| 1 | Tue 9 Nov 2021 | 211-0 v Charlton AthleticLeyton Orient 1-0 Charlton Athletic | Papa John’s Trophy |
| 2 | Sat 4 Dec 2021 | 214-0 v Tranmere RoversLeyton Orient 4-0 Tranmere Rovers | Emirates FA Cup Second Round |
| 3 | Sat 11 Dec 2021 | 211-2 v Crawley TownLeyton Orient 1-2 Crawley Town | Sky Bet League Two |
| 4 | Sat 18 Dec 2021 | 210-1 v Tranmere RoversTranmere Rovers 1-0 Leyton Orient | Sky Bet League Two |
| 5 | Sun 9 Jan 2022 | 210-2 v Stoke CityStoke City 2-0 Leyton Orient | Emirates FA Cup Third Round |
| 6 | Sat 22 Jan 2022 | 210-0 v Port ValeLeyton Orient 0-0 Port Vale | Sky Bet League Two |
| 7 | Sat 29 Jan 2022 | 210-2 v Mansfield TownMansfield Town 2-0 Leyton Orient | Sky Bet League Two |
| 8 | Sat 5 Feb 2022 | 21 0-1 v Colchester UnitedLeyton Orient 0-1 Colchester United | Sky Bet League Two |
| 9 | Tue 8 Feb 2022 | 210-1 v Exeter CityExeter City 1-0 Leyton Orient | Sky Bet League Two |
| 10 | Tue 22 Feb 2022 | 210-2 v Bristol RoversLeyton Orient 0-2 Bristol Rovers | Sky Bet League Two |
| 11 | Sat 26 Feb 2022 | 210-1 v Carlisle UnitedLeyton Orient 0-1 Carlisle United | Sky Bet League Two |
| 12 | Tue 1 Mar 2022 | 21 2-2 v Colchester UnitedColchester United 2-2 Leyton Orient | Sky Bet League Two |
| 13 | Sat 5 Mar 2022 | 212-2 v StevenageLeyton Orient 2-2 Stevenage | Sky Bet League Two |
| 14 | Tue 22 Mar 2022 | 213-0 v Harrogate TownHarrogate Town 0-3 Leyton Orient | Sky Bet League Two |
| 15 | Sat 9 Apr 2022 | 210-1 v Sutton UnitedSutton United 1-0 Leyton Orient | Sky Bet League Two |
| 16 | Fri 15 Apr 2022 | 213-0 v Scunthorpe UnitedLeyton Orient 3-0 Scunthorpe United | Sky Bet League Two |
| 17 | Sat 30 Apr 2022 | 212-0 v Crawley TownCrawley Town 0-2 Leyton Orient | Sky Bet League Two |
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