton Orient | National League |
| 13 | Sat 30 Sep 2017 | 71-2 v AFC FyldeLeyton Orient 1-2 AFC Fylde | National League |
| 14 | Wed 4 Oct 2017 | 71-2 v Tranmere RoversTranmere Rovers 2-1 Leyton Orient | National League |
| 15 | Sat 7 Oct 2017 | 72-2 v BarrowBarrow 2-2 Leyton Orient | National League |
| 16 | Tue 24 Oct 2017 | 7 0-2 v GatesheadLeyton Orient 0-2 Gateshead | National League |
| 17 | Sat 11 Nov 2017 | 71-2 v Ebbsfleet UnitedEbbsfleet United 2-1 Leyton Orient | National League |
| 18 | Sat 18 Nov 2017 | 71-1 v Dover AthleticLeyton Orient 1-1 Dover Athletic | National League |
| 19 | Tue 21 Nov 2017 | 72-2 v ChesterLeyton Orient 2-2 Chester | National League |
| 20 | Sat 25 Nov 2017 | 70-3 v Torquay UnitedTorquay United 3-0 Leyton Orient | National League |
| 21 | Sat 2 Dec 2017 | 70-1 v Solihull MoorsSolihull Moors 1-0 Leyton Orient | National League |
| 22 | Sat 9 Dec 2017 | 7 4-1 v Sutton UnitedLeyton Orient 4-1 Sutton United | National League |
| 23 | Sat 16 Dec 2017 | 72-1 v Haringey BoroughHaringey Borough 1-2 Leyton Orient | Buildbase FA Trophy First Round |
| 24 | Sat 23 Dec 2017 | 7 2-0 v Maidstone UnitedMaidstone United 0-2 Leyton Orient | National League |
| 25 | Tue 26 Dec 2017 | 72-0 v Dagenham & RedbridgeLeyton Orient 2-0 Dagenham & Redbridge | National League |
| 26 | Sat 30 Dec 2017 | 70-1 v BromleyLeyton Orient 0-1 Bromley | National League |
| 27 | Sat 6 Jan 2018 | 70-0 v Boreham WoodLeyton Orient 0-0 Boreham Wood | National League |
| 28 | Sat 27 Jan 2018 | 72-3 v Aldershot TownLeyton Orient 2-3 Aldershot Town | National League |
| 29 | Tue 30 Jan 2018 | 72-1 v FC Halifax TownFC Halifax Town 1-2 Leyton Orient | National League |
| 30 | Sat 3 Feb 2018 | 74-3 v Dover AthleticDover Athletic 3-4 Leyton Orient | Buildbase FA Trophy Third Round |
| 31 | Sat 17 Mar 2018 | 70-0 v EastleighEastleigh 0-0 Leyton Orient | National League |
| 32 | Sat 24 Mar 2018 | 73-0 v WokingLeyton Orient 3-0 Woking | National League |
| 33 | Fri 30 Mar 2018 | 73-1 v GuiseleyGuiseley 1-3 Leyton Orient | National League |
| 34 | Sat 7 Apr 2018 | 74-1 v BarrowLeyton Orient 4-1 Barrow | National League |
| 35 | Sat 14 Apr 2018 | 71-1 v Macclesfield TownMacclesfield Town 1-1 Leyton Orient | National League |
| 36 | Tue 17 Apr 2018 | 70-1 v Hartlepool UnitedHartlepool United 1-0 Leyton Orient | National League |
| 37 | Sat 21 Apr 2018 | 7 1-0 v WrexhamLeyton Orient 1-0 Wrexham | National League |
| 38 | Tue 24 Apr 2018 | 70-1 v Maidenhead UnitedLeyton Orient 0-1 Maidenhead United | National League |
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