| 1 | 14/8/2021 | 11-2 v Spalding UnitedSpalding United 2-1 Loughborough Dynamo | Northern Premier League - Midlands Division |
| 2 | 17/8/2021 | 13-3 v Sutton Coldfield TownLoughborough Dynamo 3-3 Sutton Coldfield Town | Northern Premier League - Midlands Division |
| 3 | 21/8/2021 | 11-3 v Cleethorpes TownCleethorpes Town 3-1 Loughborough Dynamo | Emirates FA Cup Preliminary Round |
| 4 | 24/8/2021 | 131-3 v StamfordStamford 3-1 Loughborough Dynamo | Northern Premier League - Midlands Division |
| 5 | 28/8/2021 | 1 6-2 v Sporting KhalsaLoughborough Dynamo 6-2 Sporting Khalsa | Northern Premier League - Midlands Division |
| 6 | 30/8/2021 | 1 1-0 v Shepshed DynamoShepshed Dynamo 0-1 Loughborough Dynamo | Northern Premier League - Midlands Division |
| 7 | 7/9/2021 | 16-1 v YaxleyLoughborough Dynamo 6-1 Yaxley | Northern Premier League - Midlands Division |
| 8 | 11/9/2021 | 133-1 v Soham Town RangersSoham Town Rangers 1-3 Loughborough Dynamo | Northern Premier League - Midlands Division |
| 9 | 25/9/2021 | 131-2 v Bedworth UnitedBedworth United 2-1 Loughborough Dynamo | Northern Premier League - Midlands Division |
| 10 | 28/9/2021 | 133-2 v Wisbech TownWisbech Town 2-3 Loughborough Dynamo | Northern Premier League - Midlands Division |
| 11 | 2/10/2021 | 12-0 v Daventry TownLoughborough Dynamo 2-0 Daventry Town | Northern Premier League - Midlands Division |
| 12 | 9/10/2021 | 13-6 v Sporting KhalsaLoughborough Dynamo 3-6 Sporting Khalsa | Buildbase FA Trophy Second Qualifying Round |
| 13 | 12/10/2021 | 11-1 v Halesowen TownLoughborough Dynamo 1-1 Halesowen Town | Northern Premier League - Midlands Division |
| 14 | 16/10/2021 | 11-4 v Carlton TownCarlton Town 4-1 Loughborough Dynamo | Northern Premier League - Midlands Division |
| 15 | 23/10/2021 | 11-4 v Coleshill TownLoughborough Dynamo 1-4 Coleshill Town | Northern Premier League - Midlands Division |
| 16 | 6/11/2021 | 130-3 v ChasetownChasetown 3-0 Loughborough Dynamo | Northern Premier League - Midlands Division |
| 17 | 13/11/2021 | 131-5 v Ilkeston TownLoughborough Dynamo 1-5 Ilkeston Town | Northern Premier League - Midlands Division |
| 18 | 20/11/2021 | 133-0 v Corby TownCorby Town 0-3 Loughborough Dynamo | Northern Premier League - Midlands Division |
| 19 | 27/11/2021 | 133-4 v HistonLoughborough Dynamo 3-4 Histon | Northern Premier League - Midlands Division |
| 20 | 11/12/2021 | 182-1 v Sutton Coldfield TownSutton Coldfield Town 1-2 Loughborough Dynamo | Northern Premier League - Midlands Division |
| 21 | 18/12/2021 | 133-2 v Spalding UnitedLoughborough Dynamo 3-2 Spalding United | Northern Premier League - Midlands Division |
| 22 | 27/12/2021 | 1 1-2 v Belper TownBelper Town 2-1 Loughborough Dynamo | Northern Premier League - Midlands Division |
| 23 | 3/1/2022 | 15-0 v Shepshed DynamoLoughborough Dynamo 5-0 Shepshed Dynamo | Northern Premier League - Midlands Division |
| 24 | 8/1/2022 | 12-2 v Daventry TownDaventry Town 2-2 Loughborough Dynamo | Northern Premier League - Midlands Division |
| 25 | 15/1/2022 | 11-2 v Bedworth UnitedLoughborough Dynamo 1-2 Bedworth United | Northern Premier League - Midlands Division |
| 26 | 22/1/2022 | 12-2 v Carlton TownLoughborough Dynamo 2-2 Carlton Town | Northern Premier League - Midlands Division |
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