| 1 | 7/8/2021 | 2 3-0 v Peterborough UnitedLuton Town 3-0 Peterborough United | Sky Bet Championship |
| 2 | 10/8/2021 | 22-2 v StevenageStevenage 2-2 Luton Town | Carabao Cup First Round |
| 3 | 14/8/2021 | 22-3 v West Bromwich AlbionWest Bromwich Albion 3-2 Luton Town | Sky Bet Championship |
| 4 | 17/8/2021 | 21-0 v BarnsleyBarnsley 0-1 Luton Town | Sky Bet Championship |
| 5 | 21/8/2021 | 20-5 v Birmingham CityLuton Town 0-5 Birmingham City | Sky Bet Championship |
| 6 | 28/8/2021 | 20-0 v Sheffield UnitedLuton Town 0-0 Sheffield United | Sky Bet Championship |
| 7 | 11/9/2021 | 22-2 v Blackburn RoversBlackburn Rovers 2-2 Luton Town | Sky Bet Championship |
| 8 | 15/9/2021 | 2 1-1 v Bristol CityBristol City 1-1 Luton Town | Sky Bet Championship |
| 9 | 18/9/2021 | 23-3 v Swansea CityLuton Town 3-3 Swansea City | Sky Bet Championship |
| 10 | 25/9/2021 | 21-2 v AFC BournemouthAFC Bournemouth 2-1 Luton Town | Sky Bet Championship |
| 11 | 29/9/2021 | 25-0 v Coventry CityLuton Town 5-0 Coventry City | Sky Bet Championship |
| 12 | 2/10/2021 | 20-0 v Huddersfield TownLuton Town 0-0 Huddersfield Town | Sky Bet Championship |
| 13 | 16/10/2021 | 2 2-0 v MillwallMillwall 0-2 Luton Town | Sky Bet Championship |
| 14 | 23/10/2021 | 21-0 v Hull CityLuton Town 1-0 Hull City | Sky Bet Championship |
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