| 1 | Sat 14 Aug 2021 | 43-0 v Norwich CityNorwich City 0-3 Liverpool | Premier League |
| 2 | Sat 21 Aug 2021 | 42-0 v BurnleyLiverpool 2-0 Burnley | Premier League |
| 3 | Sat 28 Aug 2021 | 41-1 v ChelseaLiverpool 1-1 Chelsea | Premier League |
| 4 | Sun 12 Sep 2021 | 43-0 v Leeds UnitedLeeds United 0-3 Liverpool | Premier League |
| 5 | Sat 18 Sep 2021 | 43-0 v Crystal PalaceLiverpool 3-0 Crystal Palace | Premier League |
| 6 | Sat 25 Sep 2021 | 43-3 v BrentfordBrentford 3-3 Liverpool | Premier League |
| 7 | Tue 28 Sep 2021 | 45-1 v FC PortoFC Porto 1-5 Liverpool | UEFA Champions League Group B |
| 8 | Sun 3 Oct 2021 | 42-2 v Manchester CityLiverpool 2-2 Manchester City | Premier League |
| 9 | Sat 16 Oct 2021 | 45-0 v WatfordWatford 0-5 Liverpool | Premier League |
| 10 | Tue 19 Oct 2021 | 43-2 v Atlético MadridAtlético Madrid 2-3 Liverpool | UEFA Champions League Group B |
| 11 | Sun 24 Oct 2021 | 45-0 v Manchester UnitedManchester United 0-5 Liverpool | Premier League |
| 12 | Sat 30 Oct 2021 | 42-2 v Brighton & Hove AlbionLiverpool 2-2 Brighton & Hove Albion | Premier League |
| 13 | Wed 3 Nov 2021 | 42-0 v Atlético MadridLiverpool 2-0 Atlético Madrid | UEFA Champions League Group B |
| 14 | Sun 7 Nov 2021 | 42-3 v West Ham UnitedWest Ham United 3-2 Liverpool | Premier League |
| 15 | Sat 20 Nov 2021 | 44-0 v ArsenalLiverpool 4-0 Arsenal | Premier League |
| 16 | Sat 27 Nov 2021 | 44-0 v SouthamptonLiverpool 4-0 Southampton | Premier League |
| 17 | Wed 1 Dec 2021 | 4 4-1 v EvertonEverton 1-4 Liverpool | Premier League |
| 18 | Sat 4 Dec 2021 | 41-0 v Wolverhampton WanderersWolverhampton Wanderers 0-1 Liverpool | Premier League |
| 19 | Sat 11 Dec 2021 | 4 1-0 v Aston VillaLiverpool 1-0 Aston Villa | Premier League |
| 20 | Tue 28 Dec 2021 | 40-1 v Leicester CityLeicester City 1-0 Liverpool | Premier League |
| 21 | Sun 2 Jan 2022 | 42-2 v ChelseaChelsea 2-2 Liverpool | Premier League |
| 22 | Sun 9 Jan 2022 | 44-1 v Shrewsbury TownLiverpool 4-1 Shrewsbury Town | Emirates FA Cup Third Round |
| 23 | Thu 13 Jan 2022 | 40-0 v ArsenalLiverpool 0-0 Arsenal | Carabao Cup Semi Final |
| 24 | Sun 16 Jan 2022 | 43-0 v BrentfordLiverpool 3-0 Brentford | Premier League |
| 25 | Thu 20 Jan 2022 | 42-0 v ArsenalArsenal 0-2 Liverpool | Carabao Cup Semi Final |
| 26 | Sun 23 Jan 2022 | 43-1 v Crystal PalaceCrystal Palace 1-3 Liverpool | Premier League |
| 27 | Sun 6 Feb 2022 | 43-1 v Cardiff CityLiverpool 3-1 Cardiff City | Emirates FA Cup Fourth Round |
| 28 | Thu 10 Feb 2022 | 42-0 v Leicester CityLiverpool 2-0 Leicester City | Premier League |
| 29 | Sun 13 Feb 2022 | 41-0 v BurnleyBurnley 0-1 Liverpool | Premier League |
| 30 | Wed 16 Feb 2022 | 42-0 v Inter MilanInter Milan 0-2 Liverpool | UEFA Champions League Round of 16 |
| 31 | Sat 19 Feb 2022 | 43-1 v Norwich CityLiverpool 3-1 Norwich City | Premier League |
| 32 | Wed 23 Feb 2022 | 46-0 v Leeds UnitedLiverpool 6-0 Leeds United | Premier League |
| 33 | Sun 27 Feb 2022 | 40-0 v ChelseaChelsea 0-0 Liverpool | Carabao Cup Final |
| 34 | Sat 5 Mar 2022 | 41-0 v West Ham UnitedLiverpool 1-0 West Ham United | Premier League |
| 35 | Tue 8 Mar 2022 | 40-1 v Inter MilanLiverpool 0-1 Inter Milan | UEFA Champions League Round of 16 |
| 36 | Sat 12 Mar 2022 | 42-0 v Brighton & Hove AlbionBrighton & Hove Albion 0-2 Liverpool | Premier League |
| 37 | Wed 16 Mar 2022 | 42-0 v ArsenalArsenal 0-2 Liverpool | Premier League |
| 38 | Sun 20 Mar 2022 | 41-0 v Nottingham ForestNottingham Forest 0-1 Liverpool | Emirates FA Cup Sixth Round |
| 39 | Sat 2 Apr 2022 | 42-0 v WatfordLiverpool 2-0 Watford | Premier League |
| 40 | Tue 5 Apr 2022 | 43-1 v BenficaBenfica 1-3 Liverpool | UEFA Champions League Quarter Final |
| 41 | Sun 10 Apr 2022 | 4 2-2 v Manchester CityManchester City 2-2 Liverpool | Premier League |
| 42 | Sat 16 Apr 2022 | 43-2 v Manchester CityManchester City 2-3 Liverpool | Emirates FA Cup Semi Final |
| 43 | Tue 19 Apr 2022 | 44-0 v Manchester UnitedLiverpool 4-0 Manchester United | Premier League |
| 44 | Sun 24 Apr 2022 | 42-0 v EvertonLiverpool 2-0 Everton | Premier League |
| 45 | Wed 27 Apr 2022 | 4 2-0 v VillarrealLiverpool 2-0 Villarreal | UEFA Champions League Semi Final |
| 46 | Sat 30 Apr 2022 | 41-0 v Newcastle UnitedNewcastle United 0-1 Liverpool | Premier League |
| 47 | Tue 3 May 2022 | 43-2 v VillarrealVillarreal 2-3 Liverpool | UEFA Champions League Semi Final |
| 48 | Sat 7 May 2022 | 41-1 v Tottenham HotspurLiverpool 1-1 Tottenham Hotspur | Premier League |
| 49 | Tue 10 May 2022 | 42-1 v Aston VillaAston Villa 1-2 Liverpool | Premier League |
| 50 | Sat 14 May 2022 | 40-0 v ChelseaChelsea 0-0 Liverpool | Emirates FA Cup Final |
| 51 | Sat 28 May 2022 | 40-1 v Real MadridLiverpool 0-1 Real Madrid | UEFA Champions League Final |
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