| 1 | 22/8/2020 | 61-1 v RennesLille 1-1 Rennes | French Ligue 1 |
| 2 | 30/8/2020 | 61-0 v ReimsReims 0-1 Lille | French Ligue 1 |
| 3 | 13/9/2020 | 61-0 v MetzLille 1-0 Metz | French Ligue 1 |
| 4 | 20/9/2020 | 61-1 v MarseilleMarseille 1-1 Lille | French Ligue 1 |
| 5 | 25/9/2020 | 62-0 v NantesLille 2-0 Nantes | French Ligue 1 |
| 6 | 4/10/2020 | 63-0 v StrasbourgStrasbourg 0-3 Lille | French Ligue 1 |
| 7 | 18/10/2020 | 64-0 v LensLille 4-0 Lens | French Ligue 1 |
| 8 | 22/10/2020 | 64-1 v Sparta PragueSparta Prague 1-4 Lille | Europa League Group H |
| 9 | 25/10/2020 | 6 1-1 v NiceNice 1-1 Lille | French Ligue 1 |
| 10 | 1/11/2020 | 6 1-1 v LyonLille 1-1 Lyon | French Ligue 1 |
| 11 | 5/11/2020 | 63-0 v AC MilanAC Milan 0-3 Lille | Europa League Group H |
| 12 | 8/11/2020 | 6 2-3 v BrestBrest 3-2 Lille | French Ligue 1 |
| 13 | 26/11/2020 | 61-1 v AC MilanLille 1-1 AC Milan | Europa League Group H |
| 14 | 29/11/2020 | 61-1 v Saint ÉtienneSaint Étienne 1-1 Lille | French Ligue 1 |
| 15 | 3/12/2020 | 62-1 v Sparta PragueLille 2-1 Sparta Prague | Europa League Group H |
| 16 | 6/12/2020 | 62-1 v MonacoLille 2-1 Monaco | French Ligue 1 |
| 17 | 10/12/2020 | 62-3 v CelticCeltic 3-2 Lille | Europa League Group H |
| 18 | 13/12/2020 | 62-1 v BordeauxLille 2-1 Bordeaux | French Ligue 1 |
| 19 | 16/12/2020 | 62-0 v DijonDijon 0-2 Lille | French Ligue 1 |
| 20 | 20/12/2020 | 60-0 v Paris St GermainLille 0-0 Paris St Germain | French Ligue 1 |
| 21 | 23/12/2020 | 63-2 v MontpellierMontpellier 2-3 Lille | French Ligue 1 |
| 22 | 6/1/2021 | 6 1-2 v AngersLille 1-2 Angers | French Ligue 1 |
| 23 | 9/1/2021 | 61-0 v NîmesNîmes 0-1 Lille | French Ligue 1 |
| 24 | 17/1/2021 | 62-1 v ReimsLille 2-1 Reims | French Ligue 1 |
| 25 | 24/1/2021 | 61-0 v RennesRennes 0-1 Lille | French Ligue 1 |
| 26 | 31/1/2021 | 61-0 v DijonLille 1-0 Dijon | French Ligue 1 |
| 27 | 3/2/2021 | 63-0 v BordeauxBordeaux 0-3 Lille | French Ligue 1 |
| 28 | 7/2/2021 | 62-0 v NantesNantes 0-2 Lille | French Ligue 1 |
| 29 | 14/2/2021 | 60-0 v BrestLille 0-0 Brest | French Ligue 1 |
| 30 | 18/2/2021 | 61-2 v AjaxLille 1-2 Ajax | Europa League Round of 32 |
| 31 | 21/2/2021 | 64-1 v LorientLorient 1-4 Lille | French Ligue 1 |
| 32 | 28/2/2021 | 61-1 v StrasbourgLille 1-1 Strasbourg | French Ligue 1 |
| 33 | 3/3/2021 | 62-0 v MarseilleLille 2-0 Marseille | French Ligue 1 |
| 34 | 14/3/2021 | 60-0 v MonacoMonaco 0-0 Lille | French Ligue 1 |
| 35 | 21/3/2021 | 61-2 v NîmesLille 1-2 Nîmes | French Ligue 1 |
| 36 | 3/4/2021 | 6 1-0 v Paris St GermainParis St Germain 0-1 Lille | French Ligue 1 |
| 37 | 9/4/2021 | 6 2-0 v MetzMetz 0-2 Lille | French Ligue 1 |
| 38 | 16/4/2021 | 61-1 v MontpellierLille 1-1 Montpellier | French Ligue 1 |
| 39 | 25/4/2021 | 63-2 v LyonLyon 2-3 Lille | French Ligue 1 |
| 40 | 1/5/2021 | 62-0 v NiceLille 2-0 Nice | French Ligue 1 |
| 41 | 7/5/2021 | 6 3-0 v LensLens 0-3 Lille | French Ligue 1 |
| 42 | 16/5/2021 | 60-0 v Saint ÉtienneLille 0-0 Saint Étienne | French Ligue 1 |
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