| 1 | 10/9/2021 | 51-2 v LorientLorient 2-1 Lille | French Ligue 1 |
| 2 | 18/9/2021 | 50-1 v LensLens 1-0 Lille | French Ligue 1 |
| 3 | 22/9/2021 | 52-1 v ReimsLille 2-1 Reims | French Ligue 1 |
| 4 | 25/9/2021 | 52-1 v StrasbourgStrasbourg 1-2 Lille | French Ligue 1 |
| 5 | 29/9/2021 | 51-2 v SV Red Bull SalzburgSV Red Bull Salzburg 2-1 Lille | UEFA Champions League Group G |
| 6 | 3/10/2021 | 52-0 v MarseilleLille 2-0 Marseille | French Ligue 1 |
| 7 | 23/10/2021 | 51-1 v BrestLille 1-1 Brest | French Ligue 1 |
| 8 | 6/11/2021 | 51-1 v AngersLille 1-1 Angers | French Ligue 1 |
| 9 | 8/12/2021 | 53-1 v VfL WolfsburgVfL Wolfsburg 1-3 Lille | UEFA Champions League Group G |
| 10 | 12/12/2021 | 50-0 v LyonLille 0-0 Lyon | French Ligue 1 |
| 11 | 22/12/2021 | 53-2 v BordeauxBordeaux 2-3 Lille | French Ligue 1 |
| 12 | 16/1/2022 | 51-1 v MarseilleMarseille 1-1 Lille | French Ligue 1 |
| 13 | 19/1/2022 | 53-1 v LorientLille 3-1 Lorient | French Ligue 1 |
| 14 | 22/1/2022 | 50-2 v BrestBrest 2-0 Lille | French Ligue 1 |
| 15 | 6/2/2022 | 51-5 v Paris St GermainLille 1-5 Paris St Germain | French Ligue 1 |
| 16 | 12/2/2022 | 51-0 v MontpellierMontpellier 0-1 Lille | French Ligue 1 |
| 17 | 18/2/2022 | 50-0 v MetzLille 0-0 Metz | French Ligue 1 |
| 18 | 22/2/2022 | 50-2 v ChelseaChelsea 2-0 Lille | UEFA Champions League Round of 16 |
| 19 | 27/2/2022 | 51-0 v LyonLyon 0-1 Lille | French Ligue 1 |
| 20 | 6/3/2022 | 54-0 v ClermontLille 4-0 Clermont | French Ligue 1 |
| 21 | 11/3/2022 | 50-0 v Saint ÉtienneLille 0-0 Saint Étienne | French Ligue 1 |
| 22 | 16/3/2022 | 5 1-2 v ChelseaLille 1-2 Chelsea | UEFA Champions League Round of 16 |
| 23 | 19/3/2022 | 51-0 v NantesNantes 0-1 Lille | French Ligue 1 |
| 24 | 2/4/2022 | 50-0 v BordeauxLille 0-0 Bordeaux | French Ligue 1 |
| 25 | 10/4/2022 | 51-1 v AngersAngers 1-1 Lille | French Ligue 1 |
| 26 | 16/4/2022 | 51-2 v LensLille 1-2 Lens | French Ligue 1 |
| 27 | 20/4/2022 | 51-2 v ReimsReims 2-1 Lille | French Ligue 1 |
| 28 | 24/4/2022 | 5 1-0 v StrasbourgLille 1-0 Strasbourg | French Ligue 1 |
| 29 | 1/5/2022 | 5 0-3 v TroyesTroyes 3-0 Lille | French Ligue 1 |
| 30 | 6/5/2022 | 51-2 v MonacoLille 1-2 Monaco | French Ligue 1 |
| 31 | 14/5/2022 | 5 3-1 v NiceNice 1-3 Lille | French Ligue 1 |
| 32 | 21/5/2022 | 52-2 v RennesLille 2-2 Rennes | French Ligue 1 |
Football Web Pages