| 1 | Sat 22 Jan 2022 | 140-0 v Port ValeLeyton Orient 0-0 Port Vale | Sky Bet League Two |
| 2 | Tue 25 Jan 2022 | 140-1 v Newport CountyLeyton Orient 0-1 Newport County | Sky Bet League Two |
| 3 | Sat 29 Jan 2022 | 140-2 v Mansfield TownMansfield Town 2-0 Leyton Orient | Sky Bet League Two |
| 4 | Tue 1 Feb 2022 | 141-1 v Bradford CityBradford City 1-1 Leyton Orient | Sky Bet League Two |
| 5 | Sat 5 Feb 2022 | 140-1 v Colchester UnitedLeyton Orient 0-1 Colchester United | Sky Bet League Two |
| 6 | Tue 8 Feb 2022 | 140-1 v Exeter CityExeter City 1-0 Leyton Orient | Sky Bet League Two |
| 7 | Sat 12 Feb 2022 | 140-2 v Salford CityLeyton Orient 0-2 Salford City | Sky Bet League Two |
| 8 | Tue 22 Feb 2022 | 14 0-2 v Bristol RoversLeyton Orient 0-2 Bristol Rovers | Sky Bet League Two |
| 9 | Sat 26 Feb 2022 | 140-1 v Carlisle UnitedLeyton Orient 0-1 Carlisle United | Sky Bet League Two |
| 10 | Tue 1 Mar 2022 | 142-2 v Colchester UnitedColchester United 2-2 Leyton Orient | Sky Bet League Two |
| 11 | Tue 15 Mar 2022 | 141-1 v Forest Green RoversForest Green Rovers 1-1 Leyton Orient | Sky Bet League Two |
| 12 | Sat 19 Mar 2022 | 143-1 v RochdaleLeyton Orient 3-1 Rochdale | Sky Bet League Two |
| 13 | Tue 22 Mar 2022 | 143-0 v Harrogate TownHarrogate Town 0-3 Leyton Orient | Sky Bet League Two |
| 14 | Sat 26 Mar 2022 | 142-0 v BarrowLeyton Orient 2-0 Barrow | Sky Bet League Two |
| 15 | Tue 29 Mar 2022 | 140-2 v Oldham AthleticOldham Athletic 2-0 Leyton Orient | Sky Bet League Two |
| 16 | Sat 2 Apr 2022 | 142-0 v WalsallWalsall 0-2 Leyton Orient | Sky Bet League Two |
| 17 | Sat 9 Apr 2022 | 14 0-1 v Sutton UnitedSutton United 1-0 Leyton Orient | Sky Bet League Two |
| 18 | Sat 23 Apr 2022 | 142-4 v Northampton TownLeyton Orient 2-4 Northampton Town | Sky Bet League Two |
| 19 | Sat 30 Apr 2022 | 142-0 v Crawley TownCrawley Town 0-2 Leyton Orient | Sky Bet League Two |
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